Wnt signaling pathway and pluripotency (WP1129)

Canis familiaris

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.


Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz


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Canis familiaris



Pathway Ontology

Wnt signaling pathway

Cell Type Ontology

pluripotent stem cell


Label Type Compact URI Comment
APC GeneProduct ncbigene:479139
CTBP1 GeneProduct ncbigene:612240
MMP7 GeneProduct ncbigene:489432
DVL2 GeneProduct ncbigene:489464
CTNNB1 GeneProduct ncbigene:477032
WNT3A GeneProduct ncbigene:482208
JUN GeneProduct ncbigene:609429
PRKCI GeneProduct ncbigene:478686
ESRRB GeneProduct ncbigene:490798
WNT10B GeneProduct ncbigene:486561
PLAU GeneProduct ncbigene:403426
WNT2B GeneProduct ncbigene:483220
CREBBP GeneProduct ncbigene:479866
PPP2CA GeneProduct ncbigene:403608
PPP2CB GeneProduct ncbigene:482873
PRKCA GeneProduct ncbigene:490904
LEF1 GeneProduct ncbigene:478507
SOX2 GeneProduct ncbigene:488092
ZBTB33 GeneProduct ncbigene:100685062
RACGAP1 GeneProduct ncbigene:486549
MAPK10 GeneProduct ncbigene:478464
FZD2 GeneProduct ncbigene:490937
WNT2 GeneProduct ncbigene:612141
WNT9B GeneProduct ncbigene:490919
WNT5A GeneProduct ncbigene:484721
PPP2R1A GeneProduct ncbigene:484335
TCF7L1 GeneProduct ncbigene:612070
PPARD GeneProduct ncbigene:481756
EP300 GeneProduct ncbigene:100684945
PRKCQ GeneProduct ncbigene:478013
FBXW2 GeneProduct ncbigene:610990
NLK GeneProduct ncbigene:491160
WNT1 GeneProduct ncbigene:486560
PRKCB GeneProduct ncbigene:489968
PRKD1 GeneProduct ncbigene:609091
MYC GeneProduct ncbigene:403924
WNT6 GeneProduct ncbigene:488527
LOC100855811 GeneProduct ncbigene:100855811
PAFAH1B1 GeneProduct ncbigene:480656
WNT11 GeneProduct ncbigene:485183
TP53 GeneProduct ncbigene:403869
CCND1 GeneProduct ncbigene:449028
WNT3 GeneProduct ncbigene:609107
PPP2R2B GeneProduct ncbigene:478053
MAPK9 GeneProduct ncbigene:474652
POU5F1 GeneProduct ncbigene:481709
WNT7A GeneProduct ncbigene:607180
CTBP2 GeneProduct ncbigene:100684514
PPP2R1B GeneProduct ncbigene:479444
PPP2R5E GeneProduct ncbigene:480349
PRKCZ GeneProduct ncbigene:479577
LRP6 GeneProduct ncbigene:477692
FZD4 GeneProduct ncbigene:485149
DVL3 GeneProduct ncbigene:478650
FOSL1 GeneProduct ncbigene:483724
AXIN2 GeneProduct ncbigene:490903
FZD9 GeneProduct ncbigene:489809
RHOA GeneProduct ncbigene:403954
FZD6 GeneProduct ncbigene:403610
NKD1 GeneProduct ncbigene:487288
FZD7 GeneProduct ncbigene:488478
NKD2 GeneProduct ncbigene:488070
FRAT1 GeneProduct ncbigene:486819
AXIN1 GeneProduct ncbigene:490099
GSK3B GeneProduct ncbigene:478575
WNT4 GeneProduct ncbigene:612367
PPP2R2A GeneProduct ncbigene:477374
CSNK1E GeneProduct ncbigene:474510
PPP2R2C GeneProduct ncbigene:610262
FZD3 GeneProduct ncbigene:486093
CTNND1 GeneProduct ncbigene:483489
WNT10A GeneProduct ncbigene:488528
LDLR GeneProduct ncbigene:100683160
WNT11 GeneProduct ncbigene:485183 Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
PRKCE GeneProduct ncbigene:609934
LOC100855544 GeneProduct ncbigene:100855544
CCND3 GeneProduct ncbigene:608847
PPP2R3A GeneProduct ncbigene:485672
PRKCH GeneProduct ncbigene:490722
CD44 GeneProduct ncbigene:403939
WNT7B GeneProduct ncbigene:481206
WNT5B GeneProduct ncbigene:486756
FZD1 GeneProduct ncbigene:482294
PRKCD GeneProduct ncbigene:494005
PPP2R4 GeneProduct ncbigene:491303
LRP5 GeneProduct ncbigene:100306933
CCND2 GeneProduct ncbigene:611782


  1. Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Sato N, Brivanlou AH. Methods Mol Biol. 2006;331:115–28. PubMed Europe PMC Scholia
  2. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia
  3. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Yi F, Pereira L, Merrill BJ. Stem Cells. 2008 Aug;26(8):1951–60. PubMed Europe PMC Scholia
  4. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. Zhang X, Zhang J, Wang T, Esteban MA, Pei D. J Biol Chem. 2008 Dec 19;283(51):35825–33. PubMed Europe PMC Scholia