Hippo signaling regulation (WP4540)

Homo sapiens

Hippo signaling and the activation of YAP1/TAZ transcription is regulated by many other pathways (green labels) and factors. For example, the activation of SMAD and Beta catenin/TCF/LEF via TGF-beta signaling and WNT signaling pathways, respectively, enhanced the transcription of YAP1/TAZ target genes. This enhanced activity induces more aggressive phenotypes of malignant mesothelioma cells such as cell proliferation, invasion, and epithelial–mesenchymal transition (EMT). This pathway was created based on figure 2 from Sekido et al. Phosphorylation sites were added based on information from PhosphoSitePlus, www.phosphosite.org.

Authors

Alex Pico , Eric Weitz , Friederike Ehrhart , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Diseases Rare Diseases

Annotations

Disease Ontology

malignant mesothelioma

Pathway Ontology

disease pathway signaling pathway Hippo signaling pathway

Participants

Label Type Compact URI Comment
PRKAA1 GeneProduct ncbigene:5562 AMPK
PRKAA2 GeneProduct ncbigene:5563 AMPK
PRKAB1 GeneProduct ncbigene:5564 AMPK
PRKAB2 GeneProduct ncbigene:5565 AMPK
PRKAG1 GeneProduct ncbigene:5571 AMPK
PRKAG2 GeneProduct ncbigene:51422 AMPK
PRKAG3 GeneProduct ncbigene:53632 AMPK
CDH1 GeneProduct ncbigene:999 Cadherin
CDH10 GeneProduct ncbigene:1008 Cadherin
CDH11 GeneProduct ncbigene:1009 Cadherin
CDH12 GeneProduct ncbigene:1010 Cadherin
CDH13 GeneProduct ncbigene:1012 Cadherin
CDH15 GeneProduct ncbigene:1013 Cadherin
CDH16 GeneProduct ncbigene:1014 Cadherin
CDH17 GeneProduct ncbigene:1015 Cadherin
CDH18 GeneProduct ncbigene:1016 Cadherin
CDH19 GeneProduct ncbigene:28513 Cadherin
CDH2 GeneProduct ncbigene:1000 Cadherin
CDH20 GeneProduct ncbigene:28316 Cadherin
CDH22 GeneProduct ncbigene:64405 Cadherin
CDH24 GeneProduct ncbigene:64403 Cadherin
CDH3 GeneProduct ncbigene:1001 Cadherin
CDH4 GeneProduct ncbigene:1002 Cadherin
CDH5 GeneProduct ncbigene:1003 Cadherin
CDH6 GeneProduct ncbigene:1004 Cadherin
CDH7 GeneProduct ncbigene:1005 Cadherin
CDH8 GeneProduct ncbigene:1006 Cadherin
CDH9 GeneProduct ncbigene:1007 Cadherin
GNA11 GeneProduct ncbigene:2767 Ga/1
GNAI2 GeneProduct ncbigene:2771 Ga/1
GNAI3 GeneProduct ncbigene:2773 Ga/1
GNAL GeneProduct ncbigene:2774 Ga/1
GNAQ GeneProduct ncbigene:2776 Ga/1
GNAS GeneProduct ncbigene:2778 Ga/1
PRKACA GeneProduct ncbigene:5566 PKA
PRKACB GeneProduct ncbigene:5567 PKA
PRKACG GeneProduct ncbigene:5568 PKA
PRKAR1A GeneProduct ncbigene:5573 PKA
PRKAR1B GeneProduct ncbigene:5575 PKA
PRKAR2A GeneProduct ncbigene:5576 PKA
PRKAR2B GeneProduct ncbigene:5577 PKA
PRKCA GeneProduct ncbigene:5578 PKC
PRKCB GeneProduct ncbigene:5579 PKC
PRKCD GeneProduct ncbigene:5580 PKC
PRKCE GeneProduct ncbigene:5581 PKC
PRKCG GeneProduct ncbigene:5582 PKC
PRKCH GeneProduct ncbigene:5583 PKC
PRKCI GeneProduct ncbigene:5584 PKC
PRKCQ GeneProduct ncbigene:5588 PKC
PRKCZ GeneProduct ncbigene:5590 PKC
PRKD3 GeneProduct ncbigene:23683 PKC
PLCB1 GeneProduct ncbigene:23236 PLCB
PLCB2 GeneProduct ncbigene:5330 PLCB
PLCB3 GeneProduct ncbigene:5331 PLCB
PLCB4 GeneProduct ncbigene:5332 PLCB
SMAD3 GeneProduct ncbigene:4088 SMAD
CDC42 GeneProduct ncbigene:998
SMAD2 GeneProduct ncbigene:4087 SMAD
MTOR GeneProduct ncbigene:2475 mTOR
LATS2 GeneProduct ncbigene:26524 LATS1/2
STK3 GeneProduct ncbigene:6788 MST1/2
LATS1 GeneProduct ncbigene:9113 LATS1/2
NF2 GeneProduct ncbigene:4771 Nf2
STK4 GeneProduct ncbigene:4485 MST1/2
TEAD1 GeneProduct ensembl:ENSG00000187079
TEAD2 GeneProduct ensembl:ENSG00000074219
TEAD3 GeneProduct ensembl:ENSG00000007866
TEAD4 GeneProduct ensembl:ENSG00000197905
FGFR2 GeneProduct ensembl:ENSG00000066468 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14183
KDR GeneProduct ensembl:ENSG00000128052 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16542
INSR GeneProduct ensembl:ENSG00000171105 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
FGFR3 GeneProduct ensembl:ENSG00000068078 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14184
IGF1R GeneProduct ensembl:ENSG00000140443 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16001
KIT GeneProduct ensembl:ENSG00000157404 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16590
FGFR1 GeneProduct ensembl:ENSG00000077782 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14182
EPHA2 GeneProduct ensembl:ENSG00000142627 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13836
EGFR GeneProduct ensembl:ENSG00000146648 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13649
CSF1R GeneProduct ensembl:ENSG00000182578 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12978
FGFR4 GeneProduct ensembl:ENSG00000160867 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14186
FLT1 GeneProduct ensembl:ENSG00000102755 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14254
FLT4 GeneProduct ensembl:ENSG00000037280 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
NGFR GeneProduct ensembl:ENSG00000064300 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18053
MET GeneProduct ensembl:ENSG00000105976 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17295
PDGFRA GeneProduct ensembl:ENSG00000134853 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18595
PDGFRB GeneProduct ensembl:ENSG00000113721 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18596
TEK GeneProduct ensembl:ENSG00000120156 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
FLT3 GeneProduct ensembl:ENSG00000122025 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14257
NTRK1 GeneProduct ensembl:ENSG00000198400 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
NTRK2 GeneProduct ensembl:ENSG00000148053 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
RHOA GeneProduct ncbigene:387
RAC1 GeneProduct ncbigene:5879
LEF1 GeneProduct ensembl:ENSG00000138795
TCF7L1 GeneProduct ensembl:ENSG00000152284
TCF7L2 GeneProduct ensembl:ENSG00000148737
TCF7 GeneProduct ensembl:ENSG00000081059
CTNNB1 GeneProduct ncbigene:1499
WWTR1 GeneProduct ncbigene:25937
YAP1 GeneProduct ncbigene:10413

References

  1. Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Sekido Y. Cancers (Basel). 2018 Mar 22;10(4):90. PubMed Europe PMC Scholia