Kit receptor signaling pathway (WP774)

Gallus gallus

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Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_6

Authors

Alex Pico , Daniela Digles , and Eric Weitz

Activity

last edited

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Organisms

Gallus gallus

Communities

Annotations

Pathway Ontology

Stem Cell Factor signaling pathway

Participants

Label Type Compact URI Comment
PIK3R1 GeneProduct ncbigene:427171
PIK3R2 GeneProduct ncbigene:771142
SHC1 GeneProduct ncbigene:395934
CSF2RB GeneProduct ncbigene:771315
GRB2 GeneProduct ncbigene:386572
SOCS6 GeneProduct ncbigene:421020
SOCS4 GeneProduct ncbigene:423557
SOCS5 GeneProduct ncbigene:428570
CISH GeneProduct ncbigene:395335
CLTC GeneProduct ncbigene:395272
CRK GeneProduct ncbigene:417553
SRC GeneProduct ncbigene:396442
PLCE1 GeneProduct ncbigene:428962
JAK2 GeneProduct ncbigene:374199
GRAP GeneProduct ncbigene:416523
PTPRU GeneProduct ncbigene:395153
STAP1 GeneProduct ncbigene:428761
RCJMB04_5a10 GeneProduct ncbigene:417430
RCJMB04_17i9 GeneProduct ncbigene:424044
STAT5B GeneProduct ncbigene:395556
PIK3CG GeneProduct ncbigene:417706
SH2B2 GeneProduct ncbigene:771172
GRB10 GeneProduct ncbigene:420948
AKT1 GeneProduct ncbigene:395928
TEC GeneProduct ncbigene:396407
LYN GeneProduct ncbigene:421127
DOK1 GeneProduct ncbigene:430423
PTPN6 GeneProduct ncbigene:427947
PTPN11 GeneProduct ncbigene:395815
RPS6KA1 GeneProduct ncbigene:386579
MITF GeneProduct ncbigene:395886
MAPK1 GeneProduct ncbigene:373953
ABL1 GeneProduct ncbigene:417181
INPP5D GeneProduct ncbigene:424745
HCK GeneProduct ncbigene:419280
YES1 GeneProduct ncbigene:396238
RASA1 GeneProduct ncbigene:427327
FES GeneProduct ncbigene:429374
CRKL GeneProduct ncbigene:416939
CBL GeneProduct ncbigene:374038
SOCS1 GeneProduct ncbigene:416630
VAV2 GeneProduct ncbigene:373938
MATK GeneProduct ncbigene:769076
SOS1 GeneProduct ncbigene:425964
EP300 GeneProduct ncbigene:418000
FYN GeneProduct ncbigene:396294
PRKCB GeneProduct ncbigene:416567
HRAS GeneProduct ncbigene:396229
RAF1 GeneProduct ncbigene:396245
SPRED2 GeneProduct ncbigene:421271
SPRED1 GeneProduct ncbigene:423292
SH3KBP1 GeneProduct ncbigene:418608
CBLB GeneProduct ncbigene:418406
BTK GeneProduct ncbigene:374075
KIT GeneProduct ncbigene:378783
KITLG GeneProduct ncbigene:396028
KIT GeneProduct ncbigene:378783
KITLG GeneProduct ncbigene:396028
MAP2K1 GeneProduct ncbigene:415549
STAT3 GeneProduct ncbigene:420027
DOK1 GeneProduct ncbigene:430423

References