IL-17 signaling pathway (WP3176)
Bos taurus
Interleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as proinflammatory cytokines that responds to the invasion of the immune system by extracellular pathogens. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1.
Authors
Martina Summer-Kutmon , Mick Eikelhof , Kristina Hanspers , and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
cytokine mediated signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| TRAF6 | GeneProduct | ensembl:ENSBTAG00000036009 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189 |
| IL17RD | GeneProduct | ensembl:ENSBTAG00000010999 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54756 |
| IKBKG | GeneProduct | ensembl:ENSBTAG00000006268 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517 |
| MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | p38HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 |
| RELA | GeneProduct | ensembl:ENSBTAG00000013895 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970 |
| GSK3B | GeneProduct | ensembl:ENSBTAG00000048057 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932 |
| SP1 | GeneProduct | ensembl:ENSBTAG00000003021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667 |
| NFKB1 | GeneProduct | ensembl:ENSBTAG00000020270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790 |
| IL17RE | GeneProduct | ensembl:ENSBTAG00000010833 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:132014 |
| IL17 | GeneProduct | ensembl:ENSBTAG00000002150 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3605 |
| AKT1 | GeneProduct | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| IL17F | GeneProduct | ensembl:ENSBTAG00000016835 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112744 |
| TRAF3IP2 | GeneProduct | ensembl:ENSBTAG00000008600 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10758 |
| JAK2 | GeneProduct | ensembl:ENSBTAG00000012047 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717 |
| IKBKB | GeneProduct | ensembl:ENSBTAG00000007599 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551 |
| IL17D | GeneProduct | ensembl:ENSBTAG00000025402 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53342 |
| STAT3 | GeneProduct | ensembl:ENSBTAG00000021523 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774 |
| NFKBIB | GeneProduct | ensembl:ENSBTAG00000001778 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4793 |
| IL17C | GeneProduct | ensembl:ENSBTAG00000047128 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27189 |
| IL25 | GeneProduct | ensembl:ENSBTAG00000009701 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64806 |
| IL17RC | GeneProduct | ensembl:ENSBTAG00000033669 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84818 |
| MAP3K7 | GeneProduct | ensembl:ENSBTAG00000002625 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885 |
| IL17RA | GeneProduct | ensembl:ENSBTAG00000011067 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23765 |
| IL17RB | GeneProduct | ensembl:ENSBTAG00000011178 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55540 |
| IL17B | GeneProduct | ensembl:ENSBTAG00000010578 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27190 |
| MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 |
| JAK1 | GeneProduct | ensembl:ENSBTAG00000003147 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716 |
| TRAF3 | GeneProduct | ensembl:ENSBTAG00000013475 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7187 |
| TRAF3IP2 | GeneProduct | ensembl:ENSBTAG00000008600 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10758 |
| MAP3K7 | GeneProduct | ensembl:ENSBTAG00000002625 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885 |
| TRAF6 | GeneProduct | ensembl:ENSBTAG00000036009 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7189 |
| TRAF3IP2 | GeneProduct | ensembl:ENSBTAG00000008600 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10758 |
| NFKB1 | GeneProduct | ensembl:ENSBTAG00000020270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790 |
| RELA | GeneProduct | ensembl:ENSBTAG00000013895 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970 |
| MAPK3 | GeneProduct | ensembl:ENSBTAG00000016156 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595 |