Nuclear receptors (WP831)

Gallus gallus

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a ligand a molecule which affects the receptor's behavior is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. As discussed in more detail below, nuclear receptors may be classified either according to mechanism or homology. Source: Wikipedia ([[wikipedia:Nuclear_receptor]])


Alex Pico , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


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Gallus gallus



Pathway Ontology

transcription factor mediated signaling pathway


Label Type Compact Identifier Comment
THRA GeneProduct ncbigene:396251
THRB GeneProduct ncbigene:396431
THRB GeneProduct ncbigene:396431
RARA GeneProduct ncbigene:395213
RARB GeneProduct ncbigene:396266
PPARA GeneProduct ncbigene:374120
PPARD GeneProduct ncbigene:395479
PPARG GeneProduct ncbigene:373928
PPARG GeneProduct ncbigene:373928
NR1D2 GeneProduct ncbigene:396125
NR0B1 GeneProduct ncbigene:395285
ROR1 GeneProduct ncbigene:395179
RORA GeneProduct ncbigene:415377
NR1H3 GeneProduct ncbigene:395221
VDR GeneProduct ncbigene:395988
HNF4A GeneProduct ncbigene:419198
RXRA GeneProduct ncbigene:417143
RXRG GeneProduct ncbigene:396231
NR2C2 GeneProduct ncbigene:395253
NR2F2 GeneProduct ncbigene:386585
NR2F6 GeneProduct ncbigene:474359
NR2E1 GeneProduct ncbigene:396082
ESR1 GeneProduct ncbigene:396099
ESR2 GeneProduct ncbigene:395575
ESRRB GeneProduct ncbigene:771938
NR3C1 GeneProduct ncbigene:416343
PGR GeneProduct ncbigene:396198
AR GeneProduct ncbigene:422165
NR4A2 GeneProduct ncbigene:424320
NR5A1 GeneProduct ncbigene:395960
NR5A2 GeneProduct ncbigene:395961
NR1I3 GeneProduct ncbigene:395439


  1. Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease. Nagy L, Schüle R, Gronemeyer H. EMBO Rep. 2006 Jun;7(6):579–84. PubMed Europe PMC Scholia