PGK1, PKM2, KHKC/KHKA acting as protein kinases (WP5433)

Homo sapiens

Authors

Marcell Levay and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

glycolysis pathway kinase mediated signaling pathway

Cell Type Ontology

eukaryotic cell

References

1. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Gao X, Wang H, Yang JJ, Liu X, Liu ZR. Mol Cell. 2012 Mar 9;45(5):598–609. PubMed Europe PMC Scholia
2. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, et al. Cell. 2012 Aug 17;150(4):685–96. PubMed Europe PMC Scholia
3. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, et al. Mol Cell. 2014 Jan 9;53(1):75–87. PubMed Europe PMC Scholia
4. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, et al. Nat Commun. 2014 Nov 21;5:5566. PubMed Europe PMC Scholia
5. Pyruvate kinase M2 at a glance. Yang W, Lu Z. J Cell Sci. 2015 May 1;128(9):1655–60. PubMed Europe PMC Scholia
6. Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1. He CL, Bian YY, Xue Y, Liu ZX, Zhou KQ, Yao CF, et al. Sci Rep. 2016 Feb 15;6:21524. PubMed Europe PMC Scholia
7. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke DH, Zheng Y, et al. Mol Cell. 2016 Mar 3;61(5):705–19. PubMed Europe PMC Scholia
8. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, et al. Nat Cell Biol. 2016 May;18(5):561–71. PubMed Europe PMC Scholia
9. PGK1 is a new member of the protein kinome. Li X, Zheng Y, Lu Z. Cell Cycle. 2016 Jul 17;15(14):1803–4. PubMed Europe PMC Scholia
10. Fructokinase A acts as a protein kinase to promote nucleotide synthesis. Li X, Qian X, Lu Z. Cell Cycle. 2016 Oct 17;15(20):2689–90. PubMed Europe PMC Scholia
11. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, et al. Cell Res. 2017 Mar;27(3):329–51. PubMed Europe PMC Scholia
12. Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23. Wei Y, Wang D, Jin F, Bian Z, Li L, Liang H, et al. Nat Commun. 2017 Jan 9;8:14041. PubMed Europe PMC Scholia
13. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, et al. Mol Cell. 2017 Mar 2;65(5):917-931.e6. PubMed Europe PMC Scholia
14. Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells. Xia L, Qin K, Wang XR, Wang XL, Zhou AW, Chen GQ, et al. Oncotarget. 2017 Nov 17;8(65):109120–34. PubMed Europe PMC Scholia
15. Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein. Cheng TY, Yang YC, Wang HP, Tien YW, Shun CT, Huang HY, et al. Oncogene. 2018 Mar;37(13):1730–42. PubMed Europe PMC Scholia