Regulation of actin cytoskeleton (WP523)

Mus musculus

A cytoskeleton is a complex, dynamic network of interlinking protein filaments that extends from the cell nucleus to the cell membrane. Actin filaments, composed of the abundant actin protein, are a main component of the cytoskeleton, playing a key role muscle contraction.


Nathan Salomonis , Thomas Kelder , Daniela Digles , Kristina Hanspers , Lauren J. Dupuis , Eric Weitz , and Alex Pico


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Mus musculus



Pathway Ontology

cell adhesion signaling pathway


Label Type Compact URI Comment
PIP2 Metabolite kegg.compound:C04637
Bradykinin Metabolite hmdb:HMDB0004246
Acetylcholine Metabolite hmdb:HMDB0000895
LPS Metabolite kegg.compound:C00338
PIP3 Metabolite kegg.compound:C05981
PIP2 Metabolite kegg.compound:C04637
Diap3 GeneProduct ncbigene:56419
Pip4k2b GeneProduct ncbigene:108083
Mapk1 GeneProduct ncbigene:26413
Chrm3 GeneProduct ncbigene:12671
Pip5k1b GeneProduct ncbigene:18719
Gsn GeneProduct ncbigene:227753
Ssh1 GeneProduct ncbigene:231637
Pak1 GeneProduct ncbigene:18479
Pfn1 GeneProduct ncbigene:18643
Pik3c3 GeneProduct ncbigene:225326
Fgf5 GeneProduct ncbigene:14176
Pdgfa GeneProduct ncbigene:18590
Fgd1 GeneProduct ncbigene:14163
Pik3r5 GeneProduct ncbigene:320207
Sos2 GeneProduct ncbigene:20663
Baiap2 GeneProduct ncbigene:108100
Iqgap1 GeneProduct ncbigene:29875
Vcl GeneProduct ncbigene:22330
Fgf10 GeneProduct ncbigene:14165
Arhgef1 GeneProduct ncbigene:16801
Arhgef7 GeneProduct ncbigene:54126
Gna13 GeneProduct ncbigene:14674
Rdx GeneProduct ncbigene:19684
Myh10 GeneProduct ncbigene:77579
Abi2 GeneProduct ncbigene:329165
Pfn1 GeneProduct ncbigene:18643
Chrm2 GeneProduct ncbigene:243764
Chrm1 GeneProduct ncbigene:12669
Pik3c2b GeneProduct ncbigene:240752
Fgf9 GeneProduct ncbigene:14180
Egfr GeneProduct ncbigene:13649
Vcl GeneProduct ncbigene:22330
Enah GeneProduct ncbigene:13800
Ssh2 GeneProduct ncbigene:237860
Grlf1 GeneProduct ncbigene:232906
Rac3 GeneProduct ncbigene:170758
Wasf2 GeneProduct ncbigene:242687
Pak7 GeneProduct ncbigene:241656
Pip5kl1 GeneProduct ncbigene:227733
Mras GeneProduct ncbigene:17532
Map2k1 GeneProduct ncbigene:26395
Limk1 GeneProduct ncbigene:16885
Bdkrb1 GeneProduct ncbigene:12061
Fgf7 GeneProduct ncbigene:14178
Vil1 GeneProduct ncbigene:22349
Gna12 GeneProduct ncbigene:14673
Nckap1 GeneProduct ncbigene:50884
Fgf14 GeneProduct ncbigene:14169
Actb GeneProduct ncbigene:11461
Pik3r2 GeneProduct ncbigene:18709
Pak2 GeneProduct ncbigene:224105
Fgfr4 GeneProduct ncbigene:14186
Fgf3 GeneProduct ncbigene:14174
Chrm5 GeneProduct ncbigene:213788
Fgf12 GeneProduct ncbigene:14167
Cdc42 GeneProduct ncbigene:12540
Tmsb4x GeneProduct ncbigene:19241
Pik3c2g GeneProduct ncbigene:18705
Egf GeneProduct ncbigene:13645
Arhgef4 GeneProduct ncbigene:226970
Bcar1 GeneProduct ncbigene:12927
Mylk GeneProduct ncbigene:107589
Ssh3 GeneProduct ncbigene:245857
Actb GeneProduct ncbigene:11461
Fgf4 GeneProduct ncbigene:14175
Pik3r1 GeneProduct ncbigene:18708
Pak3 GeneProduct ncbigene:18481
Dock1 GeneProduct ncbigene:330662
Chrm4 GeneProduct ncbigene:12672
Cfl2 GeneProduct ncbigene:12632
Cd14 GeneProduct ncbigene:12475
Pdgfrb GeneProduct ncbigene:18596
Arpc5 GeneProduct ncbigene:67771
Pik3ca GeneProduct ncbigene:18706
Ptk2 GeneProduct ncbigene:14083
Fgf20 GeneProduct ncbigene:80857
Fgf17 GeneProduct ncbigene:14171
Arpc5 GeneProduct ncbigene:67771
Rhoa GeneProduct ncbigene:11848
Actb GeneProduct ncbigene:11461
Slc9a1 GeneProduct ncbigene:20544
Fgfr3 GeneProduct ncbigene:14184
Pik3c2a GeneProduct ncbigene:18704
Fgf23 GeneProduct ncbigene:64654
Pik3cb GeneProduct ncbigene:74769
Bdkrb2 GeneProduct ncbigene:12062
Rock2 GeneProduct ncbigene:19878
Fgf15 GeneProduct ncbigene:14170
Fgf18 GeneProduct ncbigene:14172
Pip4k2a GeneProduct ncbigene:18718
Fgf21 GeneProduct ncbigene:56636
Nras GeneProduct ncbigene:18176
Fgf2 GeneProduct ncbigene:14173
Pik3r3 GeneProduct ncbigene:18710
Ezr GeneProduct ncbigene:22350
Rock1 GeneProduct ncbigene:19877
Actg1 GeneProduct ncbigene:11465
Fgf22 GeneProduct ncbigene:67112
Fn1 GeneProduct ncbigene:14268
Fgf16 GeneProduct ncbigene:80903
Pik3cg GeneProduct ncbigene:30955
Arhgef6 GeneProduct ncbigene:73341
Myl1 GeneProduct ncbigene:17901
Rac1 GeneProduct ncbigene:19353
Braf GeneProduct ncbigene:109880
Ppp1r12a GeneProduct ncbigene:17931
Was GeneProduct ncbigene:22376
Rras2 GeneProduct ncbigene:66922
Pik3r4 GeneProduct ncbigene:75669
Baiap2 GeneProduct ncbigene:108100
Rras GeneProduct ncbigene:20130
Actg1 GeneProduct ncbigene:11465
Apc GeneProduct ncbigene:11789
Rassf7 GeneProduct ncbigene:66985
Pdgfra GeneProduct ncbigene:18595
Kras GeneProduct ncbigene:16653
Fgf13 GeneProduct ncbigene:14168
Pip5k1a GeneProduct ncbigene:18720
Wasf1 GeneProduct ncbigene:83767
Pak4 GeneProduct ncbigene:70584
Actn1 GeneProduct ncbigene:109711
Gng12 GeneProduct ncbigene:14701
Diap1 GeneProduct ncbigene:13367
Pip5k1c GeneProduct ncbigene:18717
Sos1 GeneProduct ncbigene:20662
Msn GeneProduct ncbigene:17698
Crk GeneProduct ncbigene:12928
Ins2 GeneProduct ncbigene:16334
Itga1 GeneProduct ncbigene:109700
Raf1 GeneProduct ncbigene:110157
Csk GeneProduct ncbigene:12988
Pip4k2a GeneProduct ncbigene:18718
Pip4k2c GeneProduct ncbigene:117150
Mapk3 GeneProduct ncbigene:26417
Pdgfb GeneProduct ncbigene:18591
Cyfip2 GeneProduct ncbigene:76884
Myl3 GeneProduct ncbigene:17897
Actg1 GeneProduct ncbigene:11465
Map2k2 GeneProduct ncbigene:26396
Arhgef6 GeneProduct ncbigene:73341
Pxn GeneProduct ncbigene:19303
Rac2 GeneProduct ncbigene:19354
Ins1 GeneProduct ncbigene:16333
Fgfr2 GeneProduct ncbigene:14183
Pik3cd GeneProduct ncbigene:18707
Mapk6 GeneProduct ncbigene:50772
Pak6 GeneProduct ncbigene:214230
Apc2 GeneProduct ncbigene:23805
Git1 GeneProduct ncbigene:216963
Cfl1 GeneProduct ncbigene:12631
Mos GeneProduct ncbigene:17451
Fgf6 GeneProduct ncbigene:14177
Fgf1 GeneProduct ncbigene:14164
F2 GeneProduct ncbigene:14061
F2r GeneProduct ncbigene:14062
Fgfr1 GeneProduct ncbigene:14182
Fgf11 GeneProduct ncbigene:14166
Fgf8 GeneProduct ncbigene:14179
Vav1 GeneProduct ncbigene:22324
Mapk4 GeneProduct ncbigene:225724
Brk1 Protein uniprot:Q91VR8