Genetic interactions between sugar and hormone signaling (WP3661)

Arabidopsis thaliana

The pathway initiated by GLC activates the AtHXK1/GIN2 complex and can also interact with a AtHXK1 independent pathway. The AtHXK1/GIN2 complex functions to activate ABA2/ABA3 protein complex, also regulated by stress, to catalyze production of abscisic acid, a compound that both directly and indirectly promotes seed development, but inhibits germination, cotyledon greening, expansion, shoot development, and flowering (plant development). The AtHXK1/GIN2 complex also activates auxin to inhibit the plant development processes and represses cytokinin as well as the ethylene signaling pathway to stop promotion of plant growth. This pathway is based on figure 5 from Rolland et al and figure 3 from Ramon et al.


AAR&Co , Kristina Hanspers , Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen


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Arabidopsis thaliana



Pathway Ontology

glucose homeostasis pathway


Label Type Compact URI Comment
Auxin Metabolite hmdb:HMDB0038483 Auxin Not Specified
Abscisic acid Metabolite hmdb:HMDB0036093
Ethylene Metabolite hmdb:HMDB0029594
Glucose Metabolite hmdb:HMDB0000122
Cytokinin Metabolite hmdb:HMDB0039238 Cytokinin Not Specified
EIN5/7 GeneProduct uniprot:Q9FQ04
MPK3 GeneProduct uniprot:Q39023
ABA2 GeneProduct ensembl:AT1G52340
GIN2 / HXK1 GeneProduct uniprot:Q42525
ABI3 GeneProduct ensembl:AT3G24650
ABI2 GeneProduct ensembl:AT5G57050
MKK9 GeneProduct uniprot:Q9FX43
EIN2 GeneProduct ensembl:AT5G03280
GIN6 / ABI4 GeneProduct ensembl:AT2G40220
ETR1 GeneProduct ensembl:AT1G66340
ABI1 GeneProduct ensembl:AT4G26080
MPK6 GeneProduct uniprot:Q39026
ABI5 GeneProduct ensembl:AT2G36270
EIN3 GeneProduct ensembl:AT3G20770
GIN4 / CTR1 GeneProduct ensembl:AT5G03730
ABA3 GeneProduct ensembl:AT1G16540
ABI4 GeneProduct ensembl:AT2G40220
ABI5 GeneProduct ensembl:AT2G36270
EIN2 GeneProduct ensembl:AT5G03280
EIN3 GeneProduct ensembl:AT3G20770
ETO1 GeneProduct ensembl:AT3G51770
ABF3 GeneProduct ensembl:AT4G34000
ABF4 GeneProduct ensembl:AT3G19290
ABA1 GeneProduct ncbigene:836838
AAO3 GeneProduct ensembl:AT2G27150
ABI3 GeneProduct ensembl:AT3G24650
ABI4 GeneProduct ensembl:AT2G40220
ABI5 GeneProduct ensembl:AT2G36270
ABF2 GeneProduct ensembl:AT1G45249
ABF2 GeneProduct ncbigene:820002


  1. Sugar sensing and signaling in plants. Rolland F, Moore B, Sheen J. Plant Cell. 2002;14 Suppl(Suppl):S185-205. PubMed Europe PMC Scholia
  2. Sugar sensing and signaling. Ramon M, Rolland F, Sheen J. Arabidopsis Book. 2008;6:e0117. PubMed Europe PMC Scholia