G protein signaling pathways (WP232)

Mus musculus

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]]


Nathan Salomonis , Bruce Conklin , Charles Redfern , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz


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Mus musculus



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
IP3 Metabolite hmdb:HMDB0001143
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite kegg.compound:C00165
cAMP Metabolite hmdb:HMDB0000058
Prkar2b GeneProduct ncbigene:19088
Gng10 GeneProduct ncbigene:14700
Pde7b GeneProduct ncbigene:29863
Adcy3 GeneProduct ncbigene:104111
Adcy5 GeneProduct ncbigene:224129
Gng12 GeneProduct ncbigene:14701
Gng11 GeneProduct ncbigene:66066
Akap8 GeneProduct ncbigene:56399
Ppp3cc GeneProduct ncbigene:19057
Akap1 GeneProduct ncbigene:11640
Prkar1b GeneProduct ncbigene:19085
Gnas GeneProduct ncbigene:14683
Prkcd GeneProduct ncbigene:18753
Gnb3 GeneProduct ncbigene:14695
Pde4a GeneProduct ncbigene:18577
Pde1b GeneProduct ncbigene:18574
Gnaq GeneProduct ncbigene:14682
Gnao1 GeneProduct ncbigene:14681
Pde4d GeneProduct ncbigene:238871
Prkcb GeneProduct ncbigene:18751
Rras GeneProduct ncbigene:20130
Gna14 GeneProduct ncbigene:14675
Akap5 GeneProduct ncbigene:238276
Gnaz GeneProduct ncbigene:14687
Adcy4 GeneProduct ncbigene:104110
Pde8b GeneProduct ncbigene:218461
Nras GeneProduct ncbigene:18176
Gng13 GeneProduct ncbigene:64337
Gngt1 GeneProduct ncbigene:14699
Gnb2 GeneProduct ncbigene:14693
Prkar1a GeneProduct ncbigene:19084
Gna11 GeneProduct ncbigene:14672
Prkch GeneProduct ncbigene:18755
Ppp3ca GeneProduct ncbigene:19055
Gnai1 GeneProduct ncbigene:14677
Calm1 GeneProduct ncbigene:12313
Prkacb GeneProduct ncbigene:18749
Prkar2a GeneProduct ncbigene:19087
Gnb5 GeneProduct ncbigene:14697
Kcnj3 GeneProduct ncbigene:16519
Plcb3 GeneProduct ncbigene:18797
Akap7 GeneProduct ncbigene:432442
Gna13 GeneProduct ncbigene:14674
Adcy6 GeneProduct ncbigene:11512
Akap3 GeneProduct ncbigene:11642
Pde1a GeneProduct ncbigene:18573
Pde1c GeneProduct ncbigene:18575
Adcy2 GeneProduct ncbigene:210044
Gnao1 GeneProduct ncbigene:14681
Gnal GeneProduct ncbigene:14680
Prkd1 GeneProduct ncbigene:18760
Prkd3 GeneProduct ncbigene:75292
Adcy9 GeneProduct ncbigene:11515
Akap6 GeneProduct ncbigene:238161
Adcy1 GeneProduct ncbigene:432530
Ppp3cc GeneProduct ncbigene:19057
Akap13 GeneProduct ncbigene:75547
Gna15 GeneProduct ncbigene:14676
Pde8a GeneProduct ncbigene:18584
Akap12 GeneProduct ncbigene:83397
Rhoa GeneProduct ncbigene:11848
Akap4 GeneProduct ncbigene:11643
Gnai3 GeneProduct ncbigene:14679
Akap11 GeneProduct ncbigene:219181
Gngt2 GeneProduct ncbigene:14710
Prkcq GeneProduct ncbigene:18761
Akap2 GeneProduct ncbigene:11641
Pde4c GeneProduct ncbigene:110385
Gng8 GeneProduct ncbigene:14709
Prkce GeneProduct ncbigene:18754
Gng7 GeneProduct ncbigene:14708
Prkcc GeneProduct ncbigene:18752
Gnb1 GeneProduct ncbigene:14688
Prkca GeneProduct ncbigene:18750
Prkci GeneProduct ncbigene:18759
Gng5 GeneProduct ncbigene:14707
Gng3 GeneProduct ncbigene:14704
Hras1 GeneProduct ncbigene:15461
Prkcz GeneProduct ncbigene:18762
Arhgef1 GeneProduct ncbigene:16801
Akap10 GeneProduct ncbigene:56697
Gnai1 GeneProduct ncbigene:14677
Adcy8 GeneProduct ncbigene:11514
Adcy7 GeneProduct ncbigene:11513
Prkaca GeneProduct ncbigene:18747
Pde4b GeneProduct ncbigene:18578
Kras GeneProduct ncbigene:16653
Pde7a GeneProduct ncbigene:18583
Akap9 GeneProduct ncbigene:100986
Gng4 GeneProduct ncbigene:14706
Gna12 GeneProduct ncbigene:14673
Itpr1 GeneProduct ncbigene:16438
Slc9a1 GeneProduct ncbigene:20544
Gnai2 GeneProduct ncbigene:14678


  1. G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
  2. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia