G protein signaling (WP35)

Homo sapiens

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes. Source: [[wikipedia:G_protein|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP35 CPTAC Assay Portal]


Nathan Salomonis , Alex Pico , Bruce Conklin , Charles Redfern , Thomas Kelder , Samuel Sklar , Zahra Roudbari , Martina Summer-Kutmon , Kristina Hanspers , and Eric Weitz


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Homo sapiens



Pathway Ontology

G protein mediated signaling pathway G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway via Galphas family


Label Type Compact URI Comment
IP3 Metabolite hmdb:HMDB0001143
Ca2+ Metabolite hmdb:HMDB0000464
DAG Metabolite kegg.compound:C00165
cAMP Metabolite hmdb:HMDB0000058
PRKAR2B GeneProduct ncbigene:5577
GNG10 GeneProduct ncbigene:2790
PDE7B GeneProduct ncbigene:27115
ADCY3 GeneProduct ncbigene:109
ADCY5 GeneProduct ncbigene:111
GNG12 GeneProduct ncbigene:55970
GNG11 GeneProduct ncbigene:2791
AKAP8 GeneProduct ncbigene:10270
PPP3CC GeneProduct ncbigene:5533
AKAP1 GeneProduct ncbigene:8165
PRKAR1B GeneProduct ncbigene:5575
GNAS GeneProduct ncbigene:2778
PRKCD GeneProduct ncbigene:5580
GNB3 GeneProduct ncbigene:2784
PDE4A GeneProduct ncbigene:5141
PDE1B GeneProduct ncbigene:5153
GNAQ GeneProduct ncbigene:2776
GNAO1 GeneProduct ncbigene:2775
PDE4D GeneProduct ncbigene:5144
PRKCB1 GeneProduct ncbigene:5579
RRAS GeneProduct ncbigene:6237
GNA14 GeneProduct ncbigene:9630
AKAP5 GeneProduct ncbigene:9495
GNAZ GeneProduct ncbigene:2781
ADCY4 GeneProduct ncbigene:196883
PDE8B GeneProduct ncbigene:8622
NRAS GeneProduct ncbigene:4893
GNG13 GeneProduct ncbigene:51764
GNGT1 GeneProduct ncbigene:2792
GNB2 GeneProduct ncbigene:2783
PRKAR1A GeneProduct ncbigene:5573
GNA11 GeneProduct ncbigene:2767
PRKCH GeneProduct ncbigene:5583
PPP3CA GeneProduct ncbigene:5530
GNAI1 GeneProduct ncbigene:2770
CALM1 GeneProduct ncbigene:801
PRKACB GeneProduct ncbigene:5567
PRKAR2A GeneProduct ncbigene:5576
GNB5 GeneProduct ncbigene:10681
KCNJ3 GeneProduct ncbigene:3760
PLCB3 GeneProduct ncbigene:5331
AKAP7 GeneProduct ncbigene:9465
GNA13 GeneProduct ncbigene:10672
ADCY6 GeneProduct ncbigene:112
AKAP3 GeneProduct ncbigene:10566
PDE1A GeneProduct ncbigene:5136
PDE1C GeneProduct ncbigene:5137
ADCY2 GeneProduct ncbigene:108
GNAO1 GeneProduct ncbigene:2775
GNAL GeneProduct ncbigene:2774
PRKD1 GeneProduct ncbigene:5587
PRKD3 GeneProduct ncbigene:23683
ADCY9 GeneProduct ncbigene:115
AKAP6 GeneProduct ncbigene:9472
ADCY1 GeneProduct ncbigene:107
PPP3CC GeneProduct ncbigene:5533
AKAP13 GeneProduct ncbigene:11214
GNA15 GeneProduct ncbigene:2769
PDE8A GeneProduct ncbigene:5151
AKAP12 GeneProduct ncbigene:9590
RHOA GeneProduct ncbigene:387
AKAP4 GeneProduct ncbigene:8852
GNAI3 GeneProduct ncbigene:2773
AKAP11 GeneProduct ncbigene:11215
GNGT2 GeneProduct ncbigene:2793
PRKCQ GeneProduct ncbigene:5588
AKAP2 GeneProduct ncbigene:11217
PDE4C GeneProduct ncbigene:5143
GNG8 GeneProduct ncbigene:94235
PRKCE GeneProduct ncbigene:5581
GNG7 GeneProduct ncbigene:2788
PRKCG GeneProduct ncbigene:5582
GNB1 GeneProduct ncbigene:2782
PRKCA GeneProduct ncbigene:5578
PRKCI GeneProduct ncbigene:5584
GNG5 GeneProduct ncbigene:2787
GNG3 GeneProduct ncbigene:2785
HRAS GeneProduct ncbigene:3265
PRKCZ GeneProduct ncbigene:5590
ARHGEF1 GeneProduct ncbigene:9138
AKAP10 GeneProduct ncbigene:11216
GNAI1 GeneProduct ncbigene:2770
ADCY8 GeneProduct ncbigene:114
ADCY7 GeneProduct ncbigene:113
PRKACA GeneProduct ncbigene:5566
PDE4B GeneProduct ncbigene:5142
KRAS GeneProduct ncbigene:3845
PDE7A GeneProduct ncbigene:5150
AKAP9 GeneProduct ncbigene:10142
GNG4 GeneProduct ncbigene:2786
GNA12 GeneProduct ncbigene:2768
ITPR1 GeneProduct ncbigene:3708
PRKACG GeneProduct ncbigene:5568
SLC9A1 GeneProduct ncbigene:6548
GNAI2 GeneProduct ncbigene:2771


  1. G proteins: a family of signal transducers. Stryer L, Bourne HR. Annu Rev Cell Biol. 1986;2:391–419. PubMed Europe PMC Scholia
  2. G protein pathways. Neves SR, Ram PT, Iyengar R. Science. 2002 May 31;296(5573):1636–9. PubMed Europe PMC Scholia