Neural crest differentiation (WP3273)

Bos taurus

Gene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involved involved in neural crest and downstream progenitor specification. Transcriptional regulation arrows are proposed to promote transcription, unless a graphical T-bar is present at the end of the arrow (commented to be inhibitors of transcriptional regulation). Additional gene information was obtained from http://www.ncbi.nlm.nih.gov/books/NBK53143 When citing thies pathway, please reference the source publication (PMID: 19575671).

Authors

Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Cell Type Ontology

migratory cranial neural crest cell neural crest derived neuron

Participants

Label Type Compact URI Comment
BMP7 GeneProduct ensembl:ENSBTAG00000015362 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101144
RHOB GeneProduct ensembl:ENSBTAG00000046054 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143878
MYB GeneProduct ensembl:ENSBTAG00000012074 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118513
ITGB1 GeneProduct ensembl:ENSBTAG00000015910 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150093
WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125084
TFAP2A GeneProduct ensembl:ENSBTAG00000001250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137203
ZIC1 GeneProduct ensembl:ENSBTAG00000014751 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152977
PAX3 GeneProduct ensembl:ENSBTAG00000009950 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135903
PAX7 GeneProduct ensembl:ENSBTAG00000014967 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000009709
DLX5 GeneProduct ensembl:ENSBTAG00000018645 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105880
MSX1 GeneProduct ensembl:ENSBTAG00000010875 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163132
MSX2 GeneProduct ensembl:ENSBTAG00000013873 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120149
FOXD3 GeneProduct ensembl:ENSBTAG00000008501 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187140
SNAI1 GeneProduct ensembl:ENSBTAG00000014554 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124216
SNAI2 GeneProduct ensembl:ENSBTAG00000013227 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019549
WNT3A GeneProduct ensembl:ENSBTAG00000039397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154342
FZD3 GeneProduct ensembl:ENSBTAG00000006621 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104290
GSK3B GeneProduct ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000082701
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168036
TCF7L1 GeneProduct ensembl:ENSBTAG00000010111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152284
TCF7L2 GeneProduct ensembl:ENSBTAG00000016462 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196628
GBX2 GeneProduct ensembl:ENSBTAG00000008898 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168505
AXIN2 GeneProduct ensembl:ENSBTAG00000030162 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8313
AXIN1 GeneProduct ensembl:ENSBTAG00000016577 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
DVL3 GeneProduct ensembl:ENSBTAG00000019336 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
DVL2 GeneProduct ensembl:ENSBTAG00000003075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
DVL1 GeneProduct ensembl:ENSBTAG00000010696 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378
SMAD1 GeneProduct ensembl:ENSBTAG00000002835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170365
ID1 GeneProduct ensembl:ENSBTAG00000016169 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125968
NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
DLL3 GeneProduct ensembl:ENSBTAG00000010483 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090932
NOTCH4 GeneProduct ensembl:ENSBTAG00000025424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204301
NOTCH2 GeneProduct ensembl:ENSBTAG00000007909 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134250
DLL4 GeneProduct ensembl:ENSBTAG00000010361 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128917
NOTCH3 GeneProduct ensembl:ENSBTAG00000043971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000074181
DLL1 GeneProduct ensembl:ENSBTAG00000031476 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198719
HEY2 GeneProduct ensembl:ENSBTAG00000000919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135547
TWIST1 GeneProduct ensembl:ENSBTAG00000046922 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122691
SOX10 GeneProduct ensembl:ENSBTAG00000004822 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100146
FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
HES5 GeneProduct ensembl:ENSBTAG00000002483 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197921
HES1 GeneProduct ensembl:ENSBTAG00000000569 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114315
RBPJ GeneProduct ensembl:ENSBTAG00000003602 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168214
HES5 GeneProduct ensembl:ENSBTAG00000002483 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197921
HES1 GeneProduct ensembl:ENSBTAG00000000569 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114315
FGFR1 GeneProduct ensembl:ENSBTAG00000015457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077782
FGFR2 GeneProduct ensembl:ENSBTAG00000014064 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066468
FGFR3 GeneProduct ensembl:ENSBTAG00000007164 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000068078
ZIC5 GeneProduct ensembl:ENSBTAG00000046271 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139800
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
SOX9 GeneProduct ensembl:ENSBTAG00000045824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125398
SOX10 GeneProduct ensembl:ENSBTAG00000004822 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100146
ISL1 GeneProduct ensembl:ENSBTAG00000001241 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000016082
CDH6 GeneProduct ensembl:ENSBTAG00000012992 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113361
CDH2 GeneProduct ensembl:ENSBTAG00000021190 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170558
E-CADHERIN GeneProduct ensembl:ENSBTAG00000015991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000039068
SOX5 GeneProduct ensembl:ENSBTAG00000022360 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134532
ETS1 GeneProduct ensembl:ENSBTAG00000002341 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134954
PAX3 GeneProduct ensembl:ENSBTAG00000009950 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135903
PAX7 GeneProduct ensembl:ENSBTAG00000014967 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000009709
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109320
CDH7 GeneProduct ensembl:ENSBTAG00000014488 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081138
TFAP2A GeneProduct ensembl:ENSBTAG00000001250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137203
SNAI1 GeneProduct ensembl:ENSBTAG00000014554 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124216
SNAI2 GeneProduct ensembl:ENSBTAG00000013227 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019549
FOXD3 GeneProduct ensembl:ENSBTAG00000008501 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187140
ID1 GeneProduct ensembl:ENSBTAG00000016169 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125968
SOX9 GeneProduct ensembl:ENSBTAG00000045824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125398
NFKB2 GeneProduct ensembl:ENSBTAG00000006017 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077150
NEUROG1 GeneProduct ensembl:ENSBTAG00000003331 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181965
SOX10 GeneProduct ensembl:ENSBTAG00000004822 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100146
PHOX2B GeneProduct ensembl:ENSBTAG00000044166 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109132
GFAP GeneProduct ensembl:ENSBTAG00000013534 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131095
OLIG1 GeneProduct ensembl:ENSBTAG00000037547 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184221
GJB1 GeneProduct ensembl:ENSBTAG00000020512 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169562
ASCL1 GeneProduct ensembl:ENSBTAG00000016227 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139352
MITF GeneProduct ensembl:ENSBTAG00000006679 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187098
PMP22 GeneProduct ensembl:ENSBTAG00000019070 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109099
MPZ GeneProduct ensembl:ENSBTAG00000033835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158887
MBP GeneProduct ensembl:ENSBTAG00000022890 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
FOXD3 GeneProduct ensembl:ENSBTAG00000008501 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187140
PAX3 GeneProduct ensembl:ENSBTAG00000009950 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135903
LHX1 GeneProduct ensembl:ENSBTAG00000033562 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000273706
LHX2 GeneProduct ensembl:ENSBTAG00000010990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106689
BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125378
FGF8 GeneProduct ensembl:ENSBTAG00000001530 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107831
FGF19 GeneProduct ensembl:ENSBTAG00000017285 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162344
SOX10 GeneProduct ensembl:ENSBTAG00000004822 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100146
PAX3 GeneProduct ensembl:ENSBTAG00000009950 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135903
PAX7 GeneProduct ensembl:ENSBTAG00000014967 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000009709
SOX5 GeneProduct ensembl:ENSBTAG00000022360 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134532
MITF GeneProduct ensembl:ENSBTAG00000006679 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187098
HDAC1 GeneProduct ensembl:ENSBTAG00000012698 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116478
HDAC2 GeneProduct ensembl:ENSBTAG00000011849 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196591
HDAC3 GeneProduct ensembl:ENSBTAG00000017360 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171720
HDAC4 GeneProduct ensembl:ENSBTAG00000017764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000068024
HDAC5 GeneProduct ensembl:ENSBTAG00000016254 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108840
HDAC6 GeneProduct ensembl:ENSBTAG00000013244 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000094631
HDAC7 GeneProduct ensembl:ENSBTAG00000026819 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000061273
HDAC8 GeneProduct ensembl:ENSBTAG00000046092 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147099
HDAC9 GeneProduct ensembl:ENSBTAG00000003808 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000048052
HDAC10 GeneProduct ensembl:ENSBTAG00000011000 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100429
HDAC11 GeneProduct ensembl:ENSBTAG00000007208 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163517
CTBP2 GeneProduct ensembl:ENSBTAG00000003397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175029
DCT GeneProduct ensembl:ENSBTAG00000002300 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080166
SOX5 GeneProduct ensembl:ENSBTAG00000022360 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134532
SOX9 GeneProduct ensembl:ENSBTAG00000045824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125398
COL2A1 GeneProduct ensembl:ENSBTAG00000013155 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139219
COL11A2 GeneProduct ensembl:ENSBTAG00000000601 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204248
MIA GeneProduct ensembl:ENSBTAG00000009078 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8190
WNT8A GeneProduct ensembl:ENSBTAG00000005570 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000061492
HOXB1 GeneProduct ensembl:ENSBTAG00000007603 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120094
PRTG GeneProduct ensembl:ENSBTAG00000005848 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166450
OLIG3 GeneProduct ensembl:ENSBTAG00000008749 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177468
TBX6 GeneProduct ensembl:ENSBTAG00000009046 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000149922
HOXA1 GeneProduct ensembl:ENSBTAG00000013263 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105991
LHX5 GeneProduct ensembl:ENSBTAG00000003107 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089116
TLX2 GeneProduct ensembl:ENSBTAG00000016607 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115297
TFAP2B GeneProduct ensembl:ENSBTAG00000020426 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000008196
DMBX1 GeneProduct ensembl:ENSBTAG00000009625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197587
HAND1 GeneProduct ensembl:ENSBTAG00000002335 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113196

References

  1. Hoxb1 neural crest preferentially form glia of the PNS. Arenkiel BR, Gaufo GO, Capecchi MR. Dev Dyn. 2003 Jul;227(3):379–86. PubMed Europe PMC Scholia
  2. Reiterated Wnt signaling during zebrafish neural crest development. Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, et al. Development. 2004 Mar;131(6):1299–308. PubMed Europe PMC Scholia
  3. The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord. Filippi A, Tiso N, Deflorian G, Zecchin E, Bortolussi M, Argenton F. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4377–82. PubMed Europe PMC Scholia
  4. AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo. Knight RD, Javidan Y, Zhang T, Nelson S, Schilling TF. Development. 2005 Jul;132(13):3127–38. PubMed Europe PMC Scholia
  5. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells. Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, et al. Biochem J. 2006 Apr 15;395(2):355–61. PubMed Europe PMC Scholia
  6. Generation and maintenance of Dmbx1 gene-targeted mutant alleles. Ohtoshi A, Bradley A, Behringer RR, Nishijima I. Mamm Genome. 2006 Jul;17(7):744–50. PubMed Europe PMC Scholia
  7. Assembling neural crest regulatory circuits into a gene regulatory network. Betancur P, Bronner-Fraser M, Sauka-Spengler T. Annu Rev Cell Dev Biol. 2010;26:581–603. PubMed Europe PMC Scholia
  8. A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus. Callery EM, Thomsen GH, Smith JC. Dev Biol. 2010 Apr 1;340(1):75–87. PubMed Europe PMC Scholia
  9. Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar. Takahashi KF, Kiyoshima T, Kobayashi I, Xie M, Yamaza H, Fujiwara H, et al. BMC Dev Biol. 2010 Nov 25;10:115. PubMed Europe PMC Scholia
  10. Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Makki N, Capecchi MR. Dev Biol. 2011 Sep 15;357(2):295–304. PubMed Europe PMC Scholia