SARS-CoV-2 innate immunity evasion and cell-specific immune response (WP5039)

Homo sapiens

SARS-CoV-2 Innate immunity evasion mechanisms and cell-specific immune responses; Metabolic overview over ATII cells infection


Mario Alin Rus , Egon Willighagen , Nuray Talih , Martina Summer-Kutmon , Friederike Ehrhart , Eric Weitz , Nhung Pham , and Lars Willighagen


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Homo sapiens




Disease Ontology

severe acute respiratory syndrome COVID-19

Pathway Ontology

disease pathway immune response pathway


Label Type Compact URI Comment
Interferon gamma-1b Metabolite wikidata:Q582356
CXCL2 GeneProduct ncbigene:2920
CXCL3 GeneProduct ensembl:ENSG00000163734
CXCL4 GeneProduct ensembl:ENSG00000163737
CXCL5 GeneProduct ensembl:ENSG00000163735
CXCL6 GeneProduct ncbigene:6372
CXCL7 GeneProduct ensembl:ENSG00000163736
CXCL8 GeneProduct ensembl:ENSG00000169429
CXCL9 GeneProduct ensembl:ENSG00000138755
CXCL10 GeneProduct ensembl:ENSG00000169245
CXCL11 GeneProduct ensembl:ENSG00000169248
CXCL12 GeneProduct ensembl:ENSG00000107562
CXCL13 GeneProduct ensembl:ENSG00000156234
IFN-III GeneProduct pfam:PF15177
CXCL1 GeneProduct ensembl:ENSG00000163739
HDAC2 GeneProduct ensembl:ENSG00000196591
CXCR2 GeneProduct ensembl:ENSG00000180871
TRAF3 GeneProduct ensembl:ENSG00000131323
MX1 GeneProduct ncbigene:4599
IFNB1 GeneProduct ensembl:ENSG00000171855
CD16 GeneProduct ensembl:ENSG00000117281
CCL2 GeneProduct ensembl:ENSG00000108691
MAVS GeneProduct ensembl:ENSG00000088888
TFAP2A GeneProduct ensembl:ENSG00000137203
TRAF6 GeneProduct ensembl:ENSG00000175104
IFN-I GeneProduct ncbigene:3438
RAE1 GeneProduct ensembl:ENSG00000101146
TLR7 GeneProduct ensembl:ENSG00000196664
IRF7 GeneProduct ensembl:ENSG00000185507
CXCL8 GeneProduct ensembl:ENSG00000169429
LAG3 GeneProduct ncbigene:3902
ACE2 GeneProduct ensembl:ENSG00000130234
KIR GeneProduct ensembl:ENSG00000104970
TRIM25 GeneProduct ensembl:ENSG00000121060
LGP2 GeneProduct ensembl:ENSG00000108771
TBK1 GeneProduct ensembl:ENSG00000183735
SMAD3 GeneProduct ensembl:ENSG00000166949
CXCL2 GeneProduct ensembl:ENSG00000081041
NFKB GeneProduct ensembl:ENSG00000109320
CCL5 GeneProduct ensembl:ENSG00000271503
TRADD GeneProduct ensembl:ENSG00000102871
IFITM1 GeneProduct ncbigene:8519
FADD GeneProduct ensembl:ENSG00000168040
NUP98 GeneProduct ensembl:ENSG00000110713
P53 GeneProduct ensembl:ENSG00000115129
TRAF2 GeneProduct ensembl:ENSG00000127191
CCL3 GeneProduct ensembl:ENSG00000277632
SMAD3 GeneProduct ensembl:ENSG00000166949
RIPK1 GeneProduct ensembl:ENSG00000137275
TANK GeneProduct ensembl:ENSG00000136560
STAT2 GeneProduct ensembl:ENSG00000170581
IFIT2 GeneProduct ncbigene:3433
P300 GeneProduct ensembl:ENSG00000100393
TGFB1 GeneProduct ensembl:ENSG00000105329
LARP1 GeneProduct ensembl:ENSG00000155506
IRF3 GeneProduct ensembl:ENSG00000126456
TRAF5 GeneProduct ensembl:ENSG00000082512
HAVCR2 GeneProduct ncbigene:84868 TIM3
CCL4 GeneProduct ensembl:ENSG00000275302
NFKB GeneProduct ensembl:ENSG00000109320
IRF3 GeneProduct ensembl:ENSG00000126456
IRF7 GeneProduct ensembl:ENSG00000185507
ACE2 GeneProduct ensembl:ENSG00000130234
DDX58 GeneProduct ensembl:ENSG00000107201 Binds to 5' PPP RNA region
CXCL17 GeneProduct ensembl:ENSG00000189377
IFIT2 GeneProduct ncbigene:3433
IFN-I GeneProduct pfam:PF00143
RIPK1 GeneProduct ensembl:ENSG00000137275
IFN-III GeneProduct pfam:PF15177
S1 Protein wikidata:Q106020256
nsp13 Protein uniprot:6ZSL
orf9b Protein uniprot:P0DTD2
AP-1 Protein uniprot:B3KNW1
IFNAR1 Protein ensembl:ENSG00000142166
nsp12 Protein wikidata:Q94647436
orf3b Protein uniprot:YP_009825053
N Protein uniprot:P0DTC9
orf3a Protein uniprot:P0DTC3
IL-6R Protein uniprot:A0N0L5
IL-10 Protein uniprot:P22301
IL-6 Protein uniprot:B4DNV3
STAT1 Protein ensembl:ENSG00000115415
BSG Protein uniprot:P35613 Basigin
nsp5 Protein uniprot:Q87917582
IFNAR2 Protein ensembl:ENSG00000159110
NKG2A Protein ncbiprotein:AAL65234
N Protein uniprot:P0DTC9
orf6 Protein uniprot:Q89226299
TNF Protein uniprot:P01375
CSF2 Protein uniprot:P04141 GM-CSF
M Protein uniprot:P0DTC5
nsp15 Protein uniprot:Q87917579
JAK1 Protein ensembl:ENSG00000162434
MDA5 Protein ncbigene:424185
CASP8 Protein uniprot:Q14790 Caspase-8
N Protein uniprot:P0DTC9
M Protein uniprot:P0DTC5
AP-1 Protein uniprot:B3KNW1
IL-6R Protein uniprot:A0N0L5
nsp10 Protein uniprot:YP_009742617
IL-6R Protein uniprot:A0N0L5
orf3a Protein uniprot:P0DTC3
orf9b Protein uniprot:P0DTD2
nsp4 Protein ncbiprotein:YP_009742611
N Protein uniprot:P0DTC9
N Protein uniprot:P0DTC9
MX1 Protein ncbigene:4599
IFITM1 Protein ncbigene:8519


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