SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction (WP5183)
Homo sapiens
Long COVID-19 (Coronavirus disease) ranges from lingering symptoms 6-12 months after contracting COVID-19 to severe implications caused by the virus. To understand the (molecular) mechanisms underlying Long COVID-19 and the potential role of chronic oxidative stress, this pathway concisely visualises mitochondrial hijacking by SARS-COV-2 leading to pro-senescent mitochondrial dysfunction and inflammation.
Authors
Kingson ''junsheng Thang'' Luc , Martina Summer-Kutmon , Celine Malyar , Jing Jing Cai , Egon Willighagen , and Isabel WassinkActivity
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
signaling pathway oxidative stress response pathwayDisease Ontology
COVID-19| Label | Type | Compact URI | Comment |
|---|---|---|---|
| MtROS | Metabolite | chebi:26523 | |
| PGC1 | Metabolite | chebi:15546 | |
| Angiotensin I | Metabolite | chebi:2718 | |
| Angiotensin II | Metabolite | chebi:2719 | |
| Angiotensin-(1-9) | Metabolite | chebi:80128 | |
| Angiotensin (1-7) | Metabolite | chebi:55438 | |
| NDUFAF2 | GeneProduct | ensembl:ENSG00000164182 | |
| NLRP3 | GeneProduct | ensembl:ENSG00000162711 | |
| TERF2IP | GeneProduct | ensembl:ENSG00000166848 | |
| SIRT6 | GeneProduct | ensembl:ENSG00000077463 | |
| NDUFAF1 | GeneProduct | ensembl:ENSG00000137806 | |
| NF-kB | GeneProduct | ensembl:ENSG00000109320 | |
| TERF2 | GeneProduct | ensembl:ENSG00000132604 | |
| ACAD9 | GeneProduct | ensembl:ENSG00000177646 | |
| ECSIT | GeneProduct | ensembl:ENSG00000130159 | |
| BCS1KL | GeneProduct | ensembl:ENSG00000074582 | |
| NLRX1 | GeneProduct | ensembl:ENSG00000160703 | |
| MAVS | GeneProduct | ensembl:ENSG00000088888 | |
| TOMM70 | GeneProduct | ensembl:ENSG00000154174 | |
| TRAF3 | GeneProduct | ensembl:ENSG00000131323 | |
| TRAF6 | GeneProduct | ensembl:ENSG00000175104 | |
| NFIP2 | GeneProduct | uniprot:Q9NV92 | |
| RIG-I | GeneProduct | uniprot:095786 | |
| PHB1 | GeneProduct | uniprot:P35232 | |
| NOX1 | GeneProduct | uniprot:Q9Y5S8 | |
| TMEM173 | GeneProduct | uniprot:Q86WV6 | |
| ACE2 | GeneProduct | uniprot:Q9BYF1 | |
| AGT | GeneProduct | uniprot:P01019 | |
| ACE | GeneProduct | uniprot:P12821 | |
| Renin | GeneProduct | uniprot:P00797 | |
| p90rsk | Protein | uniprot:E9PGT3 | |
| IL-18 | Protein | uniprot:Q14116 | |
| IL-6 | Protein | uniprot:P05231 | |
| nsp7 | Protein | uniprot:P0DTD1 | |
| IL-1β | Protein | chebi:138181 | |
| TNF | Protein | uniprot:Q5STB3 | |
| orf9c | Protein | uniprot:P0DTD3 | |
| orf9b | Protein | uniprot:P0DTD2 | |
| nsp2 | Protein | ncbiprotein:YP_009725298 |
References
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- The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV. Hemmat N, Asadzadeh Z, Ahangar NK, Alemohammad H, Najafzadeh B, Derakhshani A, et al. Arch Virol. 2021 Mar;166(3):675–96. PubMed Europe PMC Scholia
- SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress. Chang R, Mamun A, Dominic A, Le NT. Front Physiol. 2021 Jan 15;11:605908. PubMed Europe PMC Scholia