SARS-CoV-2 replication organelle formation (WP5156)

Homo sapiens

Components of the class III PI3K complex is speculated to promote SARS-CoV-2 replication. PI3P and DFCP1 contribute to the formation of double membrane vesicles needed for viral replication. Nsp3 protein from SARS-CoV 2 stimulates the accumulation of PI3P.

Authors

Nhung Pham , Eric Weitz , Egon Willighagen , and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

COVID-19

Pathway Ontology

infectious disease pathway disease pathway

Participants

Label Type Compact URI Comment
PI3P Metabolite chebi:26034
Beclin-1 Protein uniprot:Q14457
VPS15 Protein uniprot:Q99570
VPS34 Protein uniprot:Q8NEB9
AMBRA Protein uniprot:Q9C0C7
ATG14 Protein uniprot:Q6ZNE5
DFCP1 Protein uniprot:Q9HBF4
nsp3 Protein ncbiprotein:YP_009725299
rep 1ab Protein uniprot:P0DTD1

References

  1. Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation. Twu WI, Lee JY, Kim H, Prasad V, Cerikan B, Haselmann U, et al. Cell Rep. 2021 Nov 23;37(8):110049. PubMed Europe PMC Scholia