PtdIns(4,5)P2 in cytokinesis pathway (WP5199)

Homo sapiens

Phosphatidylinositol 4,5-bisphosphate -- also known as PtdIns(4,5)P2 or PIP2 or PI(4,5)P2 -- acts as a central component in the process of bridge stability during the final steps of cytokinesis. Furthermore, PtdIns(4,5)P2 shows bidirectional interactions with many different metabolites such as anillin, ERM-complex. But also Septin2, F-actin and other depicted components visualized in the pathway are required to finalize cytokinesis between two sister cells.


Soukaina Boudllali , Denise Slenter , Eric Weitz , and Lars Willighagen


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Homo sapiens



Pathway Ontology

signaling pathway phosphatidylinositol metabolic pathway lipid signaling pathway cell cycle pathway


Label Type Compact URI Comment
PtdIns(4,5)P2 Metabolite chebi:83419
PtdIns(4,5)P2 Metabolite chebi:83419
CDP-DAG Metabolite chebi:17962
PtdIns(3,4,5)P3 Metabolite chebi:83416
PCL Metabolite chebi:53200
RhoA GeneProduct ensembl:ENSG00000067560
AFAP1 Protein uniprot:Q8N556
KIF23 Protein uniprot:Q02241
Septin-2 Protein uniprot:Q15019
Ezrin Protein uniprot:P15311
OCLR1 Protein uniprot:Q01968
Anillin Protein uniprot:Q9NQW6
MYL2 Protein uniprot:Q6IB42
Radixin Protein uniprot:P35241
RACGAP1 Protein uniprot:Q9H0H5
Moesin Protein uniprot:P26038
RAB35 Protein uniprot:Q15286


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  2. Organizing the cell cortex: the role of ERM proteins. Fehon RG, McClatchey AI, Bretscher A. Nat Rev Mol Cell Biol. 2010 Apr;11(4):276–87. PubMed Europe PMC Scholia
  3. Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis. Dambournet D, Machicoane M, Chesneau L, Sachse M, Rocancourt M, El Marjou A, et al. Nat Cell Biol. 2011 Jun 26;13(8):981–8. PubMed Europe PMC Scholia
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