Acetylcholine synthesis (WP264)

Caenorhabditis elegans

Acetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and acetate, this is essential for proper neuronal functioning. Choline and Acetate are taken up into the cytosol and recycled for the next activation.


Andrew Kwa , Thomas Kelder , Christian Grove , Christine Chichester , Martina Summer-Kutmon , Friederike Ehrhart , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Caenorhabditis elegans




Pathway Ontology

acetylcholine metabolic pathway


Label Type Compact URI Comment
Phosphatidylethanolamines Metabolite chebi:16038
Cytidine diphosphate choline Metabolite chebi:16436
Phosphatidylcholines Metabolite chebi:49183
Phosphorylcholine Metabolite chebi:49183
Glycerophosphocholine Metabolite chebi:16870
Choline Metabolite chebi:15354
Acetylcholine Metabolite chebi:15355
Choline Metabolite chebi:15354
Acetate Metabolite chebi:30089
Acetyl CoA Metabolite chebi:15351
PDHA-1 GeneProduct ncbigene:3565996
PCYT-1 GeneProduct wormbase:WBGene00017241
PMT-1 GeneProduct wormbase:WBGene00022781
UNC-17 GeneProduct ncbigene:177124
ace-1 GeneProduct ncbigene:181706
CKA-2 Protein ncbigene:180703


  1. Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. PubMed Europe PMC Scholia