Photodynamic therapy-induced HIF-1 survival signaling (WP3614)

Homo sapiens

Photodynamic therapy may induce a hypoxic survival response mediated by HIF-1. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Ruud Weijer , Kristina Hanspers , Friederike Ehrhart , and Martina Summer-Kutmon


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Homo sapiens




Disease Ontology


Pathway Ontology

altered regulatory pathway


Label Type Compact URI Comment
ARNT GeneProduct ncbigene:405
PFKL GeneProduct ncbigene:5211
SLC16A1 GeneProduct ncbigene:6566
LDHA GeneProduct ncbigene:3939
HIF1AN GeneProduct ncbigene:55662
PKM2 GeneProduct ncbigene:5315
PGK1 GeneProduct ncbigene:5230
SLC2A1 GeneProduct ncbigene:6513
EGLN1 GeneProduct ncbigene:54583
HK1 GeneProduct ncbigene:3098
SLC2A3 GeneProduct ncbigene:6515
HIF1A GeneProduct ncbigene:3091
HIF1A GeneProduct ncbigene:3091
SERPINE1 GeneProduct ncbigene:5054
EDN1 GeneProduct ncbigene:1906
NOS2 GeneProduct ncbigene:4843
PTGS2 GeneProduct ncbigene:5743
ANGPT1 GeneProduct ncbigene:284
VEGFA GeneProduct ncbigene:7422
IGFBP1 GeneProduct ncbigene:3484
IGFBP2 GeneProduct ncbigene:3485
VEGFA GeneProduct ncbigene:7422
TGFA GeneProduct ncbigene:7039
TGFB3 GeneProduct ncbigene:7043
IGFBP3 GeneProduct ncbigene:3486
TGFB3 GeneProduct ncbigene:7043
TGFA GeneProduct ncbigene:7039
EPO GeneProduct ncbigene:2056
ANGPT2 GeneProduct ncbigene:285
BIRC5 GeneProduct ncbigene:332
PTGS2 GeneProduct ncbigene:5743
BCL2A1 GeneProduct ncbigene:597
MCL1 GeneProduct ncbigene:4170
BCL2L1 GeneProduct ncbigene:598
BNIP3 GeneProduct ncbigene:664
BNIP3L GeneProduct ncbigene:665
BID GeneProduct ncbigene:637
PMAIP1 GeneProduct ncbigene:5366
TP53 GeneProduct ncbigene:7157
BAX GeneProduct ncbigene:581
BAK1 GeneProduct ncbigene:578
PDHA1 Protein uniprot:P08559


  1. Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M. Cancer Metastasis Rev. 2015 Dec;34(4):643–90. PubMed Europe PMC Scholia
  2. Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, et al. BMC Cancer. 2015 Dec 26;15:1014. PubMed Europe PMC Scholia