Metabolic epileptic disorders (WP5355)

Homo sapiens

A network pathway of nine metabolic epileptic disorders

Authors

Bhavana Kapalli , Aishwarya Iyer , Egon Willighagen , Javier Millán Acosta , Kristina Hanspers , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

molybdenum cofactor deficiency pathway neuropsychiatric disease pathway metabolic disease pathway Glut1 deficiency syndrome pathway

Disease Ontology

epilepsy

Participants

Label Type Compact URI Comment
citrate Metabolite chebi:16947
Glycine Metabolite hmdb:HMDB0000123
8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid Metabolite hmdb:HMDB13639
Allysine Metabolite hmdb:HMDB01263
MoCo Metabolite chebi:60525
L-cysteine Metabolite chebi:17561
Biotinyl-5'-AMP Metabolite hmdb:HMDB04220
L-glutamic acid Metabolite chebi:16015
Ammonia Metabolite hmdb:HMDB00051
Phosphate Metabolite hmdb:HMDB01429
Crotonoyl-CoA Metabolite chebi:15473
L-serine Metabolite chebi:33384
Allysine Metabolite hmdb:HMDB01263
Sulfate Metabolite hmdb:HMDB0001448
Acetoacetyl-CoA Metabolite hmdb:HMDB01484
Homocysteine Metabolite hmdb:HMDB00742
Glutathione perfsulfide Metabolite chebi:58905
Oxoadipic acid Metabolite hmdb:HMDB00225
Biocytin Metabolite hmdb:HMDB0003134
L-Pipecolic acid Metabolite hmdb:HMDB00716
Uric acid Metabolite chebi:17775
NAD Metabolite hmdb:HMDB00902
Biocytin Metabolite hmdb:HMDB0003134
Glutaryl-CoA Metabolite chebi:15524
Orotidylic acid Metabolite hmdb:HMDB00218
GTP Metabolite chebi:37565
Hydrogen sulfide Metabolite hmdb:HMDB03276
zinc Metabolite chebi:27363
Cysteine sulfinic acid Metabolite hmdb:HMDB0250705
Phosphoserine Metabolite chebi:15811
2-oxoglutarate Metabolite chebi:16810
Biotin Metabolite hmdb:HMDB00030
2-Ketobutyric acid Metabolite hmdb:HMDB00005
Aminoadipic acid Metabolite hmdb:HMDB00510
Guanidoacetic acid Metabolite hmdb:HMDB00128
Ornithine Metabolite hmdb:HMDB00214
Saccharopine Metabolite hmdb:HMDB00279
3-Hydroxybutyryl-CoA Metabolite hmdb:HMDB01166
hypoxanthine Metabolite chebi:17368
5,10-Methylene-THF Metabolite hmdb:HMDB01533
L-alanine Metabolite chebi:16977
3-Sulfinylpyruvic acid Metabolite hmdb:HMDB01405
sulfite Metabolite chebi:17359
(S)-2,3,4,5-tetrahydropyridine-2-carboxylic acid Metabolite chebi:49014
L-Glutamine Metabolite hmdb:HMDB00641
xanthine Metabolite chebi:15318
L-cystathionine Metabolite chebi:17482
Citrulline Metabolite hmdb:HMDB00904
Pyridoxal 5'-phosphate Metabolite hmdb:HMDB01491
Argininosuccinic acid Metabolite hmdb:HMDB00052
L-lysine Metabolite chebi:29967
Oxoglutaric acid Metabolite hmdb:HMDB00208
Cysteine Metabolite chebi:15356
L-lysine Metabolite chebi:29967
L-lysine Metabolite chebi:29967
Water Metabolite hmdb:HMDB0002111
NADPH Metabolite hmdb:HMDB0000221
NADP Metabolite hmdb:HMDB0000217
Oxoglutaric acid Metabolite chebi:30915
Water Metabolite hmdb:HMDB0002111
NADPH Metabolite hmdb:HMDB0000221
NADP Metabolite hmdb:HMDB0000217
L-Glutamic acid Metabolite hmdb:HMDB00148
FAD Metabolite chebi:16238 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103485
Oxygen Metabolite chebi:25805
Hydrogen peroxide Metabolite hmdb:HMDB03125
Water Metabolite hmdb:HMDB02111
NADPH Metabolite hmdb:HMDB0000221
NADP Metabolite hmdb:HMDB0000217
Water Metabolite hmdb:HMDB02111
L-lysine Metabolite chebi:18019
Water Metabolite hmdb:HMDB02111
Biotin Metabolite hmdb:HMDB00030
Pyrophosphate Metabolite hmdb:HMDB00250
ATP Metabolite chebi:30616
Carbon dioxide Metabolite hmdb:HMDB01967
(R)-Lipoic acid Metabolite hmdb:HMDB01451
Dihydrolipoate Metabolite hmdb:HMDB12210
NADH Metabolite hmdb:HMDB01487
L-arginine Metabolite chebi:29952
S-Adenosylhomocysteine Metabolite hmdb:HMDB00939
S-Adenosylmethionine Metabolite hmdb:HMDB01185
Creatine Metabolite chebi:16919
Fumaric acid Metabolite hmdb:HMDB00134
AMP Metabolite hmdb:HMDB0000045
ATP Metabolite chebi:30616
NADP Metabolite hmdb:HMDB0000217
L-aspartic acid Metabolite chebi:17053
Urea Metabolite chebi:16199
Water Metabolite hmdb:HMDB02111
Ornithine Metabolite hmdb:HMDB00214
Citrulline Metabolite hmdb:HMDB00904
Carbamoyl phosphate Metabolite hmdb:HMDB01096
Phosphate Metabolite hmdb:HMDB0002142
Phosphoric acid Metabolite hmdb:HMDB0002142
Water Metabolite hmdb:HMDB02111
ADP Metabolite hmdb:HMDB0001341
ATP Metabolite hmdb:HMDB0000538
Ammonia Metabolite hmdb:HMDB00051
L-Glutamine Metabolite hmdb:HMDB00641
Water Metabolite hmdb:HMDB0002111
Hydrogen Ion Metabolite hmdb:HMDB0059597
L-alanine Metabolite chebi:16977
NAD Metabolite hmdb:HMDB0000902
Water Metabolite hmdb:HMDB0002111
NADH Metabolite chebi:16908
L-Glutamic acid Metabolite hmdb:HMDB00148
Oxoglutaric acid Metabolite chebi:30915
Coenzyme A Metabolite hmdb:HMDB01423
Carbon dioxide Metabolite hmdb:HMDB01967
Water Metabolite hmdb:HMDB02111
NAD Metabolite hmdb:HMDB0000902
NADH Metabolite chebi:16908
Coenzyme A Metabolite hmdb:HMDB01423
Oxaloacetate Metabolite hmdb:HMDB0000223
Acetyl-CoA Metabolite hmdb:HMDB0001206
Pyruvate Metabolite hmdb:HMDB0000243
Malate Metabolite hmdb:HMDB0000744
Aspartate Metabolite hmdb:HMDB0000191
Malate Metabolite hmdb:HMDB0000744
2P-Glycerate Metabolite hmdb:HMDB0000362
Oxaloacetate Metabolite hmdb:HMDB0000223
1,3BP-Glycerate Metabolite hmdb:HMDB0001270
3P-Glycerate Metabolite hmdb:HMDB0000807
Fructose-1,6BP Metabolite hmdb:HMDB0001058
Lactate Metabolite hmdb:HMDB0000190
Glucose Metabolite hmdb:HMDB0000122
Glyceraldehyde 3P Metabolite hmdb:HMDB0001112
Pyruvate Metabolite hmdb:HMDB0000243
Fructose 6P Metabolite chebi:61527
Glucose Metabolite hmdb:HMDB0000122
Dihydroxyacetone-P Metabolite hmdb:HMDB0001473
P-enolpyruvate Metabolite hmdb:HMDB0000263
Aspartate Metabolite hmdb:HMDB0000191
Glucose-6P Metabolite chebi:75052 Glucose-6-Phosphate (2-)
Glucose-6P (open) Metabolite chebi:57584 D-Glucose-6-Phosphate (2-) open form
Fructose 6P (open) Metabolite chebi:57579 fructose-6-phosphate (2-) open form
citrate Metabolite chebi:16947
L-serine Metabolite chebi:33384
Phosphohydroxypyruvic acid Metabolite hmdb:HMDB01024
Water Metabolite hmdb:HMDB0002111
Water Metabolite hmdb:HMDB0002111
Water Metabolite hmdb:HMDB0002111
sulfite Metabolite chebi:17359
MOCS1 GeneProduct ensembl:ENSG00000124615
GLDC GeneProduct uniprot:P23378
SPCS1 GeneProduct uniprot:Q9Y6A9
SLC25A15 GeneProduct uniprot:Q9Y619
SLC1A5 GeneProduct uniprot:Q15758
AASS GeneProduct uniprot:A4D0W4 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
ALDH7A1 GeneProduct ensembl:ENSG00000164904 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
HLCS GeneProduct uniprot:P50747 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
HLCS GeneProduct uniprot:P50747 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
GLDC GeneProduct ncbigene:2731 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151790
AMT GeneProduct ncbigene:275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183077
DLD GeneProduct ncbigene:1738 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115919
GAMT GeneProduct uniprot:Q14353 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183077
ASL GeneProduct uniprot:P04424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183077
ASS1 GeneProduct uniprot:P00966 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
ARG1 GeneProduct uniprot:P05089 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
SLC25A15 GeneProduct uniprot:Q9Y619
OTC GeneProduct uniprot:P00480 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172890
CPS1 GeneProduct uniprot:P31327 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
GLS2 GeneProduct uniprot:Q9UI32 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183077
SLC1A5 GeneProduct uniprot:Q15758
GLUD1 GeneProduct uniprot:P00367 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172890
DLD GeneProduct ncbigene:1738
PC GeneProduct ncbigene:5091
GOT2 GeneProduct ncbigene:2806
PDHA1 GeneProduct ncbigene:5160
MDH2 GeneProduct ncbigene:4191
DLAT GeneProduct ncbigene:1737
MPC2 GeneProduct ncbigene:25874
MPC1 GeneProduct ncbigene:51660
TPI1 GeneProduct ncbigene:7167
PFKP GeneProduct ncbigene:5214
FBP1 GeneProduct ncbigene:2203
ALDOA GeneProduct ncbigene:226
LDHAL6B GeneProduct ncbigene:92483
PKM1 GeneProduct ncbigene:5315
ALDOC GeneProduct ncbigene:230
SLC2A2 GeneProduct ncbigene:6514
GOT1 GeneProduct ncbigene:2805
GAPDH GeneProduct ensembl:ENSG00000111640
PFKM GeneProduct ncbigene:5213
PGK1 GeneProduct ncbigene:5230
MDH1 GeneProduct ncbigene:4190
PKLR GeneProduct ncbigene:5313
SLC2A5 GeneProduct ncbigene:6518
LDHA GeneProduct ncbigene:3939
HK1 GeneProduct ncbigene:3098
SLC2A1 GeneProduct ncbigene:6513
PGAM2 GeneProduct ncbigene:5224
PFKL GeneProduct ncbigene:5211
ENO3 GeneProduct ncbigene:2027
ENO1 GeneProduct ncbigene:2023
LDHC GeneProduct ncbigene:3948
HK3 GeneProduct ncbigene:3101
LDHB GeneProduct ncbigene:3945
ENO2 GeneProduct ncbigene:2026
G6PC GeneProduct ncbigene:2538 Not present in brain and muscle, so those organs can not produce their own glucose in the gluconeogenesis pathway
HK2 GeneProduct ncbigene:3099
PCK1 GeneProduct ncbigene:5105
PGK2 GeneProduct ncbigene:5232
SLC2A4 GeneProduct ncbigene:6517
FBP2 GeneProduct ncbigene:8789
SLC2A3 GeneProduct ncbigene:6515
GCK GeneProduct ncbigene:2645 Gck is mainly active in liver
PGAM1 GeneProduct ncbigene:5223
PKM2 GeneProduct ncbigene:5315
ALDOB GeneProduct ncbigene:229
PGI GeneProduct eccode:5.3.1.9 phosphoglucose isomerase (PGI)
GPI GeneProduct ncbigene:2821 glucose-6-phosphate isomerase
SFXN1 GeneProduct ensembl:ENSG00000164466 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183077
SHMT1 GeneProduct ensembl:ENSG00000176974 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183077
SHMT2 GeneProduct ensembl:ENSG00000182199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183077
MOCS2 GeneProduct ensembl:ENSG00000164172
GPHN GeneProduct ensembl:ENSG00000171723
MOCS3 GeneProduct ensembl:ENSG00000124217
GATM Protein uniprot:P50440
SLC25A1 Protein uniprot:P53007
XDH Protein uniprot:P47989
CDO1 Protein uniprot:Q16878
SLC7A2 Protein uniprot:P52569
GPT Protein uniprot:P24298
SUOX Protein uniprot:P51687
SLC25A5 Protein uniprot:P05141
Biotin carboxyl carrier protein Protein uniprot:Q42533
ETHE1 Protein uniprot:O95571
ACAT1 Protein uniprot:P24752
Biotinidase Protein uniprot:P43251
CBS Protein uniprot:P35520
AASS Protein uniprot:A4D0W4 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
SLC7A2 Protein uniprot:P52569
DHTKD1 Protein uniprot:H7C1J3 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
AADAT Protein uniprot:Q8N5Z0 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
GCDH Protein uniprot:Q92947 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
ECHS1 Protein uniprot:P30084 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
HADH Protein uniprot:Q16836 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117009
ACO1 Protein uniprot:P21399 glucose-6-phosphate isomerase
PSPH Protein uniprot:P78330
PSAT1 Protein uniprot:Q9Y617
PHGDH Protein uniprot:O43175
CTH Protein uniprot:P32929
SQOR Protein uniprot:Q9Y6N5
CBS Protein uniprot:P35520
XDH Protein uniprot:P47989

References

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