Sucrose biosynthesis (WP14)

Saccharomyces cerevisiae

Sucrose is synthesized from the precursors UDP-glucose and fructose 6-phosphate, which are converted into sucrose 6-phosphate by the enzyme sucrose-6-phosphate synthase. Sucrose 6-phosphate is then dephosphorylated by sucrose phosphatase, resulting in the formation of sucrose, which can be exported to other tissues. Although the reaction catalyzed by sucrose 6-phosphate synthase is energetically unfavorable, the hydrolysis of sucrose 6-phosphate to sucrose is highly exergonic, driving the overall synthesis of sucrose in an essentially irreversible manner.


Meredith Braymer , Alex Pico , Thomas Kelder , Egon Willighagen , Daniela Digles , Denise Slenter , and Eric Weitz


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Saccharomyces cerevisiae



Pathway Ontology

sucrose biosynthetic pathway


Label Type Compact URI Comment
Sucrose-6-phosphate Metabolite chebi:131603
H2O Metabolite chebi:15377
UDP Metabolite chebi:17659
UDP-D-glucose Metabolite chebi:18066
H2O Metabolite chebi:15377
UDP Metabolite chebi:17659
UTP Metabolite chebi:15713
phosphate Metabolite cas:14265-44-2
ADP Metabolite cas:58-64-0
ATP Metabolite cas:1927-31-7
phosphate Metabolite cas:14265-44-2
fructose Metabolite cas:7776-48-9
glucose-6-phosphate Metabolite cas:59-56-3
fructose-6-phosphate Metabolite cas:643-13-0
glucose-1-phosphate Metabolite chebi:16077
fructose Metabolite cas:7776-48-9
sucrose Metabolite cas:57-50-1
pyrophosphate Metabolite cas:2466-09-3
fructose-6-phosphate Metabolite cas:643-13-0
YHL012W GeneProduct ensembl:YHL012W
UGP1 GeneProduct sgd:UGP1
PGM1 GeneProduct sgd:PGM1
PGM2 GeneProduct sgd:PGM2
FBP1 GeneProduct sgd:FBP1
PGI1 GeneProduct sgd:PGI1