Cellular proteostasis (WP4918)

Homo sapiens

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In order to maintain protein homeostasis and cell function, cells are constantly synthesizing as well as degrading proteins. This is especially important when proteins are misfolded, due to extra- or intracellular stress or a genetic mutation, as this is the basis for many diseases. This pathway shows the major events which are involved in proteostasis.

Authors

Anna Baya Meuleman , Marvin Martens , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

translation pathway protein folding pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PFDN3 GeneProduct ensembl:ENSG00000155959
PFDN1 GeneProduct ensembl:ENSG00000113068
Hsp110 GeneProduct ensembl:ENST00000629751
Hsp40 GeneProduct ensembl:ENSG00000213946
Hsp90 GeneProduct ensembl:ENSG00000224411
CHIP GeneProduct ensembl:ENST00000565813.1
Hsp70 GeneProduct ensembl:ENSG00000225217
PFDN4 GeneProduct ensembl:ENSG00000101132
PFDN5 GeneProduct ensembl:ENSG00000123349
PFDN6 GeneProduct ensembl:ENSG00000204220
PFDN2 GeneProduct ensembl:ENSG00000143256
Hsp40 GeneProduct ensembl:ENSG00000213946
Hsp70 GeneProduct ensembl:ENSG00000225217
Hsp40 GeneProduct ensembl:ENSG00000213946
Hsp70 GeneProduct ensembl:ENSG00000225217
Hsp110 GeneProduct ensembl:ENST00000629751
Hsp40 GeneProduct ensembl:ENSG00000213946
Hsp70 GeneProduct ensembl:ENSG00000225217
Hsp90 GeneProduct ensembl:ENSG00000224411
Hsp70 GeneProduct ensembl:ENSG00000225217
Hsp70 GeneProduct ensembl:ENSG00000225217
Hsp90 GeneProduct ensembl:ENSG00000224411
CHIP GeneProduct ensembl:ENST00000565813.1

References

  1. Pathways of cellular proteostasis in aging and disease. Klaips CL, Jayaraj GG, Hartl FU. J Cell Biol. 2018 Jan 2;217(1):51–63. PubMed Europe PMC Scholia
  2. Prefoldin, a jellyfish-like molecular chaperone: functional cooperation with a group II chaperonin and beyond. Sahlan M, Zako T, Yohda M. Biophys Rev. 2018 Apr;10(2):339–45. PubMed Europe PMC Scholia