B cell receptor signaling pathway (WP274)

Mus musculus

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The B cell receptor includes membrane and heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_12

For a description of pathway objects, see the WikiPathways Legend.

Authors

Akhilesh Pandey , Alex Pico , Christine Chichester , Martina Summer-Kutmon , Lauren J. Dupuis , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

B cell receptor signaling pathway

Participants

Label Type Compact URI Comment
Elk1 GeneProduct ncbigene:13712
Hdac5 GeneProduct ncbigene:15184
Nfatc3 GeneProduct ncbigene:18021
Grb2 GeneProduct ncbigene:14784
Ccnd2 GeneProduct ncbigene:12444
Mapk1 GeneProduct ncbigene:26413
Ppp3r1 GeneProduct ncbigene:19058
Atf2 GeneProduct ncbigene:11909
Sla2 GeneProduct ncbigene:77799
Pip5k1b GeneProduct ncbigene:18719
Arpc2 GeneProduct ncbigene:76709
Cd22 GeneProduct ncbigene:12483
Gab2 GeneProduct ncbigene:14389
Rela GeneProduct ncbigene:19697
Bcl10 GeneProduct ncbigene:12042
Rasa1 GeneProduct ncbigene:218397
Vav1 GeneProduct ncbigene:22324
Rapgef1 GeneProduct ncbigene:107746
Pdk2 GeneProduct ncbigene:18604
RPS6KB1 GeneProduct ncbigene:72508
Pik3ap1 GeneProduct ncbigene:83490
Dok1 GeneProduct ncbigene:13448
Pip4k2a GeneProduct ncbigene:18718
Prkd1 GeneProduct ncbigene:18760
Gab1 GeneProduct ncbigene:14388
Arpc4 GeneProduct ncbigene:68089
Lat2 GeneProduct ncbigene:56743
Nfatc2 GeneProduct ncbigene:18019
Hdac7 GeneProduct ncbigene:56233
Stat1 GeneProduct ncbigene:20846
Ptprc GeneProduct ncbigene:19264
Casp9 GeneProduct ncbigene:12371
Itpr2 GeneProduct ncbigene:16439
Cdk7 GeneProduct ncbigene:12572
Cdk6 GeneProduct ncbigene:12571
Hck GeneProduct ncbigene:15162
Pik3cg GeneProduct ncbigene:30955
Lcp2 GeneProduct ncbigene:16822
Raf1 GeneProduct ncbigene:110157
Fyn GeneProduct ncbigene:14360
Arpc1b GeneProduct ncbigene:11867
Dapp1 GeneProduct ncbigene:26377
Plcg1 GeneProduct ncbigene:18803
Mapkapk2 GeneProduct ncbigene:17164
Rb1 GeneProduct ncbigene:19645
Actr2 GeneProduct ncbigene:66713
Stat3 GeneProduct ncbigene:20848
Casp7 GeneProduct ncbigene:12369
Cd79a GeneProduct ncbigene:12518
Zap70 GeneProduct ncbigene:22637
Creb1 GeneProduct ncbigene:12912
Cblb GeneProduct ncbigene:208650
Hcls1 GeneProduct ncbigene:15163
Map2k1 GeneProduct ncbigene:26395
Ptpn11 GeneProduct ncbigene:19247
Ikbkg GeneProduct ncbigene:16151
Rps6ka1 GeneProduct ncbigene:20111
Pip4k2c GeneProduct ncbigene:117150
Pik3r2 GeneProduct ncbigene:18709
Cmtm3 GeneProduct ncbigene:68119
Rap2a GeneProduct ncbigene:76108
Prkcd GeneProduct ncbigene:18753
Bcl6 GeneProduct ncbigene:12053
Inpp5d GeneProduct ncbigene:16331
Syk GeneProduct ncbigene:20963
Cd19 GeneProduct ncbigene:12478
Ikbkb GeneProduct ncbigene:16150
Ctnnb1 GeneProduct ncbigene:12387
Braf GeneProduct ncbigene:109880
Ptk2 GeneProduct ncbigene:14083
Bank1 GeneProduct ncbigene:242248
Btk GeneProduct ncbigene:12229
Rel GeneProduct ncbigene:19696
Foxo1 GeneProduct ncbigene:56458
Dok3 GeneProduct ncbigene:27261
Chst15 GeneProduct ncbigene:77590
Cr2 GeneProduct ncbigene:12902
Bcar1 GeneProduct ncbigene:12927
Crkl GeneProduct ncbigene:12929
Lyn GeneProduct ncbigene:17096
Card11 GeneProduct ncbigene:108723
Cdk4 GeneProduct ncbigene:12567
Itpr1 GeneProduct ncbigene:16438
Prkcb GeneProduct ncbigene:18751
Plekha2 GeneProduct ncbigene:83436
Map4k1 GeneProduct ncbigene:26411
Pip5k1a GeneProduct ncbigene:18720
Akt1 GeneProduct ncbigene:11651
Sos2 GeneProduct ncbigene:20663
Ccnd3 GeneProduct ncbigene:12445
Sh2b2 GeneProduct ncbigene:23921
Nedd9 GeneProduct ncbigene:18003
Atp2b4 GeneProduct ncbigene:381290
Stap1 GeneProduct ncbigene:56792
Pip4k2b GeneProduct ncbigene:108083
Chuk GeneProduct ncbigene:12675
Bcl2l11 GeneProduct ncbigene:12125
Map2k2 GeneProduct ncbigene:26396
Sh3bp2 GeneProduct ncbigene:24055
Cd72 GeneProduct ncbigene:12517
Crk GeneProduct ncbigene:12928
Nfkbia GeneProduct ncbigene:18035
Mapk8 GeneProduct ncbigene:26419
Rasgrp3 GeneProduct ncbigene:240168
Prkce GeneProduct ncbigene:18754
Gm10108 GeneProduct ncbigene:670717
Dusp6 GeneProduct ncbigene:67603
Sos1 GeneProduct ncbigene:20662
Ptpn6 GeneProduct ncbigene:15170
Csk GeneProduct ncbigene:12988
Blk GeneProduct ncbigene:12143
Lck GeneProduct ncbigene:16818
Cdk2 GeneProduct ncbigene:12566
Gtf2i GeneProduct ncbigene:14886
Rhoa GeneProduct ncbigene:11848
Bax GeneProduct ncbigene:12028
Mapk4 GeneProduct ncbigene:225724
Jun GeneProduct ncbigene:16476
Nfatc1 GeneProduct ncbigene:18018
Vav2 GeneProduct ncbigene:22325
Pik3r1 GeneProduct ncbigene:18708
Tec GeneProduct ncbigene:21682
Dusp4 GeneProduct ncbigene:319520
Fcgr2b GeneProduct ncbigene:14130
Actr3 GeneProduct ncbigene:74117
Ptk2b GeneProduct ncbigene:19229
Plcg2 GeneProduct ncbigene:234779
Prkcq GeneProduct ncbigene:18761
Cd81 GeneProduct ncbigene:12520
Plekha1 GeneProduct ncbigene:101476
Nck1 GeneProduct ncbigene:17973
Gsk3a GeneProduct ncbigene:606496
Itk GeneProduct ncbigene:16428
Pdpk1 GeneProduct ncbigene:18607
Was GeneProduct ncbigene:22376
Gsk3b GeneProduct ncbigene:56637
Hnrnpk GeneProduct ncbigene:15387
Cbl GeneProduct ncbigene:12402
Map3k7 GeneProduct ncbigene:26409
Ptpn18 GeneProduct ncbigene:19253
Cd5 GeneProduct ncbigene:12507
RPS6 GeneProduct ncbigene:20104
Bcl2 GeneProduct ncbigene:12043
Shc1 GeneProduct ncbigene:20416
Lime1 GeneProduct ncbigene:72699
Mapk3 GeneProduct ncbigene:26417
Ccna2 GeneProduct ncbigene:12428
Arpc3 GeneProduct ncbigene:56378
Cd79b GeneProduct ncbigene:15985
Ppp3ca GeneProduct ncbigene:19055
Arpc5 GeneProduct ncbigene:67771
Blnk GeneProduct ncbigene:17060
Mapk14 GeneProduct ncbigene:26416
Ccne1 GeneProduct ncbigene:12447
Ppp3cb GeneProduct ncbigene:19056
Pip5k1c GeneProduct ncbigene:18717

References