Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids (WP5192)

Homo sapiens

Modulation of the PI3K-Akt-mTOR signaling by bioactive sphinoglipids


Jesper , Anna Van Wersch , Denise Slenter , and Eric Weitz


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Homo sapiens



Disease Ontology

senile degeneration of brain


Label Type Compact URI Comment
ROS Metabolite chebi:26523
Inhibitor of NF-kB kinase Metabolite chebi:77113
Sphingosine 1-phosphate Metabolite hmdb:HMDB0000277
ROS Metabolite chebi:26523
Ceramide 1-phosphates Metabolite chebi:16197
Amino acids Metabolite chebi:33704
RNS Metabolite chebi:62764
Sphingosine Metabolite chebi:45719
Ceramide Metabolite chebi:52639
arginine Metabolite chebi:29016
glucose Metabolite chebi:17234
ROS Metabolite chebi:26523
RNS Metabolite chebi:62764
Ceramide Metabolite chebi:52639
AKT1 GeneProduct ensembl:ENSG00000142208
Hypoxia-inducible factor-1 alpha GeneProduct ensembl:ENSG00000100644
NF-kB GeneProduct ensembl:ENSG00000109320
PI3K Protein ensembl:ENSG00000121879
Ceramide synthase 1 Protein ensembl:ENSG00000223802
Neutral ceramidase Protein uniprot:Q9NR71
Sphingosine 1-phosphate receptor 1 Protein ensembl:ENSG00000170989
Phospholipase D1 Protein ensembl:ENSG00000075651
mTORC1 Protein ensembl:ENSG00000198793
Insulin-like growth factor 1 receptor Protein ensembl:ENSG00000140443
Ceramide kinase Protein uniprot:Q8TCT0
Tuberous sclerosis protein Protein uniprot:Q92574
Sphingosine 1-phosphate receptor 3 Protein uniprot:Q99500
Sphingosine kinase 2 Protein ensembl:ENSG00000063176


  1. The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration. Jęśko H, Stępień A, Lukiw WJ, Strosznajder RP. Mol Neurobiol. 2019 May;56(5):3501–21. PubMed Europe PMC Scholia