Alzheimer's disease (WP5124)

Homo sapiens

draft

Authors

Kristina Hanspers and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Rare Diseases

Annotations

Pathway Ontology

Alzheimer's disease pathway disease pathway

Disease Ontology

Alzheimer's disease

Participants

Label Type Compact URI Comment
NO Metabolite hmdb:HMDB0003378
Fe2+ Metabolite hmdb:HMDB0000692
Hydrogen peroxide Metabolite hmdb:HMDB0003125
AGEs Metabolite chebi:84123
beta-amyloid protein 40 Metabolite chebi:64646
superoxide Metabolite chebi:18421
IP3 Metabolite hmdb:HMDB0001498
PI3P Metabolite chebi:17283
Cu+ Metabolite hmdb:HMDB0000657
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
ONOO- Metabolite hmdb:HMDB0002179
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
beta-amyloid protein 42 Metabolite chebi:64647
beta-amyloid protein 40 Metabolite chebi:64646
beta-amyloid protein 42 Metabolite chebi:64647
PIP3 Metabolite hmdb:HMDB0004249
beta-amyloid protein 40 Metabolite chebi:64646
beta-amyloid protein 42 Metabolite chebi:64647
Ca2+ Metabolite hmdb:HMDB0000464
Ca2+ Metabolite hmdb:HMDB0000464
beta-amyloid protein 40 Metabolite chebi:64646
beta-amyloid protein 42 Metabolite chebi:64647
Ca2+ Metabolite hmdb:HMDB0000464
beta-amyloid protein 40 Metabolite chebi:64646
beta-amyloid protein 42 Metabolite chebi:64647
IRS2 GeneProduct ensembl:ENSG00000185950
ATG14 GeneProduct ensembl:ENSG00000126775 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
P3 peptide GeneProduct uniprot:P05067
TNFRSF1A GeneProduct ensembl:ENSG00000067182
p50 ATF6 GeneProduct ensembl:ENSG00000118217
NAE1 GeneProduct ensembl:ENSG00000159593
APP GeneProduct ensembl:ENSG00000142192
MAPT GeneProduct ensembl:ENSG00000186868
RTN3 GeneProduct ensembl:ENSG00000133318
APP intracellular domain GeneProduct uniprot:P05067
APBB1 GeneProduct ensembl:ENSG00000166313
GAPDH GeneProduct ensembl:ENSG00000111640
ADAM10 GeneProduct ensembl:ENSG00000137845
BACE1 GeneProduct ensembl:ENSG00000186318
PSENEN GeneProduct ensembl:ENSG00000205155
PSEN1 GeneProduct ensembl:ENSG00000080815
NCSTN GeneProduct ensembl:ENSG00000162736
APH1A GeneProduct ensembl:ENSG00000117362
IDE GeneProduct ensembl:ENSG00000119912
MME GeneProduct ensembl:ENSG00000196549
LPL GeneProduct ensembl:ENSG00000175445
APOE GeneProduct ensembl:ENSG00000130203
LRP1 GeneProduct ensembl:ENSG00000123384
FAS GeneProduct ensembl:ENSG00000026103
TNFRSF1A GeneProduct ensembl:ENSG00000067182
FADD GeneProduct ensembl:ENSG00000168040
CASP8 GeneProduct ensembl:ENSG00000064012
HSD17B10 GeneProduct ensembl:ENSG00000072506
BID GeneProduct ensembl:ENSG00000015475
CYCS GeneProduct ensembl:ENSG00000172115
CALM1 GeneProduct ensembl:ENSG00000198668
BAD GeneProduct ensembl:ENSG00000002330
CALM2 GeneProduct ensembl:ENSG00000143933
CALM3 GeneProduct ensembl:ENSG00000160014
CALML3 GeneProduct ensembl:ENSG00000178363
CALML5 GeneProduct ensembl:ENSG00000178372
PPP3CA GeneProduct ensembl:ENSG00000138814
PPP3CB GeneProduct ensembl:ENSG00000107758
PPP3CC GeneProduct ensembl:ENSG00000120910
PPP3R1 GeneProduct ensembl:ENSG00000221823
PPP3R2 GeneProduct ensembl:ENSG00000188386
ADAM17 GeneProduct ensembl:ENSG00000151694
PSEN2 GeneProduct ensembl:ENSG00000143801
APAF1 GeneProduct ensembl:ENSG00000120868
CASP9 GeneProduct ensembl:ENSG00000132906
CASP3 GeneProduct ensembl:ENSG00000164305
SNCA GeneProduct ensembl:ENSG00000145335
GRIN1 GeneProduct ensembl:ENSG00000176884
CACNA1C GeneProduct ensembl:ENSG00000151067
GRIN2A GeneProduct ensembl:ENSG00000183454
GRIN2B GeneProduct ensembl:ENSG00000273079
GRIN2C GeneProduct ensembl:ENSG00000161509
GRIN2D GeneProduct ensembl:ENSG00000105464
CACNA1D GeneProduct ensembl:ENSG00000157388
CACNA1F GeneProduct ensembl:ENSG00000102001
CACNA1S GeneProduct ensembl:ENSG00000081248
GNAQ GeneProduct ensembl:ENSG00000156052
PLCB1 GeneProduct ensembl:ENSG00000182621
PLCB2 GeneProduct ensembl:ENSG00000137841
PLCB3 GeneProduct ensembl:ENSG00000149782
PLCB4 GeneProduct ensembl:ENSG00000101333
TNF GeneProduct ensembl:ENSG00000232810
IL1B GeneProduct ensembl:ENSG00000125538
MAPK1 GeneProduct ensembl:ENSG00000100030
MAPK3 GeneProduct ensembl:ENSG00000102882
CASP12 GeneProduct ensembl:ENSG00000204403
RYR3 GeneProduct ensembl:ENSG00000198838
ATP2A2 GeneProduct ensembl:ENSG00000174437
ATP2A1 GeneProduct ensembl:ENSG00000196296
ATP2A3 GeneProduct ensembl:ENSG00000074370
EIF2AK3 GeneProduct ensembl:ENSG00000172071
ERN1 GeneProduct ensembl:ENSG00000178607
ATF6 GeneProduct ensembl:ENSG00000118217
ITPR1 GeneProduct ensembl:ENSG00000150995
ITPR2 GeneProduct ensembl:ENSG00000123104
ITPR3 GeneProduct ensembl:ENSG00000096433
CAPN1 GeneProduct ensembl:ENSG00000014216
CAPN2 GeneProduct ensembl:ENSG00000162909
CDK5R1 / p35 GeneProduct ensembl:ENSG00000176749
CDK5R1 / p25 GeneProduct ensembl:ENSG00000176749
NOS1 GeneProduct ensembl:ENSG00000089250
CDK5 GeneProduct ensembl:ENSG00000164885
MAPT GeneProduct ensembl:ENSG00000186868
CASP3 GeneProduct ensembl:ENSG00000164305
CASP7 GeneProduct ensembl:ENSG00000165806
RTN4 GeneProduct ensembl:ENSG00000115310
INS GeneProduct ncbigene:3630
INSR GeneProduct ensembl:ENSG00000171105
IRS1 GeneProduct ensembl:ENSG00000169047
IRS4 GeneProduct ensembl:ENSG00000133124
PPID GeneProduct ensembl:ENSG00000171497
MCU GeneProduct ensembl:ENSG00000156026
AKT1 GeneProduct ensembl:ENSG00000142208
AKT2 GeneProduct ensembl:ENSG00000105221
AKT3 GeneProduct ensembl:ENSG00000117020
PIK3CA GeneProduct ensembl:ENSG00000121879 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3R1 GeneProduct ensembl:ENSG00000145675 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2 GeneProduct ensembl:ENSG00000105647 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3CB GeneProduct ensembl:ENSG00000051382 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CD GeneProduct ensembl:ENSG00000171608 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3R3 GeneProduct ensembl:ENSG00000117461 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
EIF2AK2 GeneProduct ensembl:ENSG00000055332
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK9 GeneProduct ensembl:ENSG00000050748
MAPK10 GeneProduct ensembl:ENSG00000109339
GPR83 GeneProduct ensembl:ENSG00000123901
CHUK GeneProduct ensembl:ENSG00000213341
IKBKB GeneProduct ensembl:ENSG00000104365
CHRNA7 GeneProduct ensembl:ENSG00000175344
CYBB GeneProduct ensembl:ENSG00000165168
NOX1 GeneProduct ensembl:ENSG00000007952
NOX4 GeneProduct ensembl:ENSG00000086991
NFKB1 GeneProduct ensembl:ENSG00000109320
RELA GeneProduct ncbigene:5970
NRAS GeneProduct ensembl:ENSG00000213281 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176
KRAS GeneProduct ensembl:ENSG00000133703 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
HRAS GeneProduct ensembl:ENSG00000174775 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
RAF1 GeneProduct ensembl:ENSG00000132155 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
ARAF GeneProduct ensembl:ENSG00000078061 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
BRAF GeneProduct ensembl:ENSG00000157764 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
NOS2 GeneProduct ensembl:ENSG00000007171
TNF GeneProduct ensembl:ENSG00000232810
IL1A GeneProduct ensembl:ENSG00000115008
IL1B GeneProduct ensembl:ENSG00000125538
PTGS2 GeneProduct ensembl:ENSG00000073756
IL6 GeneProduct ensembl:ENSG00000136244
CSF1 GeneProduct ensembl:ENSG00000184371
DKK1 GeneProduct ensembl:ENSG00000107984 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK2 GeneProduct ensembl:ENSG00000155011 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK4 GeneProduct ensembl:ENSG00000104371 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
MTOR GeneProduct ensembl:ENSG00000198793 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ULK2 GeneProduct ensembl:ENSG00000083290 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ULK1 GeneProduct ensembl:ENSG00000177169 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG13 GeneProduct ensembl:ENSG00000175224 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG101 GeneProduct ensembl:ENSG00000123395 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
RB1CC1 GeneProduct ensembl:ENSG00000023287 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BECN1 GeneProduct ensembl:ENSG00000126581 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BECN2 GeneProduct ensembl:ENSG00000196289 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
PIK3R4 GeneProduct ensembl:ENSG00000196455 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
NRBF2 GeneProduct ensembl:ENSG00000148572 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
PIK3C3 GeneProduct ensembl:ENSG00000078142 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
AMBRA1 GeneProduct ensembl:ENSG00000110497 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2A GeneProduct ensembl:ENSG00000110046 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2B GeneProduct ensembl:ENSG00000066739 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
WIPI1 GeneProduct ensembl:ENSG00000070540 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
WIPI2 GeneProduct ensembl:ENSG00000157954 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
PSEN1 GeneProduct ensembl:ENSG00000080815 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
GSK3B GeneProduct ensembl:ENSG00000082701 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC3 GeneProduct ensembl:ENSG00000104892 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5A GeneProduct ensembl:ENSG00000155980 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5B GeneProduct ensembl:ENSG00000170759 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5C GeneProduct ensembl:ENSG00000168280 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC1 GeneProduct ensembl:ENSG00000126214 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC2 GeneProduct ensembl:ENSG00000174996 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC4 GeneProduct ensembl:ENSG00000137171 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA1B GeneProduct ensembl:ENSG00000123416 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3E GeneProduct ensembl:ENSG00000152086 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3D GeneProduct ensembl:ENSG00000075886 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA8 GeneProduct ensembl:ENSG00000183785 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA4A GeneProduct ensembl:ENSG00000127824 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3C GeneProduct ensembl:ENSG00000198033 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA1A GeneProduct ensembl:ENSG00000167552 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBAL3 GeneProduct ensembl:ENSG00000178462 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA1C GeneProduct ensembl:ENSG00000167553 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB3 GeneProduct ensembl:ENSG00000258947 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB4A GeneProduct ensembl:ENSG00000104833 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB4B GeneProduct ensembl:ENSG00000188229 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB GeneProduct ensembl:ENSG00000196230 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB8 GeneProduct ensembl:ENSG00000261456 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB2B GeneProduct ensembl:ENSG00000137285 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB2A GeneProduct ensembl:ENSG00000137267 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB1 GeneProduct ensembl:ENSG00000101162 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB6 GeneProduct ensembl:ENSG00000176014 SOS1; son of sevenless homolog 1 (Drosophila)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
WNT3A GeneProduct ncbigene:89780
WNT7A GeneProduct ncbigene:7476
WNT11 GeneProduct ncbigene:7481
WNT1 GeneProduct ncbigene:7471
WNT5B GeneProduct ncbigene:81029
WNT2 GeneProduct ncbigene:7472
WNT2B GeneProduct ncbigene:7482
WNT6 GeneProduct ncbigene:7475
WNT5A GeneProduct ncbigene:7474
WNT16 GeneProduct ncbigene:51384
WNT4 GeneProduct ncbigene:54361
WNT3 GeneProduct ncbigene:7473
WNT10B GeneProduct ncbigene:7480
WNT7B GeneProduct ncbigene:7477
WNT10A GeneProduct ncbigene:80326
WNT16 GeneProduct ncbigene:51384
FZD3 GeneProduct ncbigene:7976
FZD8 GeneProduct ncbigene:8325
LRP5 GeneProduct ncbigene:4041
FZD10 GeneProduct ncbigene:11211
FZD7 GeneProduct ncbigene:8324
FZD4 GeneProduct ncbigene:6424
FZD1 GeneProduct ncbigene:8321
LRP6 GeneProduct ncbigene:4040
FZD6 GeneProduct ncbigene:8323
FZD5 GeneProduct ncbigene:7855
FZD9 GeneProduct ncbigene:8326
FZD2 GeneProduct ncbigene:2535
DVL3 GeneProduct ncbigene:1857
FRAT1 GeneProduct ncbigene:10023
CSNK1E GeneProduct ncbigene:1454
DVL2 GeneProduct ncbigene:1856
DVL1 GeneProduct ncbigene:1855
FRAT2 GeneProduct ensembl:ENSG00000181274
TPTEP2-CSNK1E GeneProduct ncbigene:1454
GSK3B GeneProduct ncbigene:2932 MOUSE:KG38 MOUSE
CSNK2B GeneProduct ensembl:ENSG00000204435
CSNK2A1 GeneProduct ensembl:ENSG00000101266
CSNK2A3 GeneProduct ensembl:ENSG00000254598
CSNK2A2 GeneProduct ensembl:ENSG00000070770
APC GeneProduct ncbigene:324
CSNK1A1 GeneProduct ensembl:ENSG00000113712
AXIN1 GeneProduct ncbigene:8312
CSNK1A1L GeneProduct ensembl:ENSG00000180138
AXIN2 GeneProduct ensembl:ENSG00000168646
APC2 GeneProduct ensembl:ENSG00000115266
CSNK1A1 GeneProduct ensembl:ENSG00000113712
CSNK1A1L GeneProduct ensembl:ENSG00000180138
CTNNB1 GeneProduct ncbigene:1499
PPP3CA GeneProduct ensembl:ENSG00000138814
PPP3CB GeneProduct ensembl:ENSG00000107758
PPP3CC GeneProduct ensembl:ENSG00000120910
PPP3R1 GeneProduct ensembl:ENSG00000221823
PPP3R2 GeneProduct ensembl:ENSG00000188386
GSK3B GeneProduct ncbigene:2932 MOUSE:KG38 MOUSE
sAPP alpha GeneProduct uniprot:P05067
APP-C83 GeneProduct uniprot:P05067
APP-C99 GeneProduct uniprot:P05067
sAPP beta GeneProduct uniprot:P05067
EIF2S1 GeneProduct ensembl:ENSG00000134001
ATF4 GeneProduct ensembl:ENSG00000128272
DDIT3 GeneProduct ensembl:ENSG00000175197
TRAF2 GeneProduct ensembl:ENSG00000127191
MAP3K5 GeneProduct ensembl:ENSG00000197442
MAP2K7 GeneProduct ensembl:ENSG00000076984
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK10 GeneProduct ensembl:ENSG00000109339
MAPK9 GeneProduct ensembl:ENSG00000050748
XBP1 GeneProduct ensembl:ENSG00000100219
DDIT3 GeneProduct ensembl:ENSG00000175197
XBP1 GeneProduct ensembl:ENSG00000100219
PSMA2 GeneProduct ncbigene:5683
PSMB1 GeneProduct ncbigene:5689
PSMA5 GeneProduct ncbigene:5686
PSMB4 GeneProduct ncbigene:5692
PSMB2 GeneProduct ncbigene:5690
PSMA3 GeneProduct ncbigene:5684
PSMA7 GeneProduct ncbigene:5688
PSMA1 GeneProduct ncbigene:5682
PSMB6 GeneProduct ncbigene:5694 U13393
PSMA6 GeneProduct ncbigene:5687
PSMB5 GeneProduct ncbigene:5693
PSMA4 GeneProduct ncbigene:5685
PSMB7 GeneProduct ncbigene:5695
PSMB3 GeneProduct ncbigene:5691
PSMA8 GeneProduct ensembl:ENSG00000154611
PSMD8 GeneProduct ncbigene:5714
SEM1 GeneProduct ensembl:ENSG00000127922
PSMD1 GeneProduct ncbigene:5707
PSMC6 GeneProduct ncbigene:5706
PSMC5 GeneProduct ncbigene:5705
PSMC4 GeneProduct ncbigene:5704
PSMC3 GeneProduct ncbigene:5702
PSMC2 GeneProduct ncbigene:5701
PSMC1 GeneProduct ncbigene:5700
PSMD7 GeneProduct ncbigene:5713
PSMD6 GeneProduct ncbigene:9861
ADRM1 GeneProduct ensembl:ENSG00000130706
PSMD4 GeneProduct ncbigene:5710
PSMD3 GeneProduct ncbigene:5709
PSMD2 GeneProduct ncbigene:5708
PSMD14 GeneProduct ncbigene:10213
PSMD13 GeneProduct ncbigene:5719
PSMD12 GeneProduct ncbigene:5718
PSMD9 GeneProduct ncbigene:5715
PPIF GeneProduct ensembl:ENSG00000108179
SLC25A4 GeneProduct ensembl:ENSG00000151729
SLC25A5 GeneProduct ensembl:ENSG00000005022
SLC25A6 GeneProduct ensembl:ENSG00000169100
VDAC1 GeneProduct ensembl:ENSG00000213585
VDAC2 GeneProduct ensembl:ENSG00000165637
VDAC3 GeneProduct ensembl:ENSG00000078668
SLC25A31 GeneProduct ensembl:ENSG00000151475
CALML4 GeneProduct ensembl:ENSG00000129007
CALML6 GeneProduct ensembl:ENSG00000169885
APH1B GeneProduct ensembl:ENSG00000138613
MAP2K1 GeneProduct ncbigene:5604
MAP2K2 GeneProduct ncbigene:5605
MAPK1 GeneProduct ncbigene:5594
MAPK3 GeneProduct ncbigene:5595
PSEN1 GeneProduct ensembl:ENSG00000080815
PSEN2 GeneProduct ensembl:ENSG00000143801
RAGE Protein uniprot:Q15109
NAC fragment Protein uniprot:P37840

References

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  2. Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Ivins KJ, Thornton PL, Rohn TT, Cotman CW. Neurobiol Dis. 1999 Oct;6(5):440–9. PubMed Europe PMC Scholia
  3. Neurotoxicity induces cleavage of p35 to p25 by calpain. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. Nature. 2000 May 18;405(6784):360–4. PubMed Europe PMC Scholia
  4. Alzheimer’s disease and Abeta toxicity: from top to bottom. Small DH, Mok SS, Bornstein JC. Nat Rev Neurosci. 2001 Aug;2(8):595–8. PubMed Europe PMC Scholia
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  10. The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. Gandy S. J Clin Invest. 2005 May;115(5):1121–9. PubMed Europe PMC Scholia
  11. Tau phosphorylation and aggregation in Alzheimer’s disease pathology. Avila J. FEBS Lett. 2006 May 22;580(12):2922–7. PubMed Europe PMC Scholia
  12. Mitochondrial dysfunction in sporadic and genetic Alzheimer’s disease. Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE. Exp Gerontol. 2006 Jul;41(7):668–73. PubMed Europe PMC Scholia
  13. Distinct destructive signal pathways of neuronal death in Alzheimer’s disease. Shen Y, He P, Zhong Z, McAllister C, Lindholm K. Trends Mol Med. 2006 Dec;12(12):574–9. PubMed Europe PMC Scholia
  14. Presenilin-mediated signal transduction. Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A. Physiol Behav. 2007 Sep 10;92(1–2):93–7. PubMed Europe PMC Scholia
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