Wnt myofibroblastic activation of hepatic stellate cells (WP3649)
This pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases MeCP2 stability and induces epigenetic repression of Ppar-y leading to hepatic stellate cell myofibroblastic activation causing liver fibrosis which can lead to liver cirrhosis.
AuthorsAAR&Co , Egon Willighagen , Marianthi Kalafati , Kristina Hanspers , and Eric Weitz
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- Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air (2020).
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Pathway Ontologysignaling pathway
Cell Type Ontologyhepatic stellate cell
Disease Ontologyliver cirrhosis
- Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. PLoS One. 2016 May 23;11(5):e0156111. PubMed Europe PMC Scholia