Wnt myofibroblastic activation of hepatic stellate cells (WP3649)

Rattus norvegicus

This pathway is modeled after figure 5 from Kweon et al. The WNT signaling pathway activates Beta-catenin which inhibits serine and cysteine proteases. This inhibition of these proteins increases MeCP2 stability and induces epigenetic repression of Ppar-y leading to hepatic stellate cell myofibroblastic activation causing liver fibrosis which can lead to liver cirrhosis.

Authors

AAR&Co , Egon Willighagen , Marianthi Kalafati , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

signaling pathway

Cell Type Ontology

hepatic stellate cell

Disease Ontology

liver cirrhosis

Participants

Label Type Compact URI Comment
DPI Metabolite pubchem.compound:3101
Leupeptin Metabolite pubchem.compound:72429
Beta-Catenin GeneProduct ncbigene:84353
Wnt-3a Protein ensembl:ENSRNOT00000064505
MeCP2 Protein ensembl:ENSRNOG00000056659
Ppar-y Protein ensembl:ENSRNOG00000008839

References

  1. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. PLoS One. 2016 May 23;11(5):e0156111. PubMed Europe PMC Scholia