Fatty acids and lipoproteins transport in hepatocytes (WP5323)

Homo sapiens

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This model was constructed integrating the Fatty acid transporters (Homo sapiens) metapathway (WP5061), the Cholesterol metabolism (Homo sapiens) (WP5304) and the KEGG Cholesterol metabolism pathway (map04979) as well as information from the literature.

Authors

Luiz C. M. Ladeira , Martina Summer-Kutmon , Egon Willighagen , Denise Slenter , Javier Millán Acosta , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

hepatocyte centrilobular region hepatocyte

Participants
Query Drugst.One

Label Type Compact URI Comment
Long-chain Fatty Acids Metabolite chebi:15904
Long-chain Fatty Acids Metabolite chebi:15904
Long-chain Fatty Acids Metabolite chebi:15904
Long-chain Fatty Acids Metabolite chebi:15904
Long-chain Fatty Acids Metabolite chebi:15904
Fatty acyl-CoA Metabolite chebi:37554
Fatty acyl-CoA Metabolite chebi:37554
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Cholesterol ester Metabolite chebi:17002
Triacylglycerol Metabolite chebi:17855
Triacylglycerol Metabolite chebi:17855
Triacylglycerol Metabolite chebi:17855
Triacylglycerol Metabolite chebi:17855
Triacylglycerol Metabolite chebi:17855
Triacylglycerol Metabolite chebi:17855
Triacylglycerol Metabolite chebi:17855
Phospholipids Metabolite chebi:16247
Phospholipids Metabolite chebi:16247
Phospholipids Metabolite chebi:16247
Phospholipids Metabolite chebi:16247
Phospholipids Metabolite chebi:16247
Cholesterol Metabolite chebi:16113
Cholesterol Metabolite chebi:16113
Cholesterol Metabolite chebi:16113
Cholesterol Metabolite chebi:16113
Cholesterol Metabolite chebi:16113
CoA Metabolite chebi:15346
CD36 Protein hgnc:1663
CD36 Protein hgnc:1663
APOB Protein ncbigene:338
APOE Protein ensembl:ENSG00000130203
APOE Protein ensembl:ENSG00000130203
APOC1 Protein refseq:NM_001321065
APOE Protein ensembl:ENSG00000130203
APOE Protein ensembl:ENSG00000130203
APOA1 Protein hgnc:600
APOA2 Protein hgnc:601
APOC1 Protein refseq:NM_001321065
APOB Protein ncbigene:338
APOE Protein ensembl:ENSG00000130203
APOE Protein ensembl:ENSG00000130203
LRPAP1 Protein hgnc:6701
LRP1 Protein refseq:NM_002332
LDLRAP1 Protein ensembl:ENSG00000157978
SORT1 Protein ncbigene:6272
MYLIP Protein refseq:NM_013262
APOB Protein ncbigene:338
LDLR Protein hgnc.symbol:LDLR
PCSK9 Protein uniprot:Q8NBP7
LDLR Protein hgnc.symbol:LDLR
PCSK9 Protein uniprot:Q8NBP7
DBI Protein hgnc.symbol:DBI ACBP acyl-CoA binding protein Approved symbol: DBI Previous names: diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2690
FABP2 Protein refseq:NM_000134
LIPA Protein hgnc.symbol:LIPA
STARD3 Protein uniprot:Q14849
VAPA Protein hgnc:12648
NPC1 Protein hgnc:7897
OSBPL5 Protein ensembl:ENSG00000021762
NPC2 Protein ensembl:ENSG00000119655
STARD3 Protein uniprot:Q14849
VDAC1 Protein ensembl:ENSG00000213585
VDAC1 Protein ensembl:ENSG00000213585
STAR Protein hgnc.symbol:STAR
TSPO Protein hgnc:1158
LDLR Protein hgnc.symbol:LDLR
PCSK9 Protein uniprot:Q8NBP7
SOAT1 Protein hgnc.symbol:SOAT1
SOAT2 Protein refseq:NM_003578
SORT1 Protein ncbigene:6272
APOB Protein ncbigene:338
LCAT Protein hgnc:6522
SCARB1 Protein uniprot:Q8WTV0
APOB Protein ncbigene:338
LDLR Protein hgnc.symbol:LDLR
APOB Protein ncbigene:338
APOE Protein ensembl:ENSG00000130203
ACSL1 Protein ncbigene:2180
ACSL3 Protein refseq:NM_004457
ACSL4 Protein hgnc:3571
ACSL5 Protein ensembl:ENSG00000197142
ACSL6 Protein ensembl:ENSG00000164398
SLC27A2 Protein ncbigene:11001
SLC27A4 Protein ensembl:ENSG00000167114
SLC27A5 Protein hgnc:10999
SLC27A1 Protein ncbigene:376497
SLC27A3 Protein refseq:NM_024330
FABP3 Protein ensembl:ENSG00000121769
FABP5 Protein hgnc:3560
FABP1 Protein refseq:NM_001443
FABP4 Protein refseq:NM_001442
ABCA1 Protein refseq:NM_005502
SORT1 Protein ncbigene:6272
APOA1 Protein hgnc:600
APOA2 Protein hgnc:601
APOA1 Protein hgnc:600
MTTP Protein hgnc:7467
APOA4 Protein hgnc.symbol:APOA4
APOB Protein ncbigene:338
APOC1 Protein refseq:NM_001321065
DBI Protein hgnc.symbol:DBI
APOA1 Protein hgnc:600
LPA Protein ensembl:ENSG00000198670
APOB Protein ncbigene:338
APOC1 Protein refseq:NM_001321065
APOA2 Protein hgnc:601
APOC2 Protein uniprot:P02655
APOC3 Protein hgnc:610
APOB Protein ncbigene:338
APOB Protein ncbigene:338

References

  1. A current review of fatty acid transport proteins (SLC27). Stahl A. Pflugers Arch. 2004 Feb;447(5):722–7. PubMed Europe PMC Scholia
  2. Liver lipid metabolism. Nguyen P, Leray V, Diez M, Serisier S, Le Bloc’h J, Siliart B, et al. J Anim Physiol Anim Nutr (Berl). 2008 Jun;92(3):272–83. PubMed Europe PMC Scholia