Regulation of cardiac hypertrophy by miR-208 (WP1526)

Mus musculus

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
MicroRNA-208a regulates cardiac hypertrophy pathways in mice. MicroRNAs are shown in purple. Knock out and overexpression of miR-208a are shown in blue. Processes are shown at the top and include hypertrophy, atrial fibrilation and prolonged PR interval & abberand conduction.

Authors

Maartje Levels , Susan Coort , Martina Summer-Kutmon , Kristina Hanspers , Linda Rieswijk , Eric Weitz , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

hypertrophic cardiomyopathy pathway

Participants

Label Type Compact URI Comment
Gata4 GeneProduct ncbigene:14463
beta-MHC GeneProduct ncbigene:140781
Hop GeneProduct ncbigene:74318
Trap1 Protein ncbigene:327987
Cx40 Protein ncbigene:14613
Myostatin Protein ncbigene:17700

References

  1. Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice. Lo CW. Circ Res. 2000 Sep 1;87(5):346–8. PubMed Europe PMC Scholia
  2. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, et al. J Clin Invest. 2009 Sep;119(9):2772–86. PubMed Europe PMC Scholia