Regulation of cardiac hypertrophy by miR-208 (WP1526)
Mus musculus
MicroRNA-208a regulates cardiac hypertrophy pathways in mice. MicroRNAs are shown in purple. Knock out and overexpression of miR-208a are shown in blue. Processes are shown at the top and include hypertrophy, atrial fibrilation and prolonged PR interval & abberand conduction.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Maartje Levels , Susan Coort , Martina Summer-Kutmon , Kristina Hanspers , Linda Rieswijk , Eric Weitz , and Egon WillighagenActivity
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Cited In
- Reprogramming of glucocorticoid receptor function by hypoxia (2021).
- Transcriptome analysis in cardiomyocyte-specific differentiation of murine embryonic stem cells reveals transcriptional regulation network (2014).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
hypertrophic cardiomyopathy pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Gata4 | GeneProduct | ncbigene:14463 | |
| beta-MHC | GeneProduct | ncbigene:140781 | |
| Hop | GeneProduct | ncbigene:74318 | |
| Trap1 | Protein | ncbigene:327987 | |
| Cx40 | Protein | ncbigene:14613 | |
| Myostatin | Protein | ncbigene:17700 |
References
- Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice. Lo CW. Circ Res. 2000 Sep 1;87(5):346–8. PubMed Europe PMC Scholia
- MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, et al. J Clin Invest. 2009 Sep;119(9):2772–86. PubMed Europe PMC Scholia