GPCRs, class A rhodopsin-like (WP455)

Homo sapiens

This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Nathan Salomonis , Alex Pico , Bruce Conklin , Kristina Hanspers , Egon Willighagen , Zahra Roudbari , and Eric Weitz


last edited

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Homo sapiens



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Opioid Metabolite chebi:60598
Somatostatin Metabolite chebi:64628
Dopamine Metabolite cas:62-31-7
Bradykinin Metabolite cas:58-82-2
Prostaglandin Metabolite cas:745-65-3
Melatonin Metabolite hmdb:HMDB0001389
Serotonin Metabolite cas:50-67-9
Angiotensin II Metabolite hmdb:HMDB0001035
Histamine Metabolite cas:51-45-6
GPR32 GeneProduct ncbigene:2854
OR1E2 GeneProduct ncbigene:8388
RRH GeneProduct ncbigene:10692
XCR1 GeneProduct ncbigene:2829
OR3A3 GeneProduct ncbigene:8392
CCR4 GeneProduct ncbigene:1233
OR10H3 GeneProduct ncbigene:26532
DRD2 GeneProduct ncbigene:1813
GPR52 GeneProduct ncbigene:9293
MC1R GeneProduct ncbigene:4157
P2RY10 GeneProduct ncbigene:27334
OPRM1 GeneProduct ncbigene:4988
F2RL1 GeneProduct ncbigene:2150
P2RY4 GeneProduct ncbigene:5030
HTR2B GeneProduct ncbigene:3357
CYSLTR2 GeneProduct ncbigene:57105
MTNR1B GeneProduct ncbigene:4544
HTR1F GeneProduct ncbigene:3355
NPY6R GeneProduct ncbigene:4888
OR7C1 GeneProduct ncbigene:26664
OR5V1 GeneProduct ncbigene:81696
MAS1L GeneProduct ncbigene:116511
CNR1 GeneProduct ncbigene:1268
GPR85 GeneProduct ncbigene:54329
BLR1 GeneProduct ncbigene:643
CCRL1 GeneProduct ncbigene:51554
GPR17 GeneProduct ncbigene:2840
GPR42 GeneProduct ncbigene:2866
P2RY6 GeneProduct ncbigene:5031
GPR8 GeneProduct ncbigene:2832
GALR2 GeneProduct ncbigene:8811
SSTR5 GeneProduct ncbigene:6755
OR7C2 GeneProduct ncbigene:26658
NTSR2 GeneProduct ncbigene:23620
CX3CR1 GeneProduct ncbigene:1524
GPR15 GeneProduct ncbigene:2838
GPR37L1 GeneProduct ncbigene:9283
OR12D3 GeneProduct ncbigene:81797
SSTR4 GeneProduct ncbigene:6754
GPR6 GeneProduct ncbigene:2830
OR8B8 GeneProduct ncbigene:26493
P2RY2 GeneProduct ncbigene:5029
GPR92 GeneProduct ncbigene:57121
GPR39 GeneProduct ncbigene:2863
SSTR2 GeneProduct ncbigene:6752
DRD4 GeneProduct ncbigene:1815
OR7A17 GeneProduct ncbigene:26333
CCR8 GeneProduct ncbigene:1237
CHRM2 GeneProduct ncbigene:1129
HCRTR1 GeneProduct ncbigene:3061
OPRL1 GeneProduct ncbigene:4987
CXCR3 GeneProduct ncbigene:2833
MTNR1A GeneProduct ncbigene:4543
OPN1MW GeneProduct ncbigene:2652
FPR1 GeneProduct ncbigene:2357
OPRK1 GeneProduct ncbigene:4986
F2RL3 GeneProduct ncbigene:9002
PTGER1 GeneProduct ncbigene:5731
PTGER4 GeneProduct ncbigene:5734
Rgr GeneProduct ncbigene:266747
PTGFR GeneProduct ncbigene:5737
OR2S2 GeneProduct ncbigene:56656
OR2J2 GeneProduct ncbigene:26707
CNR2 GeneProduct ncbigene:1269
ADRA2A GeneProduct ncbigene:150
MLNR GeneProduct ncbigene:2862
HTR4 GeneProduct ncbigene:3360
OR1G1 GeneProduct ncbigene:8390
OR10A4 GeneProduct ncbigene:283297
ADORA1 GeneProduct ncbigene:134
NMBR GeneProduct ncbigene:4829
NMUR2 GeneProduct ncbigene:56923
TRHR GeneProduct ncbigene:7201
OPN4 GeneProduct ncbigene:94233
HTR1B GeneProduct ncbigene:3351
GPR19 GeneProduct ncbigene:2842
GPR22 GeneProduct ncbigene:2845
RHO GeneProduct ncbigene:6010
F2R GeneProduct ncbigene:2149
ADORA2A GeneProduct ncbigene:135
FPRL1 GeneProduct ncbigene:2358
OR7A10 GeneProduct ncbigene:390892
SSTR1 GeneProduct ncbigene:6751
CMKLR1 GeneProduct ncbigene:1240
NMUR1 GeneProduct ncbigene:10316
ADRA2C GeneProduct ncbigene:152
ADORA3 GeneProduct ncbigene:140
GPR31 GeneProduct ncbigene:2853
GPR41 GeneProduct ncbigene:2865
GPR24 GeneProduct ncbigene:2847
GPR161 GeneProduct ncbigene:23432
PTAFR GeneProduct ncbigene:5724
OR2B6 GeneProduct ncbigene:26212
GALR1 GeneProduct ncbigene:2587
AGTR1 GeneProduct ncbigene:185
CHRM4 GeneProduct ncbigene:1132
OR2W1 GeneProduct ncbigene:26692
OR2B3 GeneProduct ncbigene:442184
PTGER2 GeneProduct ncbigene:5732
OR2H2 GeneProduct ncbigene:7932
OXTR GeneProduct ncbigene:5021
OR5F1 GeneProduct ncbigene:338674
HCRTR2 GeneProduct ncbigene:3062
GPR37 GeneProduct ncbigene:2861
GPR173 GeneProduct ncbigene:54328
ADRA1B GeneProduct ncbigene:147
GPR34 GeneProduct ncbigene:2857
GPR50 GeneProduct ncbigene:9248
OR1D2 GeneProduct ncbigene:4991
OR1F1 GeneProduct ncbigene:4992
LHCGR GeneProduct ncbigene:3973
OR1D5 GeneProduct ncbigene:8386
P2RY1 GeneProduct ncbigene:5028
HTR5A GeneProduct ncbigene:3361
OR10A5 GeneProduct ncbigene:144124
ADRB1 GeneProduct ncbigene:153
GPR68 GeneProduct ncbigene:8111
HTR6 GeneProduct ncbigene:3362
PTGER3 GeneProduct ncbigene:5733
LTB4R GeneProduct ncbigene:1241
NPY1R GeneProduct ncbigene:4886
OR6A2 GeneProduct ncbigene:8590
OR1C1 GeneProduct ncbigene:26188
GPR65 GeneProduct ncbigene:8477
GPR35 GeneProduct ncbigene:2859
GPR1 GeneProduct ncbigene:2825
P2RY13 GeneProduct ncbigene:53829
OR5U1 GeneProduct ncbigene:442191
CCR3 GeneProduct ncbigene:1232
GPR109B GeneProduct ncbigene:8843
HTR1E GeneProduct ncbigene:3354
GRPR GeneProduct ncbigene:2925
HTR1A GeneProduct ncbigene:3350
OR2F2 GeneProduct ncbigene:135948
IL8RB GeneProduct ncbigene:3579
OR2B2 GeneProduct ncbigene:81697
GPR174 GeneProduct ncbigene:84636
DRD3 GeneProduct ncbigene:1814
OR10H1 GeneProduct ncbigene:26539
GPR74 GeneProduct ncbigene:10886
OR8D2 GeneProduct ncbigene:283160
GPR63 GeneProduct ncbigene:81491
PTGIR GeneProduct ncbigene:5739
OPN3 GeneProduct ncbigene:23596
GPR7 GeneProduct ncbigene:2831
GPR10 GeneProduct ncbigene:2834
GPR45 GeneProduct ncbigene:11250
CCRL2 GeneProduct ncbigene:9034
OPN1SW GeneProduct ncbigene:611
GPR81 GeneProduct ncbigene:27198
OR3A1 GeneProduct ncbigene:4994
CCR6 GeneProduct ncbigene:1235
FSHR GeneProduct ncbigene:2492
GPR77 GeneProduct ncbigene:27202
AVPR1B GeneProduct ncbigene:553
IL8RA GeneProduct ncbigene:3577
P2RY14 GeneProduct ncbigene:9934
GPR3 GeneProduct ncbigene:2827
OR2A4 GeneProduct ncbigene:79541
OR10J1 GeneProduct ncbigene:26476
FPRL2 GeneProduct ncbigene:2359
OPRD1 GeneProduct ncbigene:4985
OR1A1 GeneProduct ncbigene:8383
HRH3 GeneProduct ncbigene:11255
GPR44 GeneProduct ncbigene:11251
P2RY11 GeneProduct ncbigene:5032
GPR23 GeneProduct ncbigene:2846
ADORA2B GeneProduct ncbigene:136
F2RL2 GeneProduct ncbigene:2151
OR2J3 GeneProduct ncbigene:442186
OR5I1 GeneProduct ncbigene:10798
GPR40 GeneProduct ncbigene:2864
CCBP2 GeneProduct ncbigene:1238
CCKBR GeneProduct ncbigene:887
NPY5R GeneProduct ncbigene:4889
ADRB3 GeneProduct ncbigene:155
OR2D2 GeneProduct ncbigene:120776
ADRA1A GeneProduct ncbigene:148
CMKOR1 GeneProduct ncbigene:57007
GPR43 GeneProduct ncbigene:2867
OR7A5 GeneProduct ncbigene:26659
OR10H2 GeneProduct ncbigene:26538
GPR87 GeneProduct ncbigene:53836
GALR3 GeneProduct ncbigene:8484
OR2J1 GeneProduct ncbigene:442185
OR2N1P GeneProduct ncbigene:26701
HTR2A GeneProduct ncbigene:3356
CHRM3 GeneProduct ncbigene:1131
BRS3 GeneProduct ncbigene:680
EDNRA GeneProduct ncbigene:1909
OR3A2 GeneProduct ncbigene:4995
CCR2 GeneProduct ncbigene:729230
OR2T1 GeneProduct ncbigene:26696
OR1D4 GeneProduct ncbigene:653166
AGTRL1 GeneProduct ncbigene:187
MC2R GeneProduct ncbigene:4158
DRD5 GeneProduct ncbigene:1816
GPR21 GeneProduct ncbigene:2844
P2RY5 GeneProduct ncbigene:10161
TBXA2R GeneProduct ncbigene:6915
ADRB2 GeneProduct ncbigene:154
ADRA1D GeneProduct ncbigene:146
OR1A2 GeneProduct ncbigene:26189
SUCNR1 GeneProduct ncbigene:56670
MC3R GeneProduct ncbigene:4159
PTGDR GeneProduct ncbigene:5729
CYSLTR1 GeneProduct ncbigene:10800
GPR30 GeneProduct ncbigene:2852
GPR4 GeneProduct ncbigene:2828
ADRA2B GeneProduct ncbigene:151
GPR20 GeneProduct ncbigene:2843
CCR1 GeneProduct ncbigene:1230
NTSR1 GeneProduct ncbigene:4923
AGTR2 GeneProduct ncbigene:186
C3AR1 GeneProduct ncbigene:719
MC4R GeneProduct ncbigene:4160
AVPR2 GeneProduct ncbigene:554
GPR27 GeneProduct ncbigene:2850
CHRM1 GeneProduct ncbigene:1128
HRH1 GeneProduct ncbigene:3269
PPYR1 GeneProduct ncbigene:5540
AVPR1A GeneProduct ncbigene:552
CCR10 GeneProduct ncbigene:2826
GHSR GeneProduct ncbigene:2693
OR2AG1 GeneProduct ncbigene:144125
OR2F1 GeneProduct ncbigene:26211
GPR147 GeneProduct ncbigene:64106
HTR7 GeneProduct ncbigene:3363
HRH2 GeneProduct ncbigene:3274
P2RY12 GeneProduct ncbigene:64805
HTR2C GeneProduct ncbigene:3358
GPR171 GeneProduct ncbigene:29909
OR1Q1 GeneProduct ncbigene:158131
MAS1 GeneProduct ncbigene:4142
MC5R GeneProduct ncbigene:4161
DRD1 GeneProduct ncbigene:1812
GPR18 GeneProduct ncbigene:2841
CCKAR GeneProduct ncbigene:886
OPN1LW GeneProduct ncbigene:5956
EDNRB GeneProduct ncbigene:1910
Q9UDD9 GeneProduct uniprot:Q9UDD9
BDKRB1 GeneProduct ncbigene:623
OR11A1 GeneProduct ncbigene:26531
OR1E1 GeneProduct ncbigene:8387
BDKRB2 GeneProduct ncbigene:624
OR2C1 GeneProduct ncbigene:4993
GPR83 GeneProduct ncbigene:10888
NPY2R GeneProduct ncbigene:4887
SSTR3 GeneProduct ncbigene:6753
HTR1D GeneProduct ncbigene:3352
OR6B1 GeneProduct ncbigene:135946
CXCR4 GeneProduct ncbigene:7852
GPR75 GeneProduct ncbigene:10936
CCR5 GeneProduct ncbigene:1234
GPR12 GeneProduct ncbigene:2835
CCR7 GeneProduct ncbigene:1236
GPR25 GeneProduct ncbigene:2848
CCR9 GeneProduct ncbigene:10803
OR2H1 GeneProduct ncbigene:26716
OR1I1 GeneProduct ncbigene:126370
CHRM5 GeneProduct ncbigene:1133
OR3A4 GeneProduct ncbigene:390756


  1. GPCRDB: an information system for G protein-coupled receptors. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, et al. Nucleic Acids Res. 1998 Jan 1;26(1):275–9. PubMed Europe PMC Scholia
  2. Classifying G-protein coupled receptors with support vector machines. Karchin R, Karplus K, Haussler D. Bioinformatics. 2002 Jan;18(1):147–59. PubMed Europe PMC Scholia