GPCRs, small ligand (WP353)

Mus musculus

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] These small ligand receptors are part of the Rhodopsin-like family of GPCRs. Source: [ Wikipedia]


Nathan Salomonis , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


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Mus musculus



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Melatonin Metabolite hmdb:HMDB0001389
Mtnr1a GeneProduct ncbigene:17773
Cnr2 GeneProduct ncbigene:12802
Ptger1 GeneProduct ncbigene:19216
Ptger2 GeneProduct ncbigene:19217
S1pr2 GeneProduct ncbigene:14739
Ptger4 GeneProduct ncbigene:19219
S1pr3 GeneProduct ncbigene:13610
S1pr1 GeneProduct ncbigene:13609
Cnr1 GeneProduct ncbigene:12801
Tbxa2r GeneProduct ncbigene:21390
Ptafr GeneProduct ncbigene:19204
Lpar1 GeneProduct ncbigene:14745
Ptgir GeneProduct ncbigene:19222
Ptgdr GeneProduct ncbigene:19214
Ptger3 GeneProduct ncbigene:19218
S1pr4 GeneProduct ncbigene:13611
Mtnr1b GeneProduct ncbigene:244701
Ptgfr GeneProduct ncbigene:19220