Sphingolipid metabolism: integrated pathway (WP4726)
Homo sapiens
New PW, homology converted
Authors
Denise Slenter , Kristina Hanspers , Eric Weitz , Conroy lipids , and Egon WillighagenActivity
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Cited In
- Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature review (2022).
- Tissue-specific pathway activities: A retrospective analysis in COVID-19 patients (2022).
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
cholesterol biosynthetic pathway sphingolipid biosynthetic pathway sphingomyelin metabolic pathway sphingolipid metabolic pathway| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| ATP | Metabolite | chebi:30616 | |
| 3-keto-sphinganine | Metabolite | lipidmaps:LMSP01020002 | |
| Palmitoyl-CoA | Metabolite | lipidmaps:LMFA07050360 | aka CoA(16:0) |
| Serine | Metabolite | pubchem.compound:5951 | |
| Hexadecanal | Metabolite | lipidmaps:LMFA06000088 | |
| Ethanolamine-phosphate | Metabolite | pubchem.compound:1015 | |
| H2O | Metabolite | chebi:15377 | |
| Sphingosine | Metabolite | lipidmaps:LMSP01010001 | |
| Sphinganine | Metabolite | lipidmaps:LMSP01020001 | |
| Sphinganine-1-phosphate | Metabolite | lipidmaps:LMSP01050002 | |
| C16 SM | Metabolite | lipidmaps:LMSP03010003 | SM = sphingomyelin |
| C16 GlcCer | Metabolite | lipidmaps:LMSP0501AA03 | |
| C16DH SM | Metabolite | lipidmaps:LMSP03010004 | SM = sphingomyelin |
| C16DH GlcCer | Metabolite | lipidmaps:LMSP0501AA04 | |
| Sphingosine-1-phosphate | Metabolite | lipidmaps:LMSP01050001 | |
| 1-Hexadecenal | Metabolite | lipidmaps:LMFA06000088 | |
| CoA(16:0) | Metabolite | lipidmaps:LMFA07050360 | |
| CoA(18:0) | Metabolite | chebi:15541 | |
| CoA(20:0) | Metabolite | chebi:15527 | |
| CoA(22:0) | Metabolite | cas:24330-89-0 | AKA 'Coenzyme A, S-docosanoate' |
| CoA(24:0) | Metabolite | cas:24305-30-4 | AKA 'Coenzyme A, S-(tetracosanoate)' |
| CoA(24:1) | Metabolite | cas:88362-35-0 | AKA 'Coenzyme A, S-(15Z)-15-tetracosenoate' |
| C16DH-Cer | Metabolite | lipidmaps:LMSP02020001 | |
| CoA(26:0) | Metabolite | cas:99313-57-2 | AKA 'Coenzyme A, S-hexacosanoate' |
| CoA(26:1) | Metabolite | lipidmaps:LMFA07050099 | |
| ADP | Metabolite | chebi:456216 | |
| C16 Cer | Metabolite | lipidmaps:LMSP02010004 | |
| C18 SM | Metabolite | lipidmaps:LMSP03010001 | SM = sphingomyelin |
| C18 GlcCer | Metabolite | lipidmaps:LMSP0501AA05 | |
| C18DH SM | Metabolite | lipidmaps:LMSP03010020 | SM = sphingomyelin |
| C18DH GlcCer | Metabolite | lipidmaps:LMSP0501AA19 | |
| C18DH-Cer | Metabolite | lipidmaps:LMSP02020008 | |
| C18 Cer | Metabolite | lipidmaps:LMSP02010006 | |
| C20 SM | Metabolite | lipidmaps:LMSP03010005 | SM = sphingomyelin |
| C20 GlcCer | Metabolite | lipidmaps:LMSP0501AA06 | |
| C20DH SM | Metabolite | lipidmaps:LMSP03010021 | SM = sphingomyelin |
| C20DH GlcCer | Metabolite | lipidmaps:LMSP0501AA20 | |
| C20DH-Cer | Metabolite | lipidmaps:LMSP02020009 | |
| C20 Cer | Metabolite | lipidmaps:LMSP02010007 | |
| C22 SM | Metabolite | lipidmaps:LMSP03010006 | SM = sphingomyelin |
| C22 GlcCer | Metabolite | lipidmaps:LMSP0501AA07 | |
| C22DH SM | Metabolite | lipidmaps:LMSP03010022 | SM = sphingomyelin |
| C22DH GlcCer | Metabolite | lipidmaps:LMSP0501AA21 | |
| C22DH-Cer | Metabolite | lipidmaps:LMSP02020010 | |
| C22 Cer | Metabolite | lipidmaps:LMSP02010008 | |
| C24 SM | Metabolite | lipidmaps:LMSP03010008 | SM = sphingomyelin |
| C24 GlcCer | Metabolite | lipidmaps:LMSP0501AA09 | |
| C24DH SM | Metabolite | lipidmaps:LMSP03010024 | SM = sphingomyelin |
| C24DH GlcCer | Metabolite | lipidmaps:LMSP0501AA23 | |
| C24DH-Cer | Metabolite | lipidmaps:LMSP02020012 | |
| C24 Cer | Metabolite | lipidmaps:LMSP02010012 | |
| C24:1 SM | Metabolite | lipidmaps:LMSP03010007 | SM = sphingomyelin |
| C24:1 GlcCer | Metabolite | lipidmaps:LMSP0501AA08 | |
| C24:1DH SM | Metabolite | lipidmaps:LMSP03010023 | SM = sphingomyelin |
| C24:1DH GlcCer | Metabolite | lipidmaps:LMSP0501AA22 | |
| C24:1DH-Cer | Metabolite | lipidmaps:LMSP02020011 | |
| C24:1 Cer | Metabolite | lipidmaps:LMSP02010009 | |
| C26:1 SM | Metabolite | lipidmaps:LMSP03010009 | SM = sphingomyelin |
| C26:1 GlcCer | Metabolite | lipidmaps:LMSP0501AA10 | |
| C26:1DH SM | Metabolite | lipidmaps:LMSP03010025 | SM = sphingomyelin |
| C26:1DH GlcCer | Metabolite | lipidmaps:LMSP0501AA24 | |
| C26:1DH-Cer | Metabolite | lipidmaps:LMSP02020013 | |
| C26:1 Cer | Metabolite | lipidmaps:LMSP02010010 | |
| C26 SM | Metabolite | lipidmaps:LMSP03010010 | SM = sphingomyelin |
| C26 GlcCer | Metabolite | lipidmaps:LMSP0501AA11 | |
| C26DH SM | Metabolite | lipidmaps:LMSP03010026 | SM = sphingomyelin |
| C26DH GlcCer | Metabolite | lipidmaps:LMSP0501AA25 | |
| C26DH-Cer | Metabolite | lipidmaps:LMSP02020014 | |
| C26 Cer | Metabolite | lipidmaps:LMSP02010011 | |
| Ethanolamine-phosphate | Metabolite | pubchem.compound:1015 | |
| Ppap2a | GeneProduct | uniprot:O14494 | No homologues found for original id L:19012 |
| CERK | Protein | ensembl:ENSG00000100422 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223753 |
| SGPP1 | Protein | ensembl:ENSG00000126821 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JI99 |
| ASAH1 | Protein | ensembl:ENSG00000104763 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9WV54 |
| SGMS1 | Protein | ensembl:ENSG00000198964 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208449 |
| SPHK2 | Protein | ensembl:ENSG00000063176 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JIA7 |
| SGPL1 | Protein | ensembl:ENSG00000166224 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20397 |
| UGCG | Protein | ensembl:ENSG00000148154 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22234 |
| SPTLC1 | Protein | ensembl:ENSG00000090054 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:268656 |
| SPHK1 | Protein | ensembl:ENSG00000176170 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CI15 |
| DEGS1 | Protein | ensembl:ENSG00000143753 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13244 |
| KDSR | Protein | ensembl:ENSG00000119537 | AKA Fvt1Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q6GV12 |
| SPTLC2 | Protein | ensembl:ENSG00000100596 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P97363 |
| CERS4 | Protein | ensembl:ENSG00000090661 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260 |
| CERS5 | Protein | ensembl:ENSG00000139624 | AKA Lass5Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9D6K9 |
| CERS6 | Protein | ensembl:ENSG00000172292 | AKA Lass6Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8C172 |
| SMPD1 | Protein | ensembl:ENSG00000166311 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20597 |
| DEGS2 | Protein | ensembl:ENSG00000168350 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:70059 |
| SGMS2 | Protein | ensembl:ENSG00000164023 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74442 |
| PLPP3 | Protein | ensembl:ENSG00000162407 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67916 |
| Ppap2c | Protein | uniprot:O43688 | |
| UGT8 | Protein | ensembl:ENSG00000174607 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22239 |
| CERS1 | Protein | ensembl:ENSG00000223802 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P27545 |
| CERS4 | Protein | ensembl:ENSG00000090661 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260 |
| CERS2 | Protein | ensembl:ENSG00000143418 | Original LipidMaps annotationHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:76893 |
| CERS3 | Protein | ensembl:ENSG00000154227 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1A3B0 |
| SGPP2 | Protein | ensembl:ENSG00000163082 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q810K3 |
| SPHK2 | Protein | ensembl:ENSG00000063176 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9JIA7 |
| SPHK1 | Protein | ensembl:ENSG00000176170 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CI15 |
| SGPL1 | Protein | ensembl:ENSG00000166224 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20397 |
| CERS4 | Protein | ensembl:ENSG00000090661 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260 |
| CERS2 | Protein | ensembl:ENSG00000143418 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:76893 |
| CERS4 | Protein | ensembl:ENSG00000090661 | Protein found in literature (not in original LipidMapsPW)Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67260 |
| CERS5 | Protein | ensembl:ENSG00000139624 | AKA Lass5Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9D6K9 |
| CERS6 | Protein | ensembl:ENSG00000172292 | AKA Lass6Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8C172 |
| CERK | Protein | ensembl:ENSG00000100422 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223753 |
| UGCG | Protein | ensembl:ENSG00000148154 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22234 |
| SMPD1 | Protein | ensembl:ENSG00000166311 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20597 |
| SGMS1 | Protein | ensembl:ENSG00000198964 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208449 |
| SGMS2 | Protein | ensembl:ENSG00000164023 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74442 |
| UGT8 | Protein | ensembl:ENSG00000174607 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22239 |
| CERS3 | Protein | ensembl:ENSG00000154227 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q1A3B0 |
References
- Characterization of murine sphingosine-1-phosphate phosphohydrolase. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S. J Biol Chem. 2002 Mar 15;277(11):8920–7. PubMed Europe PMC Scholia
- De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. Merrill AH Jr. J Biol Chem. 2002 Jul 19;277(29):25843–6. PubMed Europe PMC Scholia
- Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Mizutani Y, Kihara A, Igarashi Y. Biochem J. 2005 Aug 15;390(Pt 1):263–71. PubMed Europe PMC Scholia
- LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. Lahiri S, Futerman AH. J Biol Chem. 2005 Oct 7;280(40):33735–8. PubMed Europe PMC Scholia
- Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, et al. FEBS Lett. 2007 Nov 13;581(27):5289–94. PubMed Europe PMC Scholia
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
- Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, et al. J Biol Chem. 2016 Mar 25;291(13):6989–7003. PubMed Europe PMC Scholia