Sphingolipid Metabolism (general overview) (Mus musculus)

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31N-acyl chains:Ppap2aUgcgSgpp1Degs1Asah1HexadecanalSgpl1Sptlc2CerkSphingosineEthanolamine-phosphateSgms1SerineATPSphk2Sptlc1H2OPalmitoyl-CoAKdsr3-keto-sphinganineSphk12Sphinganine222Sphinganine-1-phosphateDH-Ceramide2CerS4CerS5CerS6CeramideCer-1-P2DH-Cer-1-PSMGlc-CerDH-SMDH-Glc-CerGal-CerDH-Gal-CerSmpd1Degs2Sgms2Sphingosine-1-phosphate1-HexadecenalPpap2bPpap2cCoA(16:0)Ugt8aCoA(18:0)CoA(20:0)CoA(22:0)CoA(24:0)CoA(24:1)CoA(16:0)CoA(18:0)CoA(20:0)CoA(22:0)CoA(24:0)CoA(24:1)DH-CeramideDH-CeramideDH-CeramideDH-CeramideCerS1CerS4Cers2CoA(26:0)CoA(26:1)DH-CeramideCers3CoA(26:0)CoA(26:1)ADPSgpp2


Description

This pathway is inspired by the Lipidmaps>Sphingolipids pathway [1].

Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules. This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide. All products are annotated with a lipid-class identifier.

The integrated pathway can be found here.

Quality Tags

Ontology Terms

 

Bibliography

  1. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S; ''Characterization of murine sphingosine-1-phosphate phosphohydrolase.''; J Biol Chem, 2002 PubMed Europe PMC
  2. Merrill AH Jr; ''De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.''; J Biol Chem, 2002 PubMed Europe PMC
  3. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''''; , PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106333view08:52, 21 August 2019DeSlModified description
106332view08:51, 21 August 2019DeSlAdded general LipidMaps publication.
106260view13:29, 19 August 2019DeSlOntology Term : 'sphingomyelin metabolic pathway' added !
106259view13:29, 19 August 2019DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
106254view13:25, 19 August 2019DeSlModified description
106253view13:25, 19 August 2019DeSlModified title
106245view09:02, 19 August 2019DeSlAnnotated top part of PW with CoA-acyl chains.
106244view09:00, 19 August 2019DeSlAnnotated CoA(xx:x) as much as possible.
106243view08:46, 19 August 2019DeSlUpdated Rhea IDs on left hand side of PW; added additional protein group for backward reaction Sphinganine-1P to Sphinganine including lit. ref.
106242view08:29, 19 August 2019DeSlAnnotated missing protein IDs, converted all GeneProducts to Proteins
106241view08:19, 19 August 2019DeSlModified description
104575view10:23, 1 June 2019EgonwRemoved a unexpected trailing 0.
103980view05:12, 23 April 2019EgonwID of the class.
102933view13:11, 29 January 2019DeSlAdded info from first lit ref.
102932view13:05, 29 January 2019DeSlOntology Term : 'sphingolipid metabolic pathway' added !
98562view13:24, 17 September 2018DeSlChanged layout slightly, to avoid overlapping interactions.
98561view13:21, 17 September 2018DeSlModified description
98560view13:07, 17 September 2018DeSlChanged layout slightly.
98559view13:05, 17 September 2018DeSlAdded specific proteins for different CoA-tail reactions.
98558view12:31, 17 September 2018DeSlAdded database for Ppap2c.
98557view12:27, 17 September 2018DeSlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-HexadecenalMetaboliteLMFA06000088 (LIPID MAPS)
3-keto-sphinganineMetaboliteLMSP01020002 (LIPID MAPS)
ADPMetabolite456216 (ChEBI)
ATPMetabolite30616 (ChEBI)
Asah1ProteinQ9WV54 (Uniprot-TrEMBL)
Cer-1-PMetaboliteLMSP02050000 (LIPID MAPS)
CerS1ProteinP27545 (Uniprot-TrEMBL)
CerS4Protein67260 (Entrez Gene)
CerS5Protein67260 (Entrez Gene)
CerS6Protein241447 (Entrez Gene)
CeramideMetaboliteLMSP02010000 (LIPID MAPS)
CerkProtein223753 (Entrez Gene)
Cers2Protein76893 (Entrez Gene)
Cers3ProteinQ1A3B0 (Uniprot-TrEMBL)
CoA(16:0)MetaboliteLMFA07050360 (LIPID MAPS)
CoA(18:0)Metabolite15541 (ChEBI)
CoA(20:0)Metabolite15527 (ChEBI)
CoA(22:0)Metabolite24330-89-0 (CAS) AKA "Coenzyme A, S-​docosanoate"
CoA(24:0)Metabolite24305-30-4 (CAS) AKA "Coenzyme A, S-​(tetracosanoate)​"
CoA(24:1)Metabolite88362-35-0 (CAS) AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"
CoA(26:0)Metabolite99313-57-2 (CAS)
CoA(26:1)Metabolite
DH-Cer-1-PMetaboliteLMSP020500A0 (LIPID MAPS)
DH-CeramideMetaboliteLMSP02020000 (LIPID MAPS)
DH-Gal-CerMetabolite
DH-Glc-CerMetabolite
DH-SMMetaboliteLMSP030100A0 (LIPID MAPS)
Degs1Protein13244 (Entrez Gene)
Degs2Protein70059 (Entrez Gene)
Ethanolamine-phosphateMetabolite1015 (PubChem-compound)
Gal-CerMetaboliteLMSP0501AC00 (LIPID MAPS)
Glc-CerMetaboliteLMSP0501AA00 (LIPID MAPS)
H2OMetabolite15377 (ChEBI)
HexadecanalMetaboliteLMFA06000088 (LIPID MAPS)
KdsrProteinQ6GV12 (Uniprot-TrEMBL)
Palmitoyl-CoAMetaboliteLMFA07050360 (LIPID MAPS) aka CoA(16:0)
Ppap2aProtein19012 (Entrez Gene)
Ppap2bProtein67916 (Entrez Gene)
Ppap2cProtein50784 (NCBI Protein)
SMMetaboliteLMSP0301 (LIPID MAPS)
SerineMetabolite5951 (PubChem-compound)
Sgms1Protein208449 (Entrez Gene)
Sgms2Protein74442 (Entrez Gene)
Sgpl1Protein20397 (Entrez Gene)
Sgpp1ProteinQ9JI99 (Uniprot-TrEMBL)
Sgpp2ProteinQ810K3 (Uniprot-TrEMBL)
Smpd1Protein20597 (Entrez Gene)
Sphinganine-1-phosphateMetaboliteLMSP01050002 (LIPID MAPS)
SphinganineMetaboliteLMSP01020001 (LIPID MAPS)
Sphingosine-1-phosphateMetaboliteLMSP01050001 (LIPID MAPS)
SphingosineMetaboliteLMSP01010001 (LIPID MAPS)
Sphk1ProteinQ8CI15 (Uniprot-TrEMBL)
Sphk2ProteinQ9JIA7 (Uniprot-TrEMBL)
Sptlc1Protein268656 (Entrez Gene)
Sptlc2ProteinP97363 (Uniprot-TrEMBL)
UgcgProtein22234 (Entrez Gene)
Ugt8aProtein22239 (Entrez Gene)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
3-keto-sphinganineSphinganinemim-conversion22642 (Rhea)
ADPmim-conversion15466 (Rhea)
ATPmim-conversion15466 (Rhea)
H2Omim-conversion27515 (Rhea)
Palmitoyl-CoA3-keto-sphinganinemim-conversion14762 (Rhea)
Sphinganine-1-phosphateSphinganinemim-conversion27515 (Rhea)
SphinganineSphinganine-1-phosphatemim-conversion15466 (Rhea)
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