Glutamate degradation IX (WP503)

Saccharomyces cerevisiae

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In S. cerevisiae cells, the amino group of glutamate and the amide group of glutamine are the source of nitrogen for all other macromolecules. In order to provide ammonia for the synthesis of glutamine during growth on glutamate-yielding nitrogen sources, cells degrade glutamate into ammonia. The main pathway for S. cerevisiae glutamate degradation is catalyzed by the NAD dependent glutamate dehydrogenase (GDH2). Description adapted from on https://pathway.yeastgenome.org/.

Authors

Jessica Heckman , Christine Chichester , Egon Willighagen , Max Van Son , Kristina Hanspers , and Eric Weitz

Activity

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

classic metabolic pathway glutamate degradation pathway IX

Participants

Label Type Compact URI Comment
2-Oxoglutarate Metabolite chebi:30915
H2O Metabolite chebi:15377
NADH Metabolite cas:53-84-9
L-glutamate Metabolite cas:56-86-0
NAD Metabolite chebi:13389
Ammonia Metabolite chebi:16134
H+ Metabolite hmdb:HMDB59597
GDH2 GeneProduct sgd:S000002374

References

  1. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY-3322