Nod-like receptor (NLR) signaling pathway (WP1256)

Mus musculus

Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.


Daniela Digles , Alex Pico , Eric Weitz , and Egon Willighagen


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Mus musculus



Pathway Ontology

NOD-like receptor signaling pathway


Label Type Compact URI Comment
Erbb2ip GeneProduct ncbigene:59079
Chuk GeneProduct ncbigene:12675
Ikbkg GeneProduct ncbigene:16151
RelA GeneProduct ncbigene:19697
Mapk8 GeneProduct ncbigene:26419
Ephb2 GeneProduct ncbigene:13844
Map3k7 GeneProduct ncbigene:26409
Ikbkb GeneProduct ncbigene:16150
Cd40 GeneProduct ncbigene:21939


  1. Intracellular pattern recognition receptors in the host response. Meylan E, Tschopp J, Karin M. Nature. 2006 Jul 6;442(7098):39–44. PubMed Europe PMC Scholia
  2. Nod-like proteins in immunity, inflammation and disease. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE. Nat Immunol. 2006 Dec;7(12):1250–7. PubMed Europe PMC Scholia
  3. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Mariathasan S, Monack DM. Nat Rev Immunol. 2007 Jan;7(1):31–40. PubMed Europe PMC Scholia
  4. Nod-like proteins in inflammation and disease. Carneiro LAM, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH. J Pathol. 2008 Jan;214(2):136–48. PubMed Europe PMC Scholia
  5. Signal transduction pathways used by NLR-type innate immune receptors. Kufer TA. Mol Biosyst. 2008 May;4(5):380–6. PubMed Europe PMC Scholia
  6. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Shaw MH, Reimer T, Kim YG, Nuñez G. Curr Opin Immunol. 2008 Aug;20(4):377–82. PubMed Europe PMC Scholia