Autophagy in pancreatic ductal adenocarcinoma (WP5331)

Homo sapiens

This pathway demonstrates autophagy upregulation during pancreatic ductal adenocarcinoma (PDAC). It covers autophagy accumulation as well as how this promotes cell proliferation in tumor microenvironment. Autophagy in PDAC affects mTOR signaling pathways as well as MAPK signaling pathway.


Ncananfiliz , Isabel Wassink , Egon Willighagen , and Denise Slenter


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Homo sapiens


CPTAC Diseases


Pathway Ontology

pancreatic cancer pathway autophagy pathway disease pathway


Label Type Compact URI Comment
reactive oxygen species Metabolite chebi:26523
MITF GeneProduct ensembl:ENSG00000187098
PRKN GeneProduct ensembl:ENSG00000185345
TP53 GeneProduct ensembl:ENSG00000141510
PINK1 GeneProduct ensembl:ENSG00000158828
ATG7 GeneProduct ensembl:ENSG00000197548
TFEB GeneProduct ensembl:ENSG00000112561
BECN1 GeneProduct ensembl:ENSG00000126581
STAT3 GeneProduct ensembl:ENSG00000168610
MAP1LC3B GeneProduct ensembl:ENSG00000140941
TFE3 GeneProduct ensembl:ENSG00000068323
NFE2L2 GeneProduct ensembl:ENSG00000116044
SHOC2 GeneProduct ensembl:ENSG00000108061
KRAS GeneProduct ensembl:ENSG00000133703
MDM2 GeneProduct ensembl:ENSG00000135679
HMGB1 GeneProduct ensembl:ENSG00000189403
SQSTM1 GeneProduct ensembl:ENSG00000161011
VMP1 GeneProduct ensembl:ENSG00000062716
NFKB1 GeneProduct ensembl:ENSG00000109320
AGER GeneProduct ensembl:ENSG00000204305
IPO8 GeneProduct ensembl:ENSG00000133704


  1. Molecular Pathways Controlling Autophagy in Pancreatic Cancer. New M, Van Acker T, Long JS, Sakamaki JI, Ryan KM, Tooze SA. Front Oncol. 2017 Mar 3;7:28. PubMed Europe PMC Scholia
  2. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, et al. Cancer Cell. 2017 Dec 11;32(6):824-839.e8. PubMed Europe PMC Scholia
  3. Regulation and function of autophagy in pancreatic cancer. Li J, Chen X, Kang R, Zeh H, Klionsky DJ, Tang D. Autophagy. 2021 Nov;17(11):3275–96. PubMed Europe PMC Scholia
  4. Autophagy in pancreatic cancer. Guo C, Zhao Y. J Mol Cell Biol. 2022 Jan 21;13(11):786–90. PubMed Europe PMC Scholia