Network map of SARS-CoV-2 signaling pathway (WP5115)

Homo sapiens

This pathway shows protein-protein interactions and downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation. Each event is color-coded as described in the pathway legend. Information on site and residue of post-translational modification are also included.


Dr. T. S. Keshava Prasad , Friederike Ehrhart , Eric Weitz , Egon Willighagen , Susan Coort , Martijn Van De Garde , John Figueira Hasbun , Lars Willighagen , and Hiromasa Ono


last edited

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Homo sapiens




Pathway Ontology

disease pathway respiratory system disease pathway

Disease Ontology

severe acute respiratory syndrome


Label Type Compact URI Comment
Cytochrome C Metabolite chebi:18070
CASP3 GeneProduct ensembl:ENSG00000164305
CASP8 GeneProduct hgnc.symbol:CASP8
CASP9 GeneProduct hgnc.symbol:CASP9
STAT1 GeneProduct hgnc.symbol:STAT1
JAK2 GeneProduct hgnc.symbol:JAK2
MYD88 GeneProduct hgnc.symbol:MYD88
IRAK1 GeneProduct ncbigene:3654
TRAF6 GeneProduct ncbigene:7189
SMAD5 GeneProduct ncbigene:4090
SMAD1 GeneProduct ncbigene:4086
FGB GeneProduct hgnc.symbol:FGB
SERPINE1 GeneProduct hgnc.symbol:SERPINE1
FGG GeneProduct hgnc.symbol:FGG
ITGA3 GeneProduct hgnc.symbol:ITGA3
COL7A1 GeneProduct hgnc.symbol:COL7A1
FN1 GeneProduct hgnc.symbol:FN1
FOS GeneProduct hgnc.symbol:FOS
EGR1 GeneProduct hgnc.symbol:EGR1
PTGS2 GeneProduct hgnc.symbol:PTGS2
JUN GeneProduct hgnc.symbol:JUN
DUSP1 GeneProduct hgnc.symbol:DUSP1
ITCH GeneProduct hgnc.symbol:ITCH
MAVS GeneProduct ensembl:ENSG00000088888
TANK GeneProduct ena.embl:TANK
TRAF2 GeneProduct hgnc.symbol:TRAF2
CXCL2 GeneProduct hgnc.symbol:CXCL2
TNF GeneProduct hgnc.symbol:TNF
IL6 GeneProduct hgnc.symbol:IL6
TRAF3 GeneProduct ensembl:ENSG00000131323
IRF3 GeneProduct hgnc.symbol:IRF3
ISG56 GeneProduct hgnc.symbol:ISG56
ISRE GeneProduct hgnc.symbol:ISRE
MX1 GeneProduct hgnc.symbol:MX1
IFIT1 GeneProduct hgnc.symbol:IFIT1
IRF9 GeneProduct hgnc.symbol:IRF9
IFI27 GeneProduct hgnc.symbol:IFI27
BST2 GeneProduct hgnc.symbol:BST2
IFI6 GeneProduct hgnc.symbol:IFI6
IFITM1 GeneProduct hgnc.symbol:IFITM1
FOS GeneProduct hgnc.symbol:FOS
JUN GeneProduct hgnc.symbol:JUN
DUSP1 GeneProduct hgnc.symbol:DUSP1
IRF27 GeneProduct hgnc.symbol:IRF27
JUNB GeneProduct hgnc.symbol:JUNB
IFITM3 GeneProduct hgnc.symbol:IFITM3
IFI27 GeneProduct hgnc.symbol:IFI27
IFIH1 GeneProduct hgnc.symbol:IFIH1
ACE2 GeneProduct ensembl:ENSG00000130234
CXCL8 GeneProduct hgnc.symbol:CXCL8
CCL11 GeneProduct hgnc.symbol:CCL11
IL6 GeneProduct ensembl:ENSG00000136244
CXCL9 GeneProduct hgnc.symbol:CXCL9
CCR5 GeneProduct hgnc.symbol:CCR5
CXCR1 GeneProduct hgnc.symbol:CXCR1
CXCR2 GeneProduct hgnc.symbol:CXCR2
TNF GeneProduct hgnc.symbol:TNF
IL1RA GeneProduct hgnc.symbol:IL1RA
CCL20 GeneProduct hgnc.symbol:CCL20
IL6 GeneProduct ensembl:ENSG00000136244
CXCL6 GeneProduct hgnc.symbol:CXCL6
CD226 GeneProduct hgnc.symbol:CD226
CCR6 GeneProduct hgnc.symbol:CCR6
CXCL16 GeneProduct hgnc.symbol:CXCL16
CXCL1 GeneProduct hgnc.symbol:CXCL1
IL1A GeneProduct hgnc.symbol:IL1A
CXCL2 GeneProduct hgnc.symbol:CXCL2
CD163 GeneProduct hgnc.symbol:CD163
CXCL16 GeneProduct hgnc.symbol:CXCL16
CXCR7 GeneProduct hgnc.symbol:CXCR7
CXCL3 GeneProduct hgnc.symbol:CXCL3
CXCL2 GeneProduct hgnc.symbol:CXCL2
IL1B GeneProduct ensembl:ENSG00000125538
CCL8 GeneProduct hgnc.symbol:CCL8
CXCL5 GeneProduct hgnc.symbol:CXCL5
CXCL8 GeneProduct hgnc.symbol:CXCL8
CCL2 GeneProduct ensembl:ENSG00000108691
IL8 GeneProduct ncbigene:3576
NKRF GeneProduct ncbigene:55922
IL6 GeneProduct ncbigene:3569
MAP1LC3B GeneProduct ncbigene:81631
VPS18 GeneProduct hgnc.symbol:VPS18
LARP1 GeneProduct ncbigene:23367
ULK1 GeneProduct ncbigene:8408
HIF1A GeneProduct ncbigene:3091
PRAS40 GeneProduct ensembl:ENSG00000204673
EIF4EBP1 GeneProduct ncbigene:1978
TNF GeneProduct hgnc.symbol:TNF
CCL8 GeneProduct hgnc.symbol:CCL8
STEAP3 GeneProduct hgnc.symbol:STEAP3
PIAS1 GeneProduct hgnc.symbol:PIAS1
IL17A GeneProduct hgnc.symbol:IL17A
FGA GeneProduct ensembl:ENSG00000171560
SELP GeneProduct ensembl:ENSG00000174175
IFITM3 GeneProduct ensembl:ENSG00000142089
GTSE1 GeneProduct hgnc.symbol:GTSE1
MIP1A GeneProduct hgnc.symbol:MIP1A
IL6 GeneProduct hgnc.symbol:IL6
IL6 GeneProduct hgnc.symbol:IL6
HSPA8 GeneProduct hgnc.symbol:HSPA8
CFP GeneProduct hgnc.symbol:CFP
FGB GeneProduct ensembl:ENSG00000171564
JAK1 GeneProduct hgnc.symbol:JAK1
GMCSF GeneProduct hgnc.symbol:GMCSF
IFI27 GeneProduct hgnc.symbol:IFI27
LCK GeneProduct hgnc.symbol:LCK
CCL27 GeneProduct hgnc.symbol:CCL27
IL1A GeneProduct hgnc.symbol:IL1A
C8A GeneProduct ensembl:ENSG00000157131
CCL26 GeneProduct hgnc.symbol:CCL26
CAMK4 GeneProduct hgnc.symbol:CAMK4
SAA1 GeneProduct ensembl:ENSG00000173432
RPS6 GeneProduct hgnc.symbol:RPS6
IL2R GeneProduct hgnc.symbol:IL2R
CCL5 GeneProduct hgnc.symbol:CCL5
IGFBP3 GeneProduct hgnc.symbol:IGFBP3
CCL1 GeneProduct hgnc.symbol:CCL1
TP53I3 GeneProduct hgnc.symbol:TP53I3
CRP GeneProduct hgnc.symbol:CRP
EIF4A2 GeneProduct hgnc.symbol:EIF4A2
ITIH4 GeneProduct ensembl:ENSG00000055955
GCSF GeneProduct hgnc.symbol:GCSF
WDR74 GeneProduct hgnc.symbol:WDR74
CCL4 GeneProduct hgnc.symbol:CCL4
BIRC5 GeneProduct hgnc.symbol:BIRC5
AHR GeneProduct hgnc.symbol:AHR
TNFSF10 GeneProduct hgnc.symbol:TNFSF10
IL18 GeneProduct hgnc.symbol:IL18
CXCL12 GeneProduct hgnc.symbol:CXCL12
MIP1B GeneProduct hgnc.symbol:MIP1B
IL22 GeneProduct hgnc.symbol:IL22
MCP1 GeneProduct hgnc.symbol:MCP1
HRG GeneProduct hgnc.symbol:HRG
GSN GeneProduct hgnc.symbol:GSN
TRO GeneProduct hgnc.symbol:TRO
CCL4 GeneProduct hgnc.symbol:CCL4
ACTB GeneProduct ensembl:ENSG00000075624
CCL21 GeneProduct hgnc.symbol:CCL21
PF4 GeneProduct hgnc.symbol:PF4
IFNG GeneProduct hgnc.symbol:IFNG
APOH GeneProduct hgnc.symbol:APOH
IL1B GeneProduct hgnc.symbol:IL1B
CTSD GeneProduct hgnc.symbol:CTSD
HBB GeneProduct hgnc.symbol:HBB
IL2B GeneProduct hgnc.symbol:IL2B
PDGF GeneProduct hgnc.symbol:PDGF
CXCL9 GeneProduct hgnc.symbol:CXCL9
HP GeneProduct ensembl:ENSG00000257017
IL1RA GeneProduct hgnc.symbol:IL1RA
OAS2 GeneProduct hgnc.symbol:OAS2
IL8 GeneProduct hgnc.symbol:IL8
LRG1 GeneProduct ensembl:ENSG00000171236
C1S GeneProduct ensembl:ENSG00000182326
APOM GeneProduct hgnc.symbol:APOM
CXCL10 GeneProduct hgnc.symbol:CXCL10
FGF2 GeneProduct hgnc.symbol:FGF2
APOA2 GeneProduct hgnc.symbol:APOA2
ACTG1 GeneProduct ensembl:ENSG00000184009
SKAP1 GeneProduct hgnc.symbol:SKAP1
C1QBP GeneProduct hgnc.symbol:C1QBP
CTSD GeneProduct hgnc.symbol:CTSD
CPN1 GeneProduct hgnc.symbol:CPN1
APOA1 GeneProduct hgnc.symbol:APOA1
IL33 GeneProduct hgnc.symbol:IL33
APOL1 GeneProduct hgnc.symbol:APOL1
DDIT4 GeneProduct hgnc.symbol:DDIT4
BTN3A1 GeneProduct hgnc.symbol:BTN3A1
CARD11 GeneProduct hgnc.symbol:CARD11
IL1R2 GeneProduct hgnc.symbol:IL1R2
NFATC3 GeneProduct hgnc.symbol:NFATC3
IL5 GeneProduct hgnc.symbol:IL5
CEBPB GeneProduct hgnc.symbol:CEBPB
PARP2 GeneProduct hgnc.symbol:PARP2
CCL3 GeneProduct hgnc.symbol:CCL3
CTSZ GeneProduct hgnc.symbol:CTSZ
CXCL10 GeneProduct hgnc.symbol:CXCL10
CCNB2 GeneProduct hgnc.symbol:CCNB2
JUNB GeneProduct hgnc.symbol:JUNB
FAM83A GeneProduct hgnc.symbol:FAM83A
CXCL13 GeneProduct hgnc.symbol:CXCL13
IL10 GeneProduct hgnc.symbol:IL10
APOC1 GeneProduct hgnc.symbol:APOC1
LCK GeneProduct hgnc.symbol:LCK
C1R GeneProduct ensembl:ENSG00000159403
CASP5 GeneProduct hgnc.symbol:CASP5
CCL2 GeneProduct hgnc.symbol:CCL2
CALC1 GeneProduct hgnc.symbol:CALC1
FGG GeneProduct ensembl:ENSG00000171557
A1BG GeneProduct ensembl:ENSG00000121410
FYN GeneProduct hgnc.symbol:FYN
IL7 GeneProduct hgnc.symbol:IL7
CTSB GeneProduct hgnc.symbol:CTSB
RAC1 GeneProduct hgnc.symbol:RAC1
CFH GeneProduct ensembl:ENSG00000000971
IL13 GeneProduct hgnc.symbol:IL13
ITIH3 GeneProduct ensembl:ENSG00000162267
HBD GeneProduct hgnc.symbol:HBD
TNF GeneProduct hgnc.symbol:TNF
CD14 GeneProduct ensembl:ENSG00000170458
SERPINA10 GeneProduct ensembl:ENSG00000140093
PTPN6 GeneProduct hgnc.symbol:PTPN6
LGALS3BP GeneProduct ensembl:ENSG00000108679
MAPK8 GeneProduct hgnc.symbol:MAPK8
IL1B GeneProduct hgnc.symbol:IL1B
CXCL10 GeneProduct hgnc.symbol:CXCL10
CFI GeneProduct ensembl:ENSG00000205403
CDK1 GeneProduct hgnc.symbol:CDK1
CCL22 GeneProduct hgnc.symbol:CCL22
LDH GeneProduct hgnc.symbol:LDH
CRP GeneProduct ensembl:ENSG00000132693
LBP GeneProduct ensembl:ENSG00000129988
IL16 GeneProduct hgnc.symbol:IL16
CCL15 GeneProduct hgnc.symbol:CCL15
PRKCQ GeneProduct hgnc.symbol:PRKCQ
RRAS GeneProduct hgnc.symbol:RRAS
TNF GeneProduct hgnc.symbol:TNF
SAA2 GeneProduct ensembl:ENSG00000134339
IL10 GeneProduct hgnc.symbol:IL10
IFNA GeneProduct hgnc.symbol:IFNA
IL9 GeneProduct hgnc.symbol:IL9
IL18RAP GeneProduct hgnc.symbol:IL18RAP
CCL2 GeneProduct hgnc.symbol:CCL2
IL23 GeneProduct hgnc.symbol:IL23
TF GeneProduct hgnc.symbol:TF
IL21 GeneProduct hgnc.symbol:IL21
CFB GeneProduct ensembl:ENSG00000243649
CCL3 GeneProduct hgnc.symbol:CCL3
IL4 GeneProduct hgnc.symbol:IL4
RRM2 GeneProduct hgnc.symbol:RRM2
CCL2 GeneProduct hgnc.symbol:CCL2
APOD GeneProduct hgnc.symbol:APOD
CTSB GeneProduct hgnc.symbol:CTSB
IGLC2 GeneProduct ncbigene:3538
APOA1 GeneProduct hgnc.symbol:APOA1
IL1A GeneProduct hgnc.symbol:IL1A
IGHE GeneProduct ncbigene:3497
HLA-DRA GeneProduct ncbigene:3122
SERPINA5 GeneProduct hgnc.symbol:SERPINA5
CD4 GeneProduct ncbigene:920
CD8A GeneProduct ncbigene:926
IL10 GeneProduct hgnc.symbol:IL10
HLA-DRB1 GeneProduct ncbigene:3123
ALB GeneProduct hgnc.symbol:ALB
IGLL1 GeneProduct ncbigene:3543
PRG3 GeneProduct ncbigene:10394
CD8A GeneProduct ncbigene:925
CRP GeneProduct ncbigene:1401
TPO GeneProduct hgnc.symbol:TPO
MMP25 GeneProduct ncbigene:64386
NLRP3 GeneProduct hgnc.symbol:NLRP3
JUNB GeneProduct hgnc.symbol:JUNB
IFI6 GeneProduct hgnc.symbol:IFI6
IFI44L GeneProduct hgnc.symbol:IFI44L
CCNB1 GeneProduct hgnc.symbol:CCNB1
LBP GeneProduct ncbigene:3929
HLA-DRB4 GeneProduct ncbigene:3126
IGHG4 GeneProduct ncbigene:3503
GP1BA GeneProduct hgnc.symbol:GP1BA
NTRK1 GeneProduct hgnc.symbol:NTRK1
IGHG2 GeneProduct ncbigene:3501
CTSL GeneProduct hgnc.symbol:CTSL
CD2 GeneProduct ncbigene:914
CTSL GeneProduct hgnc.symbol:CTSL
NLRP1 GeneProduct ncbigene:22861
HLA-DRB5 GeneProduct ncbigene:3127
IL1B GeneProduct hgnc.symbol:IL1B
IGHG1 GeneProduct ncbigene:3500
CD247 GeneProduct ncbigene:919
CD3G GeneProduct ncbigene:917
LCK GeneProduct ncbigene:3932
CD3E GeneProduct ncbigene:916
ZAP70 GeneProduct ncbigene:7535
TRBC1 GeneProduct ncbigene:28639
FYN GeneProduct ncbigene:2534
TRAC GeneProduct ncbigene:28755
TBK1 GeneProduct ncbigene:29110
DDX58 GeneProduct hgnc.symbol:DDX58
TNF GeneProduct hgnc.symbol:TNF
AGT GeneProduct hgnc.symbol:AGT
IFNA GeneProduct hgnc.symbol:IFNA
IL17A GeneProduct hgnc.symbol:IL17A
CXCL5 GeneProduct hgnc.symbol:CXCL5
LDH GeneProduct hgnc.symbol:LDH
CRP GeneProduct hgnc.symbol:CRP
MCP1 GeneProduct hgnc.symbol:MCP1
CXCL10 GeneProduct hgnc.symbol:CXCL10
CXCL1 GeneProduct hgnc.symbol:CXCL1
IL1B GeneProduct hgnc.symbol:IL1B
IL10 GeneProduct hgnc.symbol:IL10
LDH GeneProduct hgnc.symbol:LDH
IL1A GeneProduct hgnc.symbol:IL1A
IL12A GeneProduct hgnc.symbol:IL12A
CRP GeneProduct hgnc.symbol:CRP
IL6 GeneProduct hgnc.symbol:IL6
ALB GeneProduct hgnc.symbol:ALB
S Protein ncbiprotein:YP_009724390.1
ACE2 Protein ensembl:ENSG00000130234
TMPRSS2 Protein ncbigene:7226
nsp6 Protein ncbiprotein:YP_009725302
orf7b Protein ncbiprotein:YP_009725318.1
orf3a Protein ncbiprotein:YP_009724391.1
nsp10 Protein ncbiprotein:YP_009725306
M Protein ncbiprotein:YP_009724393.1
S Protein ncbiprotein:YP_009724390.1
nsp2 Protein ncbiprotein:YP_009725298
orf6 Protein ncbiprotein:YP_009724394.1
nsp9 Protein ncbiprotein:YP_009725305
N Protein ncbiprotein:YP_009724397.2
orf9b Protein ncbiprotein:P0DTD2
nsp13 Protein ncbiprotein:YP_009725308
nsp8 Protein ncbiprotein:YP_009725304
orf7a Protein ncbiprotein:YP_009724395.1
orf8 Protein ncbiprotein:YP_009724396.1
BID Protein ncbigene:637
BID Protein ncbigene:637
NFKB2 Protein ncbigene:4791
TGFBR2 Protein hgnc.symbol:TGFBR2
MAPK8 Protein ncbiprotein:NP_001310259.1
IFN1 Protein uniprot:IFN1
IFNB1 Protein uniprot:P01574
MAPK1 Protein ncbiprotein:NP_002736.3
MAPK3 Protein ncbiprotein:NP_002737.2
PLA2G4A Protein ncbiprotein:NP_077734.1
MAPK14 Protein ncbiprotein:NP_001306.1
IFNB1 Protein uniprot:P01574
SQSTM1 Protein ncbiprotein:NP_003891.1
TAX1BP1 Protein ncbiprotein:TAX1BP1
NBR1 Protein ncbiprotein:NBR1
GABARAPL2 Protein ncbigene:11345
VPS16 Protein ncbigene:64601
VPS11 Protein ncbigene:55823
VPS41 Protein ncbigene:27072
VPS36 Protein ncbigene:51028
VPS33A Protein ncbigene:65082
RPS6KB1 Protein ncbiprotein:NP_003152.1
MLST8 Protein ncbigene:64223
DEPTOR Protein ncbigene:64798
RPTOR Protein ncbigene:57521
RHEB Protein ncbigene:6009
ATG13 Protein ncbigene:9776
AKT1 Protein uniprot:P31749
TSC2 Protein uniprot:P31749
EIF4E Protein hgnc.symbol:EIF4E
PI3K Protein uniprot:P31749
MTOR Protein ncbigene:2475
IKBKG Protein ncbigene:8517


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