Network map of SARS-CoV-2 signaling pathway (WP5115)
Homo sapiens
This pathway shows protein-protein interactions and downstream molecular events regulated by SARS-CoV-2 including molecular association, catalysis, and gene regulation. Each event is color-coded as described in the pathway legend. Information on site and residue of post-translational modification are also included.
Authors
Dr. T. S. Keshava Prasad , Friederike Ehrhart , Eric Weitz , Egon Willighagen , Susan Coort , Martijn Van De Garde , John Figueira Hasbun , Lars Willighagen , and Hiromasa OnoActivity
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Cited In
- Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor (2022).
- SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19 (2021).
- SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis (2022).
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
disease pathway respiratory system disease pathwayDisease Ontology
severe acute respiratory syndromeLabel | Type | Compact URI | Comment |
---|---|---|---|
Cytochrome C | Metabolite | chebi:18070 | |
CASP3 | GeneProduct | ensembl:ENSG00000164305 | |
CASP8 | GeneProduct | hgnc.symbol:CASP8 | |
CASP9 | GeneProduct | hgnc.symbol:CASP9 | |
STAT1 | GeneProduct | hgnc.symbol:STAT1 | |
JAK2 | GeneProduct | hgnc.symbol:JAK2 | |
MYD88 | GeneProduct | hgnc.symbol:MYD88 | |
IRAK1 | GeneProduct | ncbigene:3654 | |
TRAF6 | GeneProduct | ncbigene:7189 | |
SMAD5 | GeneProduct | ncbigene:4090 | |
SMAD1 | GeneProduct | ncbigene:4086 | |
FGB | GeneProduct | hgnc.symbol:FGB | |
SERPINE1 | GeneProduct | hgnc.symbol:SERPINE1 | |
FGG | GeneProduct | hgnc.symbol:FGG | |
ITGA3 | GeneProduct | hgnc.symbol:ITGA3 | |
COL7A1 | GeneProduct | hgnc.symbol:COL7A1 | |
FN1 | GeneProduct | hgnc.symbol:FN1 | |
FOS | GeneProduct | hgnc.symbol:FOS | |
EGR1 | GeneProduct | hgnc.symbol:EGR1 | |
PTGS2 | GeneProduct | hgnc.symbol:PTGS2 | |
JUN | GeneProduct | hgnc.symbol:JUN | |
DUSP1 | GeneProduct | hgnc.symbol:DUSP1 | |
ITCH | GeneProduct | hgnc.symbol:ITCH | |
MAVS | GeneProduct | ensembl:ENSG00000088888 | |
TANK | GeneProduct | ena.embl:TANK | |
TRAF2 | GeneProduct | hgnc.symbol:TRAF2 | |
CXCL2 | GeneProduct | hgnc.symbol:CXCL2 | |
TNF | GeneProduct | hgnc.symbol:TNF | |
IL6 | GeneProduct | hgnc.symbol:IL6 | |
TRAF3 | GeneProduct | ensembl:ENSG00000131323 | |
IRF3 | GeneProduct | hgnc.symbol:IRF3 | |
ISG56 | GeneProduct | hgnc.symbol:ISG56 | |
ISRE | GeneProduct | hgnc.symbol:ISRE | |
MX1 | GeneProduct | hgnc.symbol:MX1 | |
IFIT1 | GeneProduct | hgnc.symbol:IFIT1 | |
IRF9 | GeneProduct | hgnc.symbol:IRF9 | |
IFI27 | GeneProduct | hgnc.symbol:IFI27 | |
BST2 | GeneProduct | hgnc.symbol:BST2 | |
IFI6 | GeneProduct | hgnc.symbol:IFI6 | |
IFITM1 | GeneProduct | hgnc.symbol:IFITM1 | |
FOS | GeneProduct | hgnc.symbol:FOS | |
JUN | GeneProduct | hgnc.symbol:JUN | |
DUSP1 | GeneProduct | hgnc.symbol:DUSP1 | |
IRF27 | GeneProduct | hgnc.symbol:IRF27 | |
JUNB | GeneProduct | hgnc.symbol:JUNB | |
IFITM3 | GeneProduct | hgnc.symbol:IFITM3 | |
IFI27 | GeneProduct | hgnc.symbol:IFI27 | |
IFIH1 | GeneProduct | hgnc.symbol:IFIH1 | |
ACE2 | GeneProduct | ensembl:ENSG00000130234 | |
CXCL8 | GeneProduct | hgnc.symbol:CXCL8 | |
CCL11 | GeneProduct | hgnc.symbol:CCL11 | |
IL6 | GeneProduct | ensembl:ENSG00000136244 | |
CXCL9 | GeneProduct | hgnc.symbol:CXCL9 | |
CCR5 | GeneProduct | hgnc.symbol:CCR5 | |
CXCR1 | GeneProduct | hgnc.symbol:CXCR1 | |
CXCR2 | GeneProduct | hgnc.symbol:CXCR2 | |
TNF | GeneProduct | hgnc.symbol:TNF | |
IL1RA | GeneProduct | hgnc.symbol:IL1RA | |
CCL20 | GeneProduct | hgnc.symbol:CCL20 | |
IL6 | GeneProduct | ensembl:ENSG00000136244 | |
CXCL6 | GeneProduct | hgnc.symbol:CXCL6 | |
CD226 | GeneProduct | hgnc.symbol:CD226 | |
CCR6 | GeneProduct | hgnc.symbol:CCR6 | |
CXCL16 | GeneProduct | hgnc.symbol:CXCL16 | |
CXCL1 | GeneProduct | hgnc.symbol:CXCL1 | |
IL1A | GeneProduct | hgnc.symbol:IL1A | |
CXCL2 | GeneProduct | hgnc.symbol:CXCL2 | |
CD163 | GeneProduct | hgnc.symbol:CD163 | |
CXCL16 | GeneProduct | hgnc.symbol:CXCL16 | |
CXCR7 | GeneProduct | hgnc.symbol:CXCR7 | |
CXCL3 | GeneProduct | hgnc.symbol:CXCL3 | |
CXCL2 | GeneProduct | hgnc.symbol:CXCL2 | |
IL1B | GeneProduct | ensembl:ENSG00000125538 | |
CCL8 | GeneProduct | hgnc.symbol:CCL8 | |
CXCL5 | GeneProduct | hgnc.symbol:CXCL5 | |
CXCL8 | GeneProduct | hgnc.symbol:CXCL8 | |
CCL2 | GeneProduct | ensembl:ENSG00000108691 | |
IL8 | GeneProduct | ncbigene:3576 | |
NKRF | GeneProduct | ncbigene:55922 | |
IL6 | GeneProduct | ncbigene:3569 | |
MAP1LC3B | GeneProduct | ncbigene:81631 | |
VPS18 | GeneProduct | hgnc.symbol:VPS18 | |
LARP1 | GeneProduct | ncbigene:23367 | |
ULK1 | GeneProduct | ncbigene:8408 | |
HIF1A | GeneProduct | ncbigene:3091 | |
PRAS40 | GeneProduct | ensembl:ENSG00000204673 | |
EIF4EBP1 | GeneProduct | ncbigene:1978 | |
TNF | GeneProduct | hgnc.symbol:TNF | |
CCL8 | GeneProduct | hgnc.symbol:CCL8 | |
STEAP3 | GeneProduct | hgnc.symbol:STEAP3 | |
PIAS1 | GeneProduct | hgnc.symbol:PIAS1 | |
IL17A | GeneProduct | hgnc.symbol:IL17A | |
FGA | GeneProduct | ensembl:ENSG00000171560 | |
SELP | GeneProduct | ensembl:ENSG00000174175 | |
IFITM3 | GeneProduct | ensembl:ENSG00000142089 | |
GTSE1 | GeneProduct | hgnc.symbol:GTSE1 | |
MIP1A | GeneProduct | hgnc.symbol:MIP1A | |
IL6 | GeneProduct | hgnc.symbol:IL6 | |
IL6 | GeneProduct | hgnc.symbol:IL6 | |
HSPA8 | GeneProduct | hgnc.symbol:HSPA8 | |
CFP | GeneProduct | hgnc.symbol:CFP | |
FGB | GeneProduct | ensembl:ENSG00000171564 | |
JAK1 | GeneProduct | hgnc.symbol:JAK1 | |
GMCSF | GeneProduct | hgnc.symbol:GMCSF | |
IFI27 | GeneProduct | hgnc.symbol:IFI27 | |
LCK | GeneProduct | hgnc.symbol:LCK | |
CCL27 | GeneProduct | hgnc.symbol:CCL27 | |
IL1A | GeneProduct | hgnc.symbol:IL1A | |
C8A | GeneProduct | ensembl:ENSG00000157131 | |
CCL26 | GeneProduct | hgnc.symbol:CCL26 | |
CAMK4 | GeneProduct | hgnc.symbol:CAMK4 | |
SAA1 | GeneProduct | ensembl:ENSG00000173432 | |
RPS6 | GeneProduct | hgnc.symbol:RPS6 | |
IL2R | GeneProduct | hgnc.symbol:IL2R | |
CCL5 | GeneProduct | hgnc.symbol:CCL5 | |
IGFBP3 | GeneProduct | hgnc.symbol:IGFBP3 | |
CCL1 | GeneProduct | hgnc.symbol:CCL1 | |
TP53I3 | GeneProduct | hgnc.symbol:TP53I3 | |
CRP | GeneProduct | hgnc.symbol:CRP | |
EIF4A2 | GeneProduct | hgnc.symbol:EIF4A2 | |
ITIH4 | GeneProduct | ensembl:ENSG00000055955 | |
GCSF | GeneProduct | hgnc.symbol:GCSF | |
WDR74 | GeneProduct | hgnc.symbol:WDR74 | |
CCL4 | GeneProduct | hgnc.symbol:CCL4 | |
BIRC5 | GeneProduct | hgnc.symbol:BIRC5 | |
AHR | GeneProduct | hgnc.symbol:AHR | |
TNFSF10 | GeneProduct | hgnc.symbol:TNFSF10 | |
IL18 | GeneProduct | hgnc.symbol:IL18 | |
CXCL12 | GeneProduct | hgnc.symbol:CXCL12 | |
MIP1B | GeneProduct | hgnc.symbol:MIP1B | |
IL22 | GeneProduct | hgnc.symbol:IL22 | |
MCP1 | GeneProduct | hgnc.symbol:MCP1 | |
HRG | GeneProduct | hgnc.symbol:HRG | |
GSN | GeneProduct | hgnc.symbol:GSN | |
TRO | GeneProduct | hgnc.symbol:TRO | |
CCL4 | GeneProduct | hgnc.symbol:CCL4 | |
ACTB | GeneProduct | ensembl:ENSG00000075624 | |
CCL21 | GeneProduct | hgnc.symbol:CCL21 | |
PF4 | GeneProduct | hgnc.symbol:PF4 | |
IFNG | GeneProduct | hgnc.symbol:IFNG | |
APOH | GeneProduct | hgnc.symbol:APOH | |
IL1B | GeneProduct | hgnc.symbol:IL1B | |
CTSD | GeneProduct | hgnc.symbol:CTSD | |
HBB | GeneProduct | hgnc.symbol:HBB | |
IL2B | GeneProduct | hgnc.symbol:IL2B | |
PDGF | GeneProduct | hgnc.symbol:PDGF | |
CXCL9 | GeneProduct | hgnc.symbol:CXCL9 | |
HP | GeneProduct | ensembl:ENSG00000257017 | |
IL1RA | GeneProduct | hgnc.symbol:IL1RA | |
OAS2 | GeneProduct | hgnc.symbol:OAS2 | |
IL8 | GeneProduct | hgnc.symbol:IL8 | |
LRG1 | GeneProduct | ensembl:ENSG00000171236 | |
C1S | GeneProduct | ensembl:ENSG00000182326 | |
APOM | GeneProduct | hgnc.symbol:APOM | |
CXCL10 | GeneProduct | hgnc.symbol:CXCL10 | |
FGF2 | GeneProduct | hgnc.symbol:FGF2 | |
APOA2 | GeneProduct | hgnc.symbol:APOA2 | |
ACTG1 | GeneProduct | ensembl:ENSG00000184009 | |
SKAP1 | GeneProduct | hgnc.symbol:SKAP1 | |
C1QBP | GeneProduct | hgnc.symbol:C1QBP | |
CTSD | GeneProduct | hgnc.symbol:CTSD | |
CPN1 | GeneProduct | hgnc.symbol:CPN1 | |
APOA1 | GeneProduct | hgnc.symbol:APOA1 | |
IL33 | GeneProduct | hgnc.symbol:IL33 | |
APOL1 | GeneProduct | hgnc.symbol:APOL1 | |
DDIT4 | GeneProduct | hgnc.symbol:DDIT4 | |
BTN3A1 | GeneProduct | hgnc.symbol:BTN3A1 | |
CARD11 | GeneProduct | hgnc.symbol:CARD11 | |
IL1R2 | GeneProduct | hgnc.symbol:IL1R2 | |
NFATC3 | GeneProduct | hgnc.symbol:NFATC3 | |
IL5 | GeneProduct | hgnc.symbol:IL5 | |
CEBPB | GeneProduct | hgnc.symbol:CEBPB | |
PARP2 | GeneProduct | hgnc.symbol:PARP2 | |
CCL3 | GeneProduct | hgnc.symbol:CCL3 | |
CTSZ | GeneProduct | hgnc.symbol:CTSZ | |
CXCL10 | GeneProduct | hgnc.symbol:CXCL10 | |
CCNB2 | GeneProduct | hgnc.symbol:CCNB2 | |
JUNB | GeneProduct | hgnc.symbol:JUNB | |
FAM83A | GeneProduct | hgnc.symbol:FAM83A | |
CXCL13 | GeneProduct | hgnc.symbol:CXCL13 | |
IL10 | GeneProduct | hgnc.symbol:IL10 | |
APOC1 | GeneProduct | hgnc.symbol:APOC1 | |
LCK | GeneProduct | hgnc.symbol:LCK | |
C1R | GeneProduct | ensembl:ENSG00000159403 | |
CASP5 | GeneProduct | hgnc.symbol:CASP5 | |
CCL2 | GeneProduct | hgnc.symbol:CCL2 | |
CALC1 | GeneProduct | hgnc.symbol:CALC1 | |
FGG | GeneProduct | ensembl:ENSG00000171557 | |
A1BG | GeneProduct | ensembl:ENSG00000121410 | |
FYN | GeneProduct | hgnc.symbol:FYN | |
IL7 | GeneProduct | hgnc.symbol:IL7 | |
CTSB | GeneProduct | hgnc.symbol:CTSB | |
RAC1 | GeneProduct | hgnc.symbol:RAC1 | |
CFH | GeneProduct | ensembl:ENSG00000000971 | |
IL13 | GeneProduct | hgnc.symbol:IL13 | |
ITIH3 | GeneProduct | ensembl:ENSG00000162267 | |
HBD | GeneProduct | hgnc.symbol:HBD | |
TNF | GeneProduct | hgnc.symbol:TNF | |
CD14 | GeneProduct | ensembl:ENSG00000170458 | |
SERPINA10 | GeneProduct | ensembl:ENSG00000140093 | |
PTPN6 | GeneProduct | hgnc.symbol:PTPN6 | |
LGALS3BP | GeneProduct | ensembl:ENSG00000108679 | |
MAPK8 | GeneProduct | hgnc.symbol:MAPK8 | |
IL1B | GeneProduct | hgnc.symbol:IL1B | |
CXCL10 | GeneProduct | hgnc.symbol:CXCL10 | |
CFI | GeneProduct | ensembl:ENSG00000205403 | |
CDK1 | GeneProduct | hgnc.symbol:CDK1 | |
CCL22 | GeneProduct | hgnc.symbol:CCL22 | |
LDH | GeneProduct | hgnc.symbol:LDH | |
CRP | GeneProduct | ensembl:ENSG00000132693 | |
LBP | GeneProduct | ensembl:ENSG00000129988 | |
IL16 | GeneProduct | hgnc.symbol:IL16 | |
CCL15 | GeneProduct | hgnc.symbol:CCL15 | |
PRKCQ | GeneProduct | hgnc.symbol:PRKCQ | |
RRAS | GeneProduct | hgnc.symbol:RRAS | |
TNF | GeneProduct | hgnc.symbol:TNF | |
SAA2 | GeneProduct | ensembl:ENSG00000134339 | |
IL10 | GeneProduct | hgnc.symbol:IL10 | |
IFNA | GeneProduct | hgnc.symbol:IFNA | |
IL9 | GeneProduct | hgnc.symbol:IL9 | |
IL18RAP | GeneProduct | hgnc.symbol:IL18RAP | |
CCL2 | GeneProduct | hgnc.symbol:CCL2 | |
IL23 | GeneProduct | hgnc.symbol:IL23 | |
TF | GeneProduct | hgnc.symbol:TF | |
IL21 | GeneProduct | hgnc.symbol:IL21 | |
CFB | GeneProduct | ensembl:ENSG00000243649 | |
CCL3 | GeneProduct | hgnc.symbol:CCL3 | |
IL4 | GeneProduct | hgnc.symbol:IL4 | |
RRM2 | GeneProduct | hgnc.symbol:RRM2 | |
CCL2 | GeneProduct | hgnc.symbol:CCL2 | |
APOD | GeneProduct | hgnc.symbol:APOD | |
CTSB | GeneProduct | hgnc.symbol:CTSB | |
IGLC2 | GeneProduct | ncbigene:3538 | |
APOA1 | GeneProduct | hgnc.symbol:APOA1 | |
IL1A | GeneProduct | hgnc.symbol:IL1A | |
IGHE | GeneProduct | ncbigene:3497 | |
HLA-DRA | GeneProduct | ncbigene:3122 | |
SERPINA5 | GeneProduct | hgnc.symbol:SERPINA5 | |
CD4 | GeneProduct | ncbigene:920 | |
CD8A | GeneProduct | ncbigene:926 | |
IL10 | GeneProduct | hgnc.symbol:IL10 | |
HLA-DRB1 | GeneProduct | ncbigene:3123 | |
ALB | GeneProduct | hgnc.symbol:ALB | |
IGLL1 | GeneProduct | ncbigene:3543 | |
PRG3 | GeneProduct | ncbigene:10394 | |
CD8A | GeneProduct | ncbigene:925 | |
CRP | GeneProduct | ncbigene:1401 | |
TPO | GeneProduct | hgnc.symbol:TPO | |
MMP25 | GeneProduct | ncbigene:64386 | |
NLRP3 | GeneProduct | hgnc.symbol:NLRP3 | |
JUNB | GeneProduct | hgnc.symbol:JUNB | |
IFI6 | GeneProduct | hgnc.symbol:IFI6 | |
IFI44L | GeneProduct | hgnc.symbol:IFI44L | |
CCNB1 | GeneProduct | hgnc.symbol:CCNB1 | |
LBP | GeneProduct | ncbigene:3929 | |
HLA-DRB4 | GeneProduct | ncbigene:3126 | |
IGHG4 | GeneProduct | ncbigene:3503 | |
GP1BA | GeneProduct | hgnc.symbol:GP1BA | |
NTRK1 | GeneProduct | hgnc.symbol:NTRK1 | |
IGHG2 | GeneProduct | ncbigene:3501 | |
CTSL | GeneProduct | hgnc.symbol:CTSL | |
CD2 | GeneProduct | ncbigene:914 | |
CTSL | GeneProduct | hgnc.symbol:CTSL | |
NLRP1 | GeneProduct | ncbigene:22861 | |
HLA-DRB5 | GeneProduct | ncbigene:3127 | |
IL1B | GeneProduct | hgnc.symbol:IL1B | |
IGHG1 | GeneProduct | ncbigene:3500 | |
CD247 | GeneProduct | ncbigene:919 | |
CD3G | GeneProduct | ncbigene:917 | |
LCK | GeneProduct | ncbigene:3932 | |
CD3E | GeneProduct | ncbigene:916 | |
ZAP70 | GeneProduct | ncbigene:7535 | |
TRBC1 | GeneProduct | ncbigene:28639 | |
FYN | GeneProduct | ncbigene:2534 | |
TRAC | GeneProduct | ncbigene:28755 | |
TBK1 | GeneProduct | ncbigene:29110 | |
DDX58 | GeneProduct | hgnc.symbol:DDX58 | |
TNF | GeneProduct | hgnc.symbol:TNF | |
AGT | GeneProduct | hgnc.symbol:AGT | |
IFNA | GeneProduct | hgnc.symbol:IFNA | |
IL17A | GeneProduct | hgnc.symbol:IL17A | |
CXCL5 | GeneProduct | hgnc.symbol:CXCL5 | |
LDH | GeneProduct | hgnc.symbol:LDH | |
CRP | GeneProduct | hgnc.symbol:CRP | |
MCP1 | GeneProduct | hgnc.symbol:MCP1 | |
CXCL10 | GeneProduct | hgnc.symbol:CXCL10 | |
CXCL1 | GeneProduct | hgnc.symbol:CXCL1 | |
IL1B | GeneProduct | hgnc.symbol:IL1B | |
IL10 | GeneProduct | hgnc.symbol:IL10 | |
LDH | GeneProduct | hgnc.symbol:LDH | |
IL1A | GeneProduct | hgnc.symbol:IL1A | |
IL12A | GeneProduct | hgnc.symbol:IL12A | |
CRP | GeneProduct | hgnc.symbol:CRP | |
IL6 | GeneProduct | hgnc.symbol:IL6 | |
ALB | GeneProduct | hgnc.symbol:ALB | |
S | Protein | ncbiprotein:YP_009724390.1 | |
ACE2 | Protein | ensembl:ENSG00000130234 | |
TMPRSS2 | Protein | ncbigene:7226 | |
nsp6 | Protein | ncbiprotein:YP_009725302 | |
orf7b | Protein | ncbiprotein:YP_009725318.1 | |
orf3a | Protein | ncbiprotein:YP_009724391.1 | |
nsp10 | Protein | ncbiprotein:YP_009725306 | |
M | Protein | ncbiprotein:YP_009724393.1 | |
S | Protein | ncbiprotein:YP_009724390.1 | |
nsp2 | Protein | ncbiprotein:YP_009725298 | |
orf6 | Protein | ncbiprotein:YP_009724394.1 | |
nsp9 | Protein | ncbiprotein:YP_009725305 | |
N | Protein | ncbiprotein:YP_009724397.2 | |
orf9b | Protein | ncbiprotein:P0DTD2 | |
nsp13 | Protein | ncbiprotein:YP_009725308 | |
nsp8 | Protein | ncbiprotein:YP_009725304 | |
orf7a | Protein | ncbiprotein:YP_009724395.1 | |
orf8 | Protein | ncbiprotein:YP_009724396.1 | |
BID | Protein | ncbigene:637 | |
BID | Protein | ncbigene:637 | |
NFKB2 | Protein | ncbigene:4791 | |
TGFBR2 | Protein | hgnc.symbol:TGFBR2 | |
MAPK8 | Protein | ncbiprotein:NP_001310259.1 | |
IFN1 | Protein | uniprot:IFN1 | |
IFNB1 | Protein | uniprot:P01574 | |
MAPK1 | Protein | ncbiprotein:NP_002736.3 | |
MAPK3 | Protein | ncbiprotein:NP_002737.2 | |
PLA2G4A | Protein | ncbiprotein:NP_077734.1 | |
MAPK14 | Protein | ncbiprotein:NP_001306.1 | |
IFNB1 | Protein | uniprot:P01574 | |
SQSTM1 | Protein | ncbiprotein:NP_003891.1 | |
TAX1BP1 | Protein | ncbiprotein:TAX1BP1 | |
NBR1 | Protein | ncbiprotein:NBR1 | |
GABARAPL2 | Protein | ncbigene:11345 | |
VPS16 | Protein | ncbigene:64601 | |
VPS11 | Protein | ncbigene:55823 | |
VPS41 | Protein | ncbigene:27072 | |
VPS36 | Protein | ncbigene:51028 | |
VPS33A | Protein | ncbigene:65082 | |
RPS6KB1 | Protein | ncbiprotein:NP_003152.1 | |
MLST8 | Protein | ncbigene:64223 | |
DEPTOR | Protein | ncbigene:64798 | |
RPTOR | Protein | ncbigene:57521 | |
RHEB | Protein | ncbigene:6009 | |
ATG13 | Protein | ncbigene:9776 | |
AKT1 | Protein | uniprot:P31749 | |
TSC2 | Protein | uniprot:P31749 | |
EIF4E | Protein | hgnc.symbol:EIF4E | |
PI3K | Protein | uniprot:P31749 | |
MTOR | Protein | ncbigene:2475 | |
IKBKG | Protein | ncbigene:8517 |
References
- Activation and evasion of type I interferon responses by SARS-CoV-2. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, et al. Nat Commun [Internet]. 2020 Jul 30;11(1). Available from: http://dx.doi.org/10.1038/s41467-020-17665-9 DOI Scholia
- ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection [Internet]. Zhou L, Xu Z, Castiglione GM, Soiberman US, Eberhart CG, Duh EJ. Cold Spring Harbor Laboratory; 2020. Available from: http://dx.doi.org/10.1101/2020.05.09.086165 DOI Scholia
- Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Science. 2020 Mar 27;367(6485):1444–8. PubMed Europe PMC Scholia
- Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, Liu Y, Cao L, Wang D, Guo M, Jiang A, et al. Emerg Microbes Infect. 2020 Dec;9(1):761–70. PubMed Europe PMC Scholia
- Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19. Ouyang Y, Yin J, Wang W, Shi H, Shi Y, Xu B, et al. Clin Infect Dis. 2020 Nov 19;71(16):2052–60. PubMed Europe PMC Scholia
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al. Nature. 2020 Jul;583(7816):459–68. PubMed Europe PMC Scholia
- Cell entry mechanisms of SARS-CoV-2. Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, et al. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727–34. PubMed Europe PMC Scholia
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Møller R, et al. Cell. 2020 May 28;181(5):1036-1045.e9. PubMed Europe PMC Scholia
- Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, et al. Cell. 2020 Jul 9;182(1):59-72.e15. PubMed Europe PMC Scholia
- Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, et al. medRxiv. 2020 May 19;2020.05.18.20105171. PubMed Europe PMC Scholia
- The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Ren Y, Shu T, Wu D, Mu J, Wang C, Huang M, et al. Cell Mol Immunol. 2020 Aug;17(8):881–3. PubMed Europe PMC Scholia
- Platelet gene expression and function in patients with COVID-19. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, et al. Blood. 2020 Sep 10;136(11):1317–29. PubMed Europe PMC Scholia
- Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection. Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, et al. Cell Syst. 2020 Jul 22;11(1):11-24.e4. PubMed Europe PMC Scholia
- Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Appelberg S, Gupta S, Svensson Akusjärvi S, Ambikan AT, Mikaeloff F, Saccon E, et al. Emerg Microbes Infect. 2020 Dec;9(1):1748–60. PubMed Europe PMC Scholia
- Activation and evasion of type I interferon responses by SARS-CoV-2. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, et al. Nat Commun. 2020 Jul 30;11(1):3810. PubMed Europe PMC Scholia
- Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. Li J, Guo M, Tian X, Wang X, Yang X, Wu P, et al. Med (N Y). 2021 Jan 15;2(1):99-112.e7. PubMed Europe PMC Scholia
- Evasion of Type I Interferon by SARS-CoV-2. Xia H, Cao Z, Xie X, Zhang X, Chen JYC, Wang H, et al. Cell Rep. 2020 Oct 6;33(1):108234. PubMed Europe PMC Scholia
- ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. Miao G, Zhao H, Li Y, Ji M, Chen Y, Shi Y, et al. Dev Cell. 2021 Feb 22;56(4):427-442.e5. PubMed Europe PMC Scholia
- Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, et al. Nature. 2021 Jun;594(7862):246–52. PubMed Europe PMC Scholia