Proteasome degradation (WP302)
Rattus norvegicus
For a description of pathway objects, see the WikiPathways Legend.
Authors
Nathan Salomonis , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , and Eric WeitzActivity
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Cited In
- Microarray analyses reveal novel targets of exercise-induced stress resistance in the dorsal raphe nucleus (2013).
- Cluefish: mining the dark matter of transcriptional data series with over-representation analysis enhanced by aggregated biological prior knowledge (2025).
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
ubiquitin/proteasome degradation pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ATP | Metabolite | cas:1927-31-7 | |
| Psmb10 | GeneProduct | ensembl:ENSRNOG00000019494 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5699 |
| Uchl3 | GeneProduct | ensembl:ENSRNOG00000009530 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000118939 |
| Psma2 | GeneProduct | ensembl:ENSRNOG00000049920 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5683 |
| RT1-M6-1 | GeneProduct | ensembl:ENSRNOG00000022107 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3135 |
| Psme1 | GeneProduct | ensembl:ENSRNOG00000019041 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5720 |
| Psmb1 | GeneProduct | ensembl:ENSRNOG00000001488 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5689 |
| Psma5 | GeneProduct | ensembl:ENSRNOG00000019868 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5686 |
| RT1-M6-1 | GeneProduct | ensembl:ENSRNOG00000022107 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3133 |
| Psmd12 | GeneProduct | ensembl:ENSRNOG00000003117 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5718 |
| Psmd9 | GeneProduct | ensembl:ENSRNOG00000001339 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5715 |
| Psmc5 | GeneProduct | ensembl:ENSRNOG00000010038 | PRS6 HUMANHomology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5705 |
| Ube2b | GeneProduct | ensembl:ENSRNOG00000059348 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7320 |
| Psmb8 | GeneProduct | ensembl:ENSRNOG00000000456 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5696 |
| Psmd7 | GeneProduct | ensembl:ENSRNOG00000014097 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5713 |
| Psmb4 | GeneProduct | ensembl:ENSRNOG00000020979 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5692 |
| Ube2d3 | GeneProduct | ensembl:ENSRNOG00000013741 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7323 |
| Psmd11 | GeneProduct | ensembl:ENSRNOG00000005538 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5717 |
| Uba1 | GeneProduct | ensembl:ENSRNOG00000019164 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7317 |
| Rpn1 | GeneProduct | ensembl:ENSRNOG00000046345 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6184 |
| Psmc3 | GeneProduct | ensembl:ENSRNOG00000011414 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5702 |
| H2AFZ | GeneProduct | ensembl:ENSRNOG00000031564 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3015 |
| Psmb2 | GeneProduct | ensembl:ENSRNOG00000011463 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5690 |
| Psmb9 | GeneProduct | ensembl:ENSRNOG00000000459 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5698 |
| Ifng | GeneProduct | ensembl:ENSRNOG00000007468 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3458 |
| Psma3 | GeneProduct | ensembl:ENSRNOG00000007851 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5684 |
| Uchl1 | GeneProduct | ensembl:ENSRNOG00000002343 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000154277 |
| RT1-M6-1 | GeneProduct | ensembl:ENSRNOG00000022107 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3105 |
| RT1-M6-1 | GeneProduct | ensembl:ENSRNOG00000022107 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3134 |
| Psmd3 | GeneProduct | ensembl:ENSRNOG00000028103 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5709 |
| Psmd13 | GeneProduct | ensembl:ENSRNOG00000014109 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5719 |
| Ube2d2 | GeneProduct | ensembl:ENSRNOG00000042523 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7322 |
| Rpn2 | GeneProduct | ensembl:ENSRNOG00000007492 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6185 |
| H2afx | GeneProduct | ensembl:ENSRNOG00000010386 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3014 |
| Psmd6 | GeneProduct | ensembl:ENSRNOG00000006751 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9861 |
| Psma7 | GeneProduct | ensembl:ENSRNOG00000056853 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5688 |
| Uba7 | GeneProduct | ensembl:ENSRNOG00000029195 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7318 |
| LOC100360846 | GeneProduct | ensembl:ENSRNOG00000011827 | U13393Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5694 |
| AABR07045621.1 | GeneProduct | ensembl:ENSRNOG00000049150 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5687 |
| Psmb5 | GeneProduct | ensembl:ENSRNOG00000013386 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5693 |
| Psme3 | GeneProduct | ensembl:ENSRNOG00000051344 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10197 |
| Psmc1 | GeneProduct | ensembl:ENSRNOG00000003951 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5700 |
| Psmd5 | GeneProduct | ensembl:ENSRNOG00000018809 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5711 |
| Ube2d1 | GeneProduct | ensembl:ENSRNOG00000000611 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7321 |
| Nedd4 | GeneProduct | ensembl:ENSRNOG00000058898 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4734 |
| Psmc6 | GeneProduct | ensembl:ENSRNOG00000007203 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5706 |
| Psmc4 | GeneProduct | ensembl:ENSRNOG00000018994 | PRS6 HUMANHomology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5704 |
| Psmd4 | GeneProduct | ensembl:ENSRNOG00000021042 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5710 |
| RT1-M6-1 | GeneProduct | ensembl:ENSRNOG00000022107 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3107 |
| Psma4 | GeneProduct | ensembl:ENSRNOG00000013493 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5685 |
| Psme2 | GeneProduct | ensembl:ENSRNOG00000019246 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5721 |
| Psmb7 | GeneProduct | ensembl:ENSRNOG00000011732 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5695 |
| Psmd1 | GeneProduct | ensembl:ENSRNOG00000017730 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5707 |
| Psmc2 | GeneProduct | ensembl:ENSRNOG00000012026 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5701 |
| RT1-M6-1 | GeneProduct | ensembl:ENSRNOG00000022107 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3106 |
| Psmd2 | GeneProduct | ensembl:ENSRNOG00000001719 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5708 |
| Psmd8 | GeneProduct | ensembl:ENSRNOG00000037580 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5714 |
| Psmc5 | GeneProduct | ensembl:ENSRNOG00000010038 | Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5705 |
References
- Basic Medical Research Award. The ubiquitin system. Hershko A, Ciechanover A, Varshavsky A. Nat Med. 2000 Oct;6(10):1073–81. PubMed Europe PMC Scholia
- Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, et al. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1380–7. PubMed Europe PMC Scholia