Neurotransmitter clearance in synaptic cleft (WP3165)

Bos taurus

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Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter.
This topic will be annotated in a future release.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=112311

Authors

Martina Summer-Kutmon , Elisa Cirillo , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to the brain and nervous system signaling pathway

Participants

Label Type Compact URI Comment
AcCho Metabolite chebi:15355
Cho Metabolite chebi:15354
NAd Metabolite chebi:18357
NAd Metabolite chebi:18357
Na+ Metabolite chebi:29101
DA Metabolite chebi:18243
DA Metabolite chebi:18243
Na+ Metabolite chebi:29101
AdoMet Metabolite chebi:15414
AdoHcy Metabolite chebi:16680
CDNB Metabolite chebi:34718
O2 Metabolite chebi:15379
H2O Metabolite chebi:15377
H2O2 Metabolite chebi:16240
5HT-N-CH3 Metabolite chebi:3210
NH3 Metabolite chebi:16134
FAD [mitochondrialouter membrane] Metabolite chebi:16238
H2O Metabolite chebi:15377
O2 Metabolite chebi:15379
NH3 Metabolite chebi:16134
HCYS Metabolite chebi:17230
5HT-N-CH3 Metabolite chebi:3210
AdoMet Metabolite chebi:15414
5HT Metabolite chebi:28790
5HT Metabolite chebi:28790
Na+ Metabolite chebi:29101
Na+ Metabolite chebi:29101
HIALD Metabolite chebi:50157
NAD+ Metabolite chebi:15846
HIAA Metabolite chebi:27823
H+ Metabolite chebi:15378
NADH Metabolite chebi:16908
H2O Metabolite chebi:15377
HIALD Metabolite chebi:50157
H2O2 Metabolite chebi:16240
NH3 Metabolite chebi:16134
H2O Metabolite chebi:15377
acetate Metabolite chebi:30089
SLC22A2 Protein ensembl:ENSBTAG00000009583 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15244
SLC6A3 Protein ensembl:ENSBTAG00000015843 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q01959
COMT Protein ensembl:ENSBTAG00000019516 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21964
MAOA Protein ensembl:ENSBTAG00000016206 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21397
ALDH2 Protein ensembl:ENSBTAG00000008743 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P05091

References

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