BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation (WP3876)

Homo sapiens

This pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO1 function through B-Catenin which indirectly stimulates HPESC differentiation. DKKs and SFRPs are activated by BMP2 inhibit WNT4 and stop downstream signaling. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


AAR&Co , Friederike Ehrhart , Kristina Hanspers , Martina Summer-Kutmon , Eric Weitz , and Egon Willighagen


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Homo sapiens



Cell Type Ontology

stromal cell

Pathway Ontology

Wnt signaling pathway


Label Type Compact URI Comment
cAMP Metabolite hmdb:HMDB0000058
SFRPs GeneProduct ensembl:ENSG00000104332 Protein Family
DCN GeneProduct ensembl:ENSG00000011465
SMAD8 GeneProduct ensembl:ENSG00000120693
BMP2 GeneProduct ensembl:ENSG00000125845
DKKs GeneProduct uniprot:O94907 Protein Family
SST GeneProduct ensembl:ENSG00000157005
BCL2L11 GeneProduct ensembl:ENSG00000153094
WNT4 GeneProduct ensembl:ENSG00000162552
SMAD5 GeneProduct ensembl:ENSG00000113658
FOXO1 GeneProduct ensembl:ENSG00000150907
LEFTY2 GeneProduct ensembl:ENSG00000143768
SMAD1 GeneProduct ensembl:ENSG00000170365
B-Catenin Protein uniprot:B4DGU4


  1. WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation. Li Q, Kannan A, Das A, Demayo FJ, Hornsby PJ, Young SL, et al. Endocrinology. 2013 Jan;154(1):446–57. PubMed Europe PMC Scholia