Wnt signaling pathway and pluripotency (WP779)

Gallus gallus

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.


Kristina Hanspers , Egon Willighagen , Daniela Digles , Eric Weitz , and Lars Willighagen


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Gallus gallus



Pathway Ontology

Wnt signaling, canonical pathway


Label Type Compact URI Comment
FZD8 GeneProduct ncbigene:374059
APC GeneProduct ncbigene:415607
CTBP1 GeneProduct ncbigene:422904
MMP7 GeneProduct ncbigene:418983
CTNNB1 GeneProduct ncbigene:395964
JUN GeneProduct ncbigene:424673
FZD10_CHICK GeneProduct ensembl:ENSGALG00000002652
NP_001006325.1 GeneProduct ensembl:ENSGALG00000003247
RCJMB04_16p24 GeneProduct ncbigene:424991
PLAU GeneProduct ncbigene:396424
WNT2B GeneProduct ncbigene:374243
CREBBP GeneProduct ncbigene:416667
PPP2CA GeneProduct ncbigene:416318
PPP2CB GeneProduct ncbigene:396021
NP_989878.1 GeneProduct ensembl:ENSGALG00000006480
Q9IB43_CHICK GeneProduct ensembl:ENSGALG00000008883
RCJMB04_5a10 GeneProduct ncbigene:417430
LEF1 GeneProduct ncbigene:395865
SOX2 GeneProduct ncbigene:396105
ZBTB33 GeneProduct ncbigene:422367
RACGAP1 GeneProduct ncbigene:426884
MAPK10 GeneProduct ncbigene:422592
FZD2 GeneProduct ncbigene:374061
WNT16 GeneProduct ncbigene:427856
WNT2 GeneProduct ncbigene:417769
WNT9B GeneProduct ncbigene:771092
WNT5A GeneProduct ncbigene:395703
TCF7L1 GeneProduct ncbigene:395230
PPARD GeneProduct ncbigene:395479
EP300 GeneProduct ncbigene:418000
FBXW2 GeneProduct ncbigene:417088
NLK GeneProduct ncbigene:417669
PPM1J GeneProduct ensembl:ENSGALG00000001605
PRKCB GeneProduct ncbigene:416567
RCJMB04_12k21 GeneProduct ncbigene:423302
FOXD3_CHICK GeneProduct ensembl:ENSGALG00000012644
MYC GeneProduct ncbigene:420332
WNT6 GeneProduct ncbigene:395235
RCJMB04_2d20 GeneProduct ncbigene:419416
PAFAH1B1 GeneProduct ncbigene:374224
WNT11 GeneProduct ncbigene:395562
TP53 GeneProduct ncbigene:396200
CCND1 GeneProduct ncbigene:396341
WNT3 GeneProduct ncbigene:395396
PPP2R2B GeneProduct ncbigene:416350
MAPK9 GeneProduct ncbigene:395983
PPP2R3B GeneProduct ncbigene:418670
WNT7A GeneProduct ncbigene:374168
CTBP2 GeneProduct ncbigene:423958
PPP2R1B GeneProduct ncbigene:777130
PPP2R5E GeneProduct ncbigene:423512
PRKCZ GeneProduct ncbigene:419399
LRP6 GeneProduct ncbigene:419097
FZD4 GeneProduct ncbigene:373887
DVL3 GeneProduct ncbigene:424949
AXIN2 GeneProduct ncbigene:395152
FZD9 GeneProduct ncbigene:373886
RHOA GeneProduct ncbigene:395442
FZD6 GeneProduct ncbigene:378788
NKD1 GeneProduct ncbigene:415729
FZD7 GeneProduct ncbigene:374060
AXIN1 GeneProduct ncbigene:395786
NANOG GeneProduct ncbigene:100272166
PPP2R5C GeneProduct ncbigene:423460
GSK3B GeneProduct ncbigene:418335
WNT4 GeneProduct ncbigene:395561
RCJMB04_5f2 GeneProduct ncbigene:419523
CSNK1E GeneProduct ncbigene:378891
PPP2R2C GeneProduct ncbigene:422858
FZD3 GeneProduct ncbigene:395572
RCJMB04_21j12 GeneProduct ncbigene:428852
WNT10A GeneProduct ncbigene:429040
LDLR GeneProduct ncbigene:395103
MAP3K7 GeneProduct ncbigene:421808
WNT11 GeneProduct ncbigene:395562 Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
PRKCE GeneProduct ncbigene:421409
FZD5 GeneProduct ncbigene:374112
CCND3 GeneProduct ncbigene:419928
PPP2R3A GeneProduct ncbigene:424733
PRKCH GeneProduct ncbigene:423518
CD44 GeneProduct ncbigene:395666
WNT7B GeneProduct ncbigene:427937
WNT5B GeneProduct ncbigene:418154
FZD1 GeneProduct ncbigene:374062
PRKCD GeneProduct ncbigene:415905
PPP2R4 GeneProduct ncbigene:426329
RCJMB04_11b2 GeneProduct ncbigene:423114
CCND2 GeneProduct ncbigene:374047


  1. KEGG Pathway: hsa04310
  2. Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Sato N, Brivanlou AH. Methods Mol Biol. 2006;331:115–28. PubMed Europe PMC Scholia
  3. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia