DNA damage response (only ATM dependent) (WP710)

Homo sapiens

This is one of two pathways that deal with DNA damage. It has two central gene products (ATM and TP53) which are connected with the [[Pathway:WP707|other DNA damage response pathway]]. In this pathway there is only one source of DNA damage induction, since most DNA damage induction sources and their involvement are mentioned in the [[Pathway:WP707|first DNA damage response pathway]]. If it is not mentioned differently, the processes take place in the cell cytoplasm. The purpose of this pathway is to report more gene products and cell condition changes through the DNA damage response pathway and at the same time keep them clearly arranged. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP710 CPTAC Assay Portal]


Jonas Hummel , Alex Pico , Martina Summer-Kutmon , Jildau Bouwman , Martijn Van Iersel , Allan Kuchinsky , Christine Chichester , Zahra Roudbari , Ryan Miller , Asios Olia , Kristina Hanspers , Friederike Ehrhart , Lauren J. Dupuis , Finterly Hu , Eric Weitz , and Egon Willighagen


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Homo sapiens


CPTAC PancCanNet


Pathway Ontology

p53-dependent G1/S DNA damage checkpoint pathway p53 signaling pathway


Label Type Compact URI Comment
WNT7A GeneProduct ncbigene:7476
AKT1 GeneProduct hgnc.symbol:AKT1
BAK1 GeneProduct ensembl:ENSG00000030110
PIK3R3 GeneProduct ncbigene:8503
JUN GeneProduct ncbigene:3725
PLAU GeneProduct ncbigene:5328
ABL1 GeneProduct ensembl:ENSG00000097007
IRS1 GeneProduct ensembl:ENSG00000169047
MYC GeneProduct ncbigene:4609
RAC1 GeneProduct ncbigene:5879
CCNG2 GeneProduct ensembl:ENSG00000138764
RAC1 GeneProduct ensembl:ENSG00000136238
PIK3C2G GeneProduct ncbigene:5288
AKT2 GeneProduct hgnc.symbol:AKT2
ATM GeneProduct ensembl:ENSG00000149311
FOXO3 GeneProduct ensembl:ENSG00000118689
BCL6 GeneProduct ensembl:ENSG00000113916
CDC42 GeneProduct ensembl:ENSG00000070831
AKT3 GeneProduct hgnc.symbol:AKT3
CDKN1B GeneProduct ensembl:ENSG00000111276
NRAS GeneProduct ncbigene:4893
PIK3C3 GeneProduct ncbigene:5289
WNT11 GeneProduct ncbigene:7481
PIK3R4 GeneProduct ncbigene:30849
c-Myc GeneProduct ncbigene:4609
PIK3CA GeneProduct ncbigene:5290
DVL3 GeneProduct ncbigene:1857
BIK GeneProduct ensembl:ENSG00000100290
AXIN1 GeneProduct ncbigene:8312
MAPK2 GeneProduct ncbigene:5594
WNT16 GeneProduct ncbigene:51384
PIK3CD GeneProduct ncbigene:5293
BCL2 GeneProduct ensembl:ENSG00000171791
CAT GeneProduct ensembl:ENSG00000121691
BAX GeneProduct ensembl:ENSG00000087088
PEPCK GeneProduct ncbigene:5106
PIK3C2A GeneProduct ncbigene:5286
SMAD3 GeneProduct ensembl:ENSG00000166949
MAPK10 GeneProduct ncbigene:5602
CCND1 GeneProduct ncbigene:595
SOD2 GeneProduct ensembl:ENSG00000112096
ERBB2 GeneProduct ensembl:ENSG00000141736
BCL2L11 GeneProduct ensembl:ENSG00000153094
TGFB GeneProduct ncbigene:7040
PIK3CG GeneProduct ncbigene:5294
NFKB1 GeneProduct hgnc.symbol:NFKB1
WNT7B GeneProduct ncbigene:7477
RAC2 GeneProduct ensembl:ENSG00000128340
MAPK9 GeneProduct ncbigene:5601
MAP3K4 GeneProduct ensembl:ENSG00000085511
WNT2 GeneProduct ncbigene:7472
PDK1 GeneProduct ensembl:ENSG00000152256
WNT5B GeneProduct ncbigene:81029
MDM2 GeneProduct ensembl:ENSG00000135679
APC GeneProduct ncbigene:324
MAP3K1 GeneProduct ensembl:ENSG00000095015
PPP2R5C GeneProduct ncbigene:5527
CCND3 GeneProduct ncbigene:896
HRAS GeneProduct ncbigene:3265
FASLG GeneProduct ensembl:ENSG00000117560
GRB2 GeneProduct ensembl:ENSG00000177885
KRAS GeneProduct ncbigene:3845
PIK3R1 GeneProduct ncbigene:5295
SHC1 GeneProduct ensembl:ENSG00000160691
WNT5A GeneProduct ncbigene:7474
WNT10A GeneProduct ncbigene:80326
BBC3 GeneProduct hgnc.symbol:BBC3
PIK3CB GeneProduct ncbigene:5291
TCF-4 GeneProduct ncbigene:6934
TCF-1 GeneProduct ncbigene:6932
PMAIP1 GeneProduct ensembl:ENSG00000141682
BAD GeneProduct ensembl:ENSG00000002330
TCF-3 GeneProduct ncbigene:83439
CCND2 GeneProduct ncbigene:894
FRAT1 GeneProduct ncbigene:10023
WNT6 GeneProduct ncbigene:7475
CTNNB1 GeneProduct ncbigene:1499
PIK3R2 GeneProduct ncbigene:5296
LDLR GeneProduct ncbigene:3949
DVL1 GeneProduct ncbigene:1855
SOS1 GeneProduct ensembl:ENSG00000115904
DVL2 GeneProduct ncbigene:1856
LEF1 GeneProduct ncbigene:51176
WNT3 GeneProduct ncbigene:7473
RAC3 GeneProduct hgnc.symbol:RAC3
TP73 GeneProduct ensembl:ENSG00000078900
PPP2R5E GeneProduct ncbigene:5529
WNT1 GeneProduct ncbigene:7471
SOS2 GeneProduct ensembl:ENSG00000100485
MAP3K7 GeneProduct ensembl:ENSG00000135341
FOSL1 GeneProduct ncbigene:8061
NFKB2 GeneProduct hgnc.symbol:NFKB2
WNT2B GeneProduct ncbigene:7482
MAPK8 GeneProduct ensembl:ENSG00000107643
HMGB1 GeneProduct ensembl:ENSG00000189403
WNT4 GeneProduct ncbigene:54361
WNT3A GeneProduct ncbigene:89780
CDKN1A GeneProduct ensembl:ENSG00000124762
GSK3B GeneProduct ncbigene:2932 MOUSE:KG38 MOUSE
SCP2 GeneProduct ensembl:ENSG00000116171
RHOA GeneProduct ncbigene:387
WNT10B GeneProduct ncbigene:7480
PTEN GeneProduct ensembl:ENSG00000171862
PIK3C2B GeneProduct ncbigene:5287
MAPK9 GeneProduct ensembl:ENSG00000050748
G6PC GeneProduct ensembl:ENSG00000131482
SMAD4 GeneProduct ensembl:ENSG00000141646
CDKN2A GeneProduct hgnc.symbol:CDKN2A
PIK3R5 GeneProduct ncbigene:23533
TGFB1 GeneProduct ensembl:ENSG00000105329
TP53 GeneProduct ensembl:ENSG00000141510
MLKL GeneProduct ensembl:ENSG00000168404
INSR GeneProduct ensembl:ENSG00000171105
RBL2 GeneProduct ensembl:ENSG00000103479
APC GeneProduct ensembl:ENSG00000134982


  1. The role of BH3-only proteins in the immune system. Strasser A. Nat Rev Immunol. 2005 Mar;5(3):189–200. PubMed Europe PMC Scholia
  2. Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization. Fan HY, O’Connor A, Shitanaka M, Shimada M, Liu Z, Richards JS. Mol Endocrinol. 2010 Aug;24(8):1529–42. PubMed Europe PMC Scholia