IL-26 signaling pathways (WP5347)

Homo sapiens

A comprehensive network map of IL-26 signaling pathway


Rex D A B , Egon Willighagen , Kristina Hanspers , and Alex Pico


last edited

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Homo sapiens



Pathway Ontology

signaling pathway interleukin-6 signaling pathway


Label Type Compact URI Comment
Nos2 GeneProduct ncbigene:18126
Cd80 GeneProduct ncbigene:12519
Tnf GeneProduct ncbigene:21926
CASP3 GeneProduct ncbigene:836
cleaved CASP3 GeneProduct ncbigene:836
BAX GeneProduct ncbigene:581
IL6 GeneProduct ncbigene:3569
IL10 GeneProduct ncbigene:3586
TNF GeneProduct ncbigene:7124
MMP9 GeneProduct ncbigene:4318
ACTA2 GeneProduct ncbigene:59
IL6 GeneProduct ncbigene:3569
TNFSF11 GeneProduct ncbigene:8600
TRAP GeneProduct ncbigene:100187907
OCSTAMP GeneProduct ncbigene:74614
ATP6V0D2 GeneProduct ncbigene:245972
CTSK GeneProduct ncbigene:1513
NFATC1 GeneProduct ncbigene:4772
DCSTAMP GeneProduct ncbigene:81501
IL17A GeneProduct ncbigene:3605
RORC GeneProduct ncbigene:6097
CXCL8 GeneProduct ncbigene:3576
TNF GeneProduct ncbigene:7124
Tnf GeneProduct ncbigene:21926
Ccl20 GeneProduct ncbigene:20297
Cxcl2 GeneProduct ncbigene:20310
Csf GeneProduct ncbigene:12977
IL8 GeneProduct ncbigene:3576
IL1B GeneProduct ncbigene:3553
CCL20 GeneProduct ncbigene:6364
IL33 GeneProduct ncbigene:90865
DEFB4 GeneProduct ncbigene:1673
Il4 GeneProduct ncbigene:16189
Il13 GeneProduct ncbigene:16163
Il33 GeneProduct ncbigene:77125
Il17a GeneProduct ncbigene:16171
Ccl20 GeneProduct ncbigene:20297
SOCS3 GeneProduct ncbigene:9021
CXCL8 GeneProduct ncbigene:3576
IL1B GeneProduct ncbigene:3553
TNF GeneProduct ncbigene:7124
STAT1 GeneProduct ncbigene:6772
STAT3 GeneProduct ncbigene:6774
CSF2 GeneProduct ncbigene:1437
IL10 GeneProduct ncbigene:3586
ICAM1 GeneProduct ncbigene:3383
IL10R2 Protein uniprot:Q08334
IL20R1 Protein uniprot:Q9UHF4
JAK2 Protein ncbigene:3717
TGFB1 Protein uniprot:P01137
SMAD2 Protein uniprot:Q15796
MAPK3 Protein ncbigene:5595
MAPK1 Protein ncbigene:5594
MAPK8 Protein ncbigene:5599
MAPK14 Protein ncbigene:1432
STAT1 Protein ncbigene:6772
COX2 Protein uniprot:P00403
MMP1 Protein uniprot:P03956
NFKBIA Protein ncbigene:4792
STAT3 Protein ncbigene:6774
IL26 Protein uniprot:Q9NPH9
EPHA3 Protein uniprot:P29320
AKT1 Protein ncbigene:207
DDIT3 Protein uniprot:P35638
IL1B Protein uniprot:P01584
IL6 Protein uniprot:P05231
TNF Protein uniprot:P01375
RELA Protein uniprot:Q04206
MAPK9 Protein ncbigene:5601
Ccl3 Protein uniprot:P10855
Mpo Protein uniprot:P11247
Mmp9 Protein uniprot:P41245
Mmp2 Protein uniprot:P33434
JAK1 Protein ncbigene:3716
TYK2 Protein ncbigene:7297
IL8 Protein uniprot:P10145
MPO Protein uniprot:P05164
PIK3CA Protein ncbigene:5290
RELA Protein ncbigene:5970
Il6 Protein ncbigene:16193
Il10 Protein ncbigene:16153
IL26 Protein uniprot:Q9NPH9
JUN Protein ncbigene:3725
JUN Protein ncbigene:3725


  1. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, et al. J Biol Chem. 2004 Aug 6;279(32):33343–51. PubMed Europe PMC Scholia
  2. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Dambacher J, Beigel F, Zitzmann K, De Toni EN, Göke B, Diepolder HM, et al. Gut. 2009 Sep;58(9):1207–17. PubMed Europe PMC Scholia
  3. Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization. Che KF, Tengvall S, Levänen B, Silverpil E, Smith ME, Awad M, et al. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1022–31. PubMed Europe PMC Scholia
  4. Expression of Interleukin-26 is upregulated in inflammatory bowel disease. Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, et al. World J Gastroenterol. 2017 Aug 14;23(30):5519–29. PubMed Europe PMC Scholia
  5. Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo. Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Kumlien Georén S, et al. PLoS One. 2017 Dec 5;12(12):e0188909. PubMed Europe PMC Scholia
  6. Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis. Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, et al. J Invest Dermatol. 2020 Mar;140(3):636-644.e2. PubMed Europe PMC Scholia
  7. Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis. Lee KA, Kim KW, Kim BM, Won JY, Min HK, Lee DW, et al. Arthritis Res Ther. 2019 Dec 12;21(1):283. PubMed Europe PMC Scholia
  8. Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-β1/Smad2 signaling pathway. Zhang X, Xie X, Wang Y, Li W, Lin Z. Int J Clin Exp Pathol. 2019 Dec 1;12(12):4271–9. PubMed Europe PMC Scholia
  9. The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype. Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, et al. Int J Mol Sci. 2020 Jan 5;21(1):346. PubMed Europe PMC Scholia
  10. Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women. Louhaichi S, Mlika M, Hamdi B, Hamzaoui K, Hamzaoui A. J Asthma Allergy. 2020 Feb 3;13:95–107. PubMed Europe PMC Scholia
  11. Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway. Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, et al. Cells. 2020 Apr 10;9(4):938. PubMed Europe PMC Scholia
  12. IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, et al. Cell Death Dis. 2021 May 21;12(6):520. PubMed Europe PMC Scholia
  13. Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway. Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, et al. Cells. 2021 Sep 21;10(9):2500. PubMed Europe PMC Scholia