Thyroid stimulating hormone (TSH) signaling pathway (WP2032)

Homo sapiens

Human thyroid-stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in the regulation of the hypothalamus-pituitary-thyroid axis by stimulating production and secretion of the thyroid hormone from the thyroid gland and – on a longer time scale – growth and differentiation of thyrocytes. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules. NetPath ( is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, please cite the NetPath website until the pathway is published. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Dr. Renu Goel , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Alex Pico , Zahra Roudbari , Marianthi Kalafati , Lauren J. Dupuis , Denise Slenter , Egon Willighagen , Eric Weitz , and Johannes W. Dietrich


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Homo sapiens



Pathway Ontology

thyroid-stimulating hormone signaling pathway


Label Type Compact URI Comment
CCND3 GeneProduct ncbigene:896
CCND3 GeneProduct ncbigene:896
MAP2K1 GeneProduct ncbigene:5604
MAPK3 GeneProduct ncbigene:5595
PIK3R2 GeneProduct ncbigene:5296
BRAF GeneProduct ncbigene:673
STAT1 GeneProduct ncbigene:6772
CGA GeneProduct ncbigene:1081
RAF1 GeneProduct ncbigene:5894
SCRIB GeneProduct ncbigene:23513
HRAS GeneProduct ncbigene:3265
KCNIP3 GeneProduct ncbigene:30818
GNB1 GeneProduct ncbigene:2782
GNG2 GeneProduct ncbigene:54331
TSHB GeneProduct ncbigene:7252
TSHR GeneProduct ncbigene:7253
STAT3 GeneProduct ncbigene:6774
PDPK1 GeneProduct ncbigene:5170
PIK3CA GeneProduct ncbigene:5290
PIK3R1 GeneProduct ncbigene:5295
CDK2 GeneProduct ncbigene:1017
SRC GeneProduct ncbigene:6714
MAP2K3 GeneProduct ncbigene:5606
MAP2K6 GeneProduct ncbigene:5608
AKT1 GeneProduct ncbigene:207
PRKCZ GeneProduct ncbigene:5934
RPS6KB1 GeneProduct ncbigene:6198
MAPK1 GeneProduct ncbigene:5594
RB1 GeneProduct ncbigene:5925
CREB1 GeneProduct ncbigene:1385
PDE4D GeneProduct ncbigene:5144
GNAI1 GeneProduct ncbigene:2770
GNA13 GeneProduct ncbigene:10672
GNAI2 GeneProduct ncbigene:2771
GNA12 GeneProduct ncbigene:2768
GNAO1 GeneProduct ncbigene:2775
GNAQ GeneProduct ncbigene:2776
GNAI3 GeneProduct ncbigene:2773
MYL12B GeneProduct ncbigene:103910
RALGDS GeneProduct ncbigene:5900
GNAS GeneProduct ncbigene:2778
JAK2 GeneProduct ncbigene:3717
JAK1 GeneProduct ncbigene:3716
RPS6 GeneProduct ncbigene:6194
MTOR GeneProduct ncbigene:2475
ADCY2 GeneProduct ncbigene:108
ADCY3 GeneProduct ncbigene:109
CDK2 GeneProduct ncbigene:1017
CDK4 GeneProduct ncbigene:1019
RPS6KA1 GeneProduct ncbigene:6195
PLD1 GeneProduct ncbigene:5337
PLCB1 GeneProduct ncbigene:23236
RAP1B GeneProduct ncbigene:5908
RAP1A GeneProduct ncbigene:5906
RHOA GeneProduct ncbigene:3480
CCNE1 GeneProduct ncbigene:898
MAPK14 GeneProduct ncbigene:1432
CDKN1B GeneProduct ncbigene:1027
CCND3 GeneProduct ncbigene:896
CDK4 GeneProduct ncbigene:1019
RAP1GAP GeneProduct ncbigene:5909
APEX1 GeneProduct ncbigene:328
APEX1 GeneProduct ncbigene:328


  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia
  2. A comprehensive curated resource for follicle stimulating hormone signaling. Telikicherla D, Ambekar A, Palapetta SM, Dwivedi SB, Raju R, Sharma J, et al. BMC Res Notes. 2011 Oct 13;4:408. PubMed Europe PMC Scholia