Modulators of TCR signaling and T cell activation (WP5072)

Homo sapiens

Modulators of TCR signaling and T cell activation from a genome-wide screen, with positive regulators on the left and negative regulators on the right (known and unknown). Adapted from figure 2F from [ Shifrut et al.], and originally adapted from [ NetPath].


Kristina Hanspers


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

signaling pathway T cell receptor signaling pathway

Cell Type Ontology

T cell


Label Type Compact Identifier Comment
DAG Metabolite chebi:18035
CD5 GeneProduct ensembl:ENSG00000110448
TMEM222 GeneProduct ensembl:ENSG00000186501
GNA13 GeneProduct ensembl:ENSG00000120063
PTPN6 GeneProduct ensembl:ENSG00000111679
SOCS1 GeneProduct ensembl:ENSG00000185338
CUL5 GeneProduct ensembl:ENSG00000166266
RNF7 GeneProduct ensembl:ENSG00000114125
UBASH3A GeneProduct ensembl:ENSG00000160185
FIBP GeneProduct ensembl:ENSG00000172500
RASA2 GeneProduct ensembl:ENSG00000155903
DGKZ GeneProduct ensembl:ENSG00000149091
DGKA GeneProduct ensembl:ENSG00000065357
TCEB2 GeneProduct ensembl:ENSG00000103363
TNFAIP3 GeneProduct ensembl:ENSG00000118503
SMARCB1 GeneProduct ensembl:ENSG00000099956
CDKN1B GeneProduct ensembl:ENSG00000111276
ZFP36L1 GeneProduct ensembl:ENSG00000185650
RPRD1B GeneProduct ensembl:ENSG00000101413
PCBP2 GeneProduct ensembl:ENSG00000197111
ARIH2 GeneProduct ensembl:ENSG00000177479
MEF2D GeneProduct ensembl:ENSG00000116604
AGO1 GeneProduct ensembl:ENSG00000092847
RHOH GeneProduct ensembl:ENSG00000168421
SH2D1A GeneProduct ensembl:ENSG00000183918
NDUFB10 GeneProduct ensembl:ENSG00000140990
MAP4K1 Protein ensembl:ENSG00000104814
LCP2 Protein ensembl:ENSG00000043462
TRB BETA Protein ncbigene:6957
CBLB Protein ncbigene:868
NFKB1 Protein ensembl:ENSG00000109320
REL Protein ensembl:ENSG00000162924
RELA Protein ensembl:ENSG00000173039
CHUK Protein ensembl:ENSG00000213341
IKBKB Protein ensembl:ENSG00000104365
NFKBIA Protein ensembl:ENSG00000100906
LCK Protein ensembl:ENSG00000182866
CD247 Protein ensembl:ENSG00000198821
CARD11 Protein ensembl:ENSG00000198286
ITK Protein ensembl:ENSG00000113263
PRKCQ Protein ensembl:ENSG00000065675
CD247 Protein ensembl:ENSG00000198821
SH2B3 Protein ensembl:ENSG00000111252
CD3E Protein ncbigene:916
GRAP2 Protein ensembl:ENSG00000100351
GRB2 Protein ensembl:ENSG00000177885
CD3D Protein ensembl:ENSG00000167286
CD3E Protein ensembl:ENSG00000198851
PLCG1 Protein ensembl:ENSG00000124181
CD3G Protein ensembl:ENSG00000160654
MALT1 Protein ensembl:ENSG00000172175
BCL10 Protein ensembl:ENSG00000142867
VAV1 Protein ensembl:ENSG00000141968
PIK3R2 Protein ensembl:ENSG00000105647
LAT Protein ensembl:ENSG00000213658
PIK3R1 Protein ensembl:ENSG00000145675
TRA ALPHA Protein ncbigene:6955
CD8A Protein ensembl:ENSG00000153563
ZAP70 Protein ensembl:ENSG00000115085
CD28 Protein ensembl:ENSG00000178562
AKT1 Protein ensembl:ENSG00000142208
PDPK1 Protein ensembl:ENSG00000140992
MAP3K14 Protein ensembl:ENSG00000006062
MAP3K8 Protein ensembl:ENSG00000107968
IKBKG Protein ensembl:ENSG00000269335
TRAF6 Protein ensembl:ENSG00000175104


  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia
  2. Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, et al. Cell. 2018 Dec 13;175(7):1958-1971.e15. PubMed Europe PMC Scholia