Modulators of TCR signaling and T cell activation (WP5072)

Homo sapiens

Modulators of TCR signaling and T cell activation from a genome-wide screen, with positive regulators on the left and negative regulators on the right (known and unknown). Adapted from figure 2F from [ Shifrut et al.], and originally adapted from [ NetPath].


Kristina Hanspers


last edited

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Homo sapiens



Pathway Ontology

signaling pathway T cell receptor signaling pathway

Cell Type Ontology

T cell


Label Type Compact URI Comment
DAG Metabolite chebi:18035
CD5 GeneProduct ensembl:ENSG00000110448
TMEM222 GeneProduct ensembl:ENSG00000186501
GNA13 GeneProduct ensembl:ENSG00000120063
PTPN6 GeneProduct ensembl:ENSG00000111679
SOCS1 GeneProduct ensembl:ENSG00000185338
CUL5 GeneProduct ensembl:ENSG00000166266
RNF7 GeneProduct ensembl:ENSG00000114125
UBASH3A GeneProduct ensembl:ENSG00000160185
FIBP GeneProduct ensembl:ENSG00000172500
RASA2 GeneProduct ensembl:ENSG00000155903
DGKZ GeneProduct ensembl:ENSG00000149091
DGKA GeneProduct ensembl:ENSG00000065357
TCEB2 GeneProduct ensembl:ENSG00000103363
TNFAIP3 GeneProduct ensembl:ENSG00000118503
SMARCB1 GeneProduct ensembl:ENSG00000099956
CDKN1B GeneProduct ensembl:ENSG00000111276
ZFP36L1 GeneProduct ensembl:ENSG00000185650
RPRD1B GeneProduct ensembl:ENSG00000101413
PCBP2 GeneProduct ensembl:ENSG00000197111
ARIH2 GeneProduct ensembl:ENSG00000177479
MEF2D GeneProduct ensembl:ENSG00000116604
AGO1 GeneProduct ensembl:ENSG00000092847
RHOH GeneProduct ensembl:ENSG00000168421
SH2D1A GeneProduct ensembl:ENSG00000183918
NDUFB10 GeneProduct ensembl:ENSG00000140990
MAP4K1 Protein ensembl:ENSG00000104814
LCP2 Protein ensembl:ENSG00000043462
TRB BETA Protein ncbigene:6957
CBLB Protein ncbigene:868
NFKB1 Protein ensembl:ENSG00000109320
REL Protein ensembl:ENSG00000162924
RELA Protein ensembl:ENSG00000173039
CHUK Protein ensembl:ENSG00000213341
IKBKB Protein ensembl:ENSG00000104365
NFKBIA Protein ensembl:ENSG00000100906
LCK Protein ensembl:ENSG00000182866
CD247 Protein ensembl:ENSG00000198821
CARD11 Protein ensembl:ENSG00000198286
ITK Protein ensembl:ENSG00000113263
PRKCQ Protein ensembl:ENSG00000065675
CD247 Protein ensembl:ENSG00000198821
SH2B3 Protein ensembl:ENSG00000111252
CD3E Protein ncbigene:916
GRAP2 Protein ensembl:ENSG00000100351
GRB2 Protein ensembl:ENSG00000177885
CD3D Protein ensembl:ENSG00000167286
CD3E Protein ensembl:ENSG00000198851
PLCG1 Protein ensembl:ENSG00000124181
CD3G Protein ensembl:ENSG00000160654
MALT1 Protein ensembl:ENSG00000172175
BCL10 Protein ensembl:ENSG00000142867
VAV1 Protein ensembl:ENSG00000141968
PIK3R2 Protein ensembl:ENSG00000105647
LAT Protein ensembl:ENSG00000213658
PIK3R1 Protein ensembl:ENSG00000145675
TRA ALPHA Protein ncbigene:6955
CD8A Protein ensembl:ENSG00000153563
ZAP70 Protein ensembl:ENSG00000115085
CD28 Protein ensembl:ENSG00000178562
AKT1 Protein ensembl:ENSG00000142208
PDPK1 Protein ensembl:ENSG00000140992
MAP3K14 Protein ensembl:ENSG00000006062
MAP3K8 Protein ensembl:ENSG00000107968
IKBKG Protein ensembl:ENSG00000269335
TRAF6 Protein ensembl:ENSG00000175104


  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia
  2. Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, et al. Cell. 2018 Dec 13;175(7):1958-1971.e15. PubMed Europe PMC Scholia