Monoamine GPCRs (WP1389)

Danio rerio

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [ Monoamine neurotransmitters]


Kristina Hanspers , Egon Willighagen , Martina Summer-Kutmon , Ado , and Eric Weitz


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Danio rerio



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite pubchem.compound:9308
hrh1 GeneProduct ncbigene:735302
adra2c GeneProduct ncbigene:266752
htr4 GeneProduct ensembl:ENSDARG00000061940
drd3 GeneProduct ncbigene:282554
hrh2 GeneProduct ensembl:ENSDARG00000057479
chrm3 GeneProduct ncbigene:571679
adra1a GeneProduct ensembl:ENSDARG00000028725
drd5 GeneProduct ensembl:ENSDARG00000090669
adrb3a GeneProduct ncbigene:558248
adra1b GeneProduct ensembl:ENSDARG00000011317
chrm2a GeneProduct ncbigene:352938
htr6 GeneProduct ensembl:ENSDARG00000016095
htr1d GeneProduct ensembl:ENSDARG00000054124
chrm3b GeneProduct ncbigene:100149598
htr1e GeneProduct ensembl:ENSDARG00000011468
htr7 GeneProduct ensembl:ENSDARG00000056949
chrm4a GeneProduct ncbigene:100150701
chrm5a GeneProduct ncbigene:553978
adra2a GeneProduct ncbigene:266750
htr2a GeneProduct ensembl:ENSDARG00000057029
htr1f GeneProduct ensembl:ENSDARG00000002773
drd1 GeneProduct ncbigene:568126
htr5a GeneProduct ncbigene:100038775
adrb1 GeneProduct ncbigene:557194
adra2b GeneProduct ncbigene:266751
htr2b GeneProduct ensembl:ENSDARG00000070940
htr1aa GeneProduct ncbigene:100001828
adra1d GeneProduct ensembl:ENSDARG00000024101
htr1b GeneProduct ncbigene:561647