Insulin signaling (WP481)

Homo sapiens

Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentiation. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Mary-Elizabeth Patti , Thomas Kelder , Andra Waagmeester , Kristina Hanspers , Martina Summer-Kutmon , Martijn Van Iersel , Federica Eduati , Alex Pico , Congcong Yin , and Eric Weitz


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Homo sapiens



Pathway Ontology

insulin signaling pathway


Label Type Compact URI Comment
STXBP2 GeneProduct ncbigene:6813
PIK3CD GeneProduct ncbigene:5293
PIK3C3 GeneProduct ncbigene:5289
PSCD3 GeneProduct ncbigene:9265
PTPRF GeneProduct ncbigene:5792
RAC1 GeneProduct ncbigene:5879
GSK3B GeneProduct ncbigene:2932
PTP GeneProduct ncbigene:5967
MINK1 GeneProduct ncbigene:50488
GRB2 GeneProduct ncbigene:2885
SHC3 GeneProduct ncbigene:53358
IRS1 GeneProduct ncbigene:3667
SLC2A1 GeneProduct ncbigene:6513
RPS6KA4 GeneProduct ncbigene:8986
IKBKB GeneProduct ncbigene:3551
MAP4K4 GeneProduct ncbigene:9448
SOCS3 GeneProduct ncbigene:9021
PRKCH GeneProduct ncbigene:5583
KIF5B GeneProduct ncbigene:3799
IRS1/2 GeneProduct ncbigene:3667
EHD2 GeneProduct ncbigene:30846
ARF6 GeneProduct ncbigene:382
GYG GeneProduct ncbigene:2992
AKT2 GeneProduct ncbigene:208
SRF GeneProduct ncbigene:6722
MAP3K2 GeneProduct ncbigene:10746
RAB4A GeneProduct ncbigene:5867
PRKCD GeneProduct ncbigene:5580
AKT1 GeneProduct ncbigene:207
CAP1 GeneProduct ncbigene:10487
RHEB GeneProduct ncbigene:6009
PFKM GeneProduct ncbigene:5213
STXBP1 GeneProduct ncbigene:6812
PIK3R3 GeneProduct ncbigene:8503
MAPK12 GeneProduct ncbigene:6300
PIK3R1 GeneProduct ncbigene:5295
MAP3K5 GeneProduct ncbigene:4217
IRS2 GeneProduct ncbigene:8660
PIK3C2G GeneProduct ncbigene:5288
PIK3R2 GeneProduct ncbigene:5296
MAPK10 GeneProduct ncbigene:5602
MAP3K3 GeneProduct ncbigene:4215
MAP4K1 GeneProduct ncbigene:11184
MAPK3 GeneProduct ncbigene:5595
RPS6KA3 GeneProduct ncbigene:6197
PTEN GeneProduct ncbigene:5728
ELK1 GeneProduct ncbigene:2002
SHC1 GeneProduct ncbigene:6464
CRK GeneProduct ncbigene:1398
TRIB3 GeneProduct ncbigene:57761
STXBP4 GeneProduct ncbigene:252983
RPS6KA6 GeneProduct ncbigene:27330
INSR GeneProduct ncbigene:3643
XBP1 GeneProduct ncbigene:7494
FOXO1A GeneProduct ncbigene:2308
EIF4EBP1 GeneProduct ncbigene:1978
TBC1D4 GeneProduct ncbigene:9882
PRKCB1 GeneProduct ncbigene:5579
MAP2K7 GeneProduct ncbigene:5609
RPS6KB2 GeneProduct ncbigene:6199
SOS1 GeneProduct ncbigene:6654
RAC2 GeneProduct ncbigene:5880
FOS GeneProduct ncbigene:2353
PIK3CG GeneProduct ncbigene:5294
RRAD GeneProduct ncbigene:6236
PIK3 GeneProduct ensembl:ENSG00000121879
IRS4 GeneProduct ncbigene:8471
SGKL GeneProduct ncbigene:23678
APS GeneProduct ncbigene:10603
MAPK13 GeneProduct ncbigene:5603
GYS1 GeneProduct ncbigene:2997
TSC2 GeneProduct ncbigene:7249
PIK3CB GeneProduct ncbigene:5291
EHD1 GeneProduct ncbigene:10938
MAP3K1 GeneProduct ncbigene:4214
MAP4K3 GeneProduct ncbigene:8491
ENPP1 GeneProduct ncbigene:5167
MAP2K6 GeneProduct ncbigene:5608
SNX26 GeneProduct ncbigene:115703
SLC2A4 GeneProduct ncbigene:6517
MAP3K8 GeneProduct ncbigene:1326
PFKL GeneProduct ncbigene:5211
TSC1 GeneProduct ncbigene:7248
MAP3K12 GeneProduct ncbigene:7786
RPS6KA5 GeneProduct ncbigene:9252
STX4A GeneProduct ncbigene:6810
IGF1R GeneProduct ncbigene:3480
PRKCZ GeneProduct ncbigene:5590
SNAP25 GeneProduct ncbigene:6616
MAP2K4 GeneProduct ncbigene:6416
GRB14 GeneProduct ncbigene:2888
PRKCQ GeneProduct ncbigene:5588
RPS6KA1 GeneProduct ncbigene:6195
MAPK7 GeneProduct ncbigene:5598
RPS6KA2 GeneProduct ncbigene:6196
MAPK14 GeneProduct ncbigene:1432
RPS6KB1 GeneProduct ncbigene:6198
RHOQ GeneProduct ncbigene:23433
MAP3K11 GeneProduct ncbigene:4296
PRKAA2 GeneProduct ncbigene:5563
SNAP23 GeneProduct ncbigene:8773
PTPN1 GeneProduct ncbigene:5770
MAPK8 GeneProduct ncbigene:5599
INPPL1 GeneProduct ncbigene:3636
CBLB GeneProduct ncbigene:868
MAP3K7 GeneProduct ncbigene:6885
STXBP3 GeneProduct ncbigene:6814
INPP4A GeneProduct ncbigene:3631
SGK GeneProduct ncbigene:6446
CBL GeneProduct ncbigene:867
PIK3R4 GeneProduct ncbigene:30849
MAPK11 GeneProduct ncbigene:5600
MAPK9 GeneProduct ncbigene:5601
PTPN11 GeneProduct ncbigene:5781
GYS2 GeneProduct ncbigene:2998
JUN GeneProduct ncbigene:3725
SOCS1 GeneProduct ncbigene:8651
MAPK6 GeneProduct ncbigene:5597
EIF4E GeneProduct ncbigene:1977
SHC2 GeneProduct ncbigene:25759
FLOT2 GeneProduct ncbigene:2319
CBLC GeneProduct ncbigene:23624
MYO1C GeneProduct ncbigene:4641
GAB1 GeneProduct ncbigene:2549
RHOJ GeneProduct ncbigene:57381
GSK3A GeneProduct ncbigene:2931
PRKCI GeneProduct ncbigene:5584
PRKAA1 GeneProduct ncbigene:5562
SORBS1 GeneProduct ncbigene:10580
SOS2 GeneProduct ncbigene:6655
MAP3K13 GeneProduct ncbigene:9175
PPP1R3A GeneProduct ncbigene:5506
RAF1 GeneProduct ncbigene:5894
ARF1 GeneProduct ncbigene:375
FRAP1 GeneProduct ncbigene:2475
PRKCA GeneProduct ncbigene:5578
LIPE GeneProduct ncbigene:3991
MAP2K3 GeneProduct ncbigene:5606
MAPK4 GeneProduct ncbigene:5596
MAP4K2 GeneProduct ncbigene:5871
PDPK1 GeneProduct ncbigene:5170
HRAS GeneProduct ncbigene:3265
RAPGEF1 GeneProduct ncbigene:2889
FOXO3A GeneProduct ncbigene:2309
MAP2K5 GeneProduct ncbigene:5607
GRB10 GeneProduct ncbigene:2887
EGR1 GeneProduct ncbigene:1958
MAP3K10 GeneProduct ncbigene:4294
VAMP2 GeneProduct ncbigene:6844
PIK3C2A GeneProduct ncbigene:5286
MAPK1 GeneProduct ncbigene:5594
FLOT1 GeneProduct ncbigene:10211
PIK3CA GeneProduct ncbigene:5290
MAP2K1 GeneProduct ncbigene:5604
MAP3K6 GeneProduct ncbigene:9064
SGK2 GeneProduct ncbigene:10110
MAP3K4 GeneProduct ncbigene:4216
MAP3K9 GeneProduct ncbigene:4293
KIF3A GeneProduct ncbigene:11127
MAP4K5 GeneProduct ncbigene:11183
MAP2K2 GeneProduct ncbigene:5605
MAPK8 GeneProduct ncbigene:5599
MAP3K14 GeneProduct ncbigene:9020


  1. A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation. Quon MJ, Campfield LA. J Theor Biol. 1991 May 7;150(1):93–107. PubMed Europe PMC Scholia
  2. Insulin signalling. Bevan P. J Cell Sci. 2001 Apr;114(Pt 8):1429–30. PubMed Europe PMC Scholia
  3. Insulin signalling and the regulation of glucose and lipid metabolism. Saltiel AR, Kahn CR. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia