Estrogen signaling pathway (WP712)

Homo sapiens

Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Laura Van Zon , Kristina Hanspers , Chun Chen , Jildau Bouwman , Alex Pico , Lauren J. Dupuis , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

estrogen signaling pathway


Label Type Compact URI Comment
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Estradiol Metabolite hmdb:HMDB0000151
Growth factors Metabolite hmdb:HMDB0000151
Cyclic AMP Metabolite hmdb:HMDB0000058
C-FOS GeneProduct ncbigene:2353
SP1 GeneProduct ncbigene:6667
ERE GeneProduct ncbigene:2099
ER-AF1 GeneProduct ncbigene:2099
ELK GeneProduct ncbigene:2002
ERK 1/2 GeneProduct ensembl:ENSG00000100030
ER GeneProduct ncbigene:2099
ER-AF2 GeneProduct ncbigene:2099
GPR30 GeneProduct ncbigene:2852
c-Jun GeneProduct ncbigene:3725
PI3K GeneProduct ncbigene:5290
NFKB GeneProduct ncbigene:4790
Non-ERE GeneProduct ncbigene:2099
BCL2 apoptotic switch GeneProduct ncbigene:596
GFRs GeneProduct ncbigene:2099
GNGT1 GeneProduct ncbigene:2792
GNB1 GeneProduct ncbigene:2782
PKB/Akt GeneProduct ncbigene:207
CREB GeneProduct ncbigene:1385
MAPKKK GeneProduct ncbigene:673
JNKs GeneProduct ncbigene:5601
ER GeneProduct ncbigene:2099
GSA GeneProduct ncbigene:2778
p38 GeneProduct ncbigene:1432
MAPKK GeneProduct ensembl:ENSG00000169032
PKACA GeneProduct ncbigene:5566
NFKB GeneProduct ncbigene:4790
CREB GeneProduct ncbigene:1385
CHUK GeneProduct ncbigene:1147
ER GeneProduct ncbigene:2099
TF GeneProduct ncbigene:2099
IKBKB GeneProduct ncbigene:3551
IKBKG GeneProduct ncbigene:8517


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  2. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
  3. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia