Hunger and satiety (WP5445)

Homo sapiens

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Effect of gut hormones on brain signaling that controls food intake. Based on Figure 1 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959457/.

Authors

Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

ghrelin system pathway signaling pathway melanocortin system pathway

Cell Type Ontology

stomach neuroendocrine cell type L enteroendocrine cell ghrelin secreting cell fat cell enterocyte neuron

Participants
Query Drugst.One

Label Type Compact URI Comment
MC4R GeneProduct ensembl:ENSG00000166603
POMC GeneProduct ensembl:ENSG00000115138
NPY GeneProduct ensembl:ENSG00000122585
AGRP GeneProduct ensembl:ENSG00000159723
LEP GeneProduct ensembl:ENSG00000174697
GHRL GeneProduct ensembl:ENSG00000157017
GCG GeneProduct ensembl:ENSG00000115263
PYY GeneProduct ensembl:ENSG00000131096
Leptin Protein uniprot:P41159
GLP-1 Protein :https://www.wikidata.org/wiki/Q424611
Ghrelin Protein uniprot:Q5Y392

References

  1. Hormonal Gut-Brain Signaling for the Treatment of Obesity. Roh E, Choi KM. Int J Mol Sci. 2023 Feb 8;24(4):3384. PubMed Europe PMC Scholia