Neural crest cell migration in cancer (WP4565)

Homo sapiens

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Neural crest cells migrate and invade as part of normal development, but also as part of neuroblastoma metastasis in cancer. Many of the same growth factors, receptors and signaling pathways are involved. The participation of NTRK2 (TrkB), KIDINS220, and SORT1 (Sortilin) appear to be unique to the cancer signaling case, as well as the role for the intracellular domain fragment of NGFR (NGFR-ICD or p75ICD).

Authors

Alex Pico , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

signaling pathway brain-derived neurotrophic factor signaling pathway cancer pathway

Disease Ontology

neuroblastoma cancer

Cell Type Ontology

migratory neural crest cell

Participants
Query Drugst.One

Label Type Compact URI Comment
AKT2 GeneProduct ncbigene:208 AKT
AKT3 GeneProduct ncbigene:10000 AKT
CDH11 GeneProduct ncbigene:1009 Cadherin
NGEF GeneProduct ncbigene:25791
FOS GeneProduct ncbigene:2353 AP-1
EPHB1 GeneProduct ncbigene:2047 MMP
MMP9 GeneProduct ncbigene:4318 MMP
MMP2 GeneProduct ncbigene:4313 MMP2
PIK3CA GeneProduct ncbigene:5290 PI3K
PIK3CB GeneProduct ncbigene:5291 PI3K
PIK3CD GeneProduct ncbigene:5293 PI3K
PIK3R3 GeneProduct ncbigene:8503 PI3K
PIK3R4 GeneProduct ncbigene:30849 PI3K
PIK3R5 GeneProduct ncbigene:23533 PI3K
PIK3R6 GeneProduct ncbigene:146850 PI3K
TIAM1 GeneProduct ncbigene:7074 Tiam
TRIO GeneProduct ncbigene:7204 TRIO
NTRK2 GeneProduct ncbigene:4915
MMP8 GeneProduct ncbigene:4317 MMP
TWIST1 GeneProduct ncbigene:7291 Twist1,
PIK3CG GeneProduct ncbigene:5294 PI3K
ARF1 GeneProduct ncbigene:375
RAC1 GeneProduct ncbigene:5879 MMP
AKT1 GeneProduct ncbigene:207 AKT
KIDINS220 GeneProduct ncbigene:57498
BDNF GeneProduct ncbigene:627 BDNF
F2RL2 GeneProduct ncbigene:2151 MMP
JUN GeneProduct ncbigene:3725 JUN/AP
RHOA GeneProduct ncbigene:387 RhoA
STAT3 GeneProduct ncbigene:6774 STAT3
CDH11 GeneProduct ncbigene:1009 Cadherin
AKT3 GeneProduct ncbigene:10000 AKT
AKT1 GeneProduct ncbigene:207 AKT
AKT2 GeneProduct ncbigene:208 AKT
NGFR GeneProduct ncbigene:4804
NGFR GeneProduct ncbigene:4804 p75(NTR)
EPHB2 GeneProduct ncbigene:2048 MMP
EPHB3 GeneProduct ncbigene:2049 MMP
EPHB4 GeneProduct ncbigene:2050 MMP
EPHB6 GeneProduct ncbigene:2051 MMP
BDNF GeneProduct ncbigene:627 BDNF
STAT3 GeneProduct ncbigene:6774 STAT3
MMP2 GeneProduct ncbigene:4313 MMP2
TWIST1 GeneProduct ncbigene:7291 Twist1,
MMP9 GeneProduct ncbigene:4318 MMP
RAC1 GeneProduct ncbigene:5879
PAK2 GeneProduct ncbigene:5062
PAK3 GeneProduct ncbigene:5063
PAK4 GeneProduct ncbigene:10298
PAK5 GeneProduct ncbigene:57144
PAK6 GeneProduct ncbigene:56924
RAC1 GeneProduct ncbigene:5879
PAK1 GeneProduct ncbigene:5058
NGFR GeneProduct ncbigene:4804
proBDNF GeneProduct ncbigene:627 BDNF
NTRK2 GeneProduct ncbigene:4915
NTRK2 GeneProduct ncbigene:4915
SORT1 GeneProduct ncbigene:6272
NGFR-ICD GeneProduct ncbigene:4804

References

  1. From Neural Crest Development to Cancer and Vice Versa: How p75NTR and (Pro)neurotrophins Could Act on Cell Migration and Invasion? Wislet S, Vandervelden G, Rogister B. Front Mol Neurosci. 2018 Aug 23;11:244. PubMed Europe PMC Scholia