Wnt signaling pathway (WP1349)

Danio rerio

Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: [http://www.genome.jp/kegg/pathway/hsa/hsa04310.html KEGG].


Thomas Kelder , Daniela Digles , Egon Willighagen , and Eric Weitz


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Danio rerio



Pathway Ontology

Wnt signaling pathway


Label Type Compact URI Comment
LOC100149082 GeneProduct ncbigene:100149082
zgc:153713 GeneProduct ncbigene:751630
rac1 GeneProduct ncbigene:327204
prkcb1 GeneProduct ncbigene:393953
zgc:172124 GeneProduct ncbigene:100144561
gsk3b GeneProduct ncbigene:30654 MOUSE:KG38 MOUSE
APC GeneProduct ncbigene:386762
wnt3l GeneProduct ncbigene:60632
fzd3 GeneProduct ncbigene:565921
LOC100149273 GeneProduct ncbigene:100149273
csnk1da GeneProduct ncbigene:322106
ccnd1 GeneProduct ncbigene:30222
ldlr GeneProduct ncbigene:387529
LOC557123 GeneProduct ncbigene:557123
wnt7a GeneProduct ncbigene:565714
wnt11r GeneProduct ncbigene:30283
wnt1 GeneProduct ncbigene:30128
LOC100149498 GeneProduct ncbigene:100149498
jun GeneProduct ncbigene:335916
FZD10 GeneProduct ncbigene:30366
ppp2r5c GeneProduct ncbigene:557208
wnt5b GeneProduct ncbigene:30105
ctnnb1 GeneProduct ncbigene:30265
wnt2b GeneProduct ncbigene:359837
prkce GeneProduct ncbigene:100005075
wnt2bb GeneProduct ncbigene:556087
LOC100003514 GeneProduct ncbigene:100003514
pafah1b1b GeneProduct ncbigene:394247
dvl2 GeneProduct ncbigene:323630
DKEY-31M21.2 GeneProduct ncbigene:561831
wnt5a GeneProduct ncbigene:568191
FZD1 GeneProduct ncbigene:30365
wnt16 GeneProduct ncbigene:791563
zgc:65879 GeneProduct ncbigene:393533
ppp2r5eb GeneProduct ncbigene:373878
wnt3 GeneProduct ncbigene:569420
axin1 GeneProduct ncbigene:57931
wnt10b GeneProduct ncbigene:30308
PRKCQ GeneProduct ncbigene:555521
fzd8c GeneProduct ncbigene:30364
wnt7bb GeneProduct ncbigene:100148840
LOC560032 GeneProduct ncbigene:560032
prkci GeneProduct ncbigene:117507
wnt10a GeneProduct ncbigene:30171
fosl1 GeneProduct ncbigene:564241
mapk10 GeneProduct ncbigene:569698
prkcz GeneProduct ncbigene:555737
zgc:162280 GeneProduct ncbigene:799608
FZD9 GeneProduct ncbigene:58023
fbxw2 GeneProduct ncbigene:553942
PRKCD GeneProduct ncbigene:334571
TCF-1/LEF GeneProduct ensembl:ENSDARG00000031894
wnt16 GeneProduct ncbigene:791563
fzd2 GeneProduct ncbigene:30370


  1. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia