Regulation of actin cytoskeleton (WP51)

Homo sapiens

A cytoskeleton is a complex, dynamic network of interlinking protein filaments that extends from the cell nucleus to the cell membrane. Actin filaments, composed of the abundant actin protein, are a main component of the cytoskeleton, playing a key role muscle contraction. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Alex Pico , Kristina Hanspers , Diana Garcia , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , Zahra Roudbari , Finterly Hu , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

regulatory pathway cell adhesion signaling pathway


Label Type Compact URI Comment
PIP2 Metabolite kegg.compound:C04637
Bradykinin Metabolite cas:58-82-2
Acetylcholine Metabolite cas:51-84-3
LPS Metabolite kegg.compound:C00338
PIP3 Metabolite kegg.compound:C05981
PIP2 Metabolite kegg.compound:C04637
DIAP3 GeneProduct ncbigene:81624
PIP5K2B GeneProduct ncbigene:8396
MAPK1 GeneProduct ncbigene:5594
C3orf10 GeneProduct ncbigene:55845
CHRM3 GeneProduct ncbigene:1131
PIP5K1B GeneProduct ncbigene:8395
GSN GeneProduct ncbigene:2934
SSH1 GeneProduct ncbigene:54434
PAK1 GeneProduct ncbigene:5058
PFN1 GeneProduct ncbigene:5216
PIK3C3 GeneProduct ncbigene:5289
FGF5 GeneProduct ncbigene:2250
PDGFA GeneProduct ncbigene:5154
FGD1 GeneProduct ncbigene:2245
PIK3R5 GeneProduct ncbigene:23533
RAC1P4 GeneProduct ncbigene:286472
SOS2 GeneProduct ncbigene:6655
BAIAP2 GeneProduct ncbigene:10458
IQGAP1 GeneProduct ncbigene:8826
VCL GeneProduct ncbigene:7414
FGF10 GeneProduct ncbigene:2255
ARHGEF1 GeneProduct ncbigene:9138
ARHGEF7 GeneProduct ncbigene:8874
GNA13 GeneProduct ncbigene:10672
RDX GeneProduct ncbigene:5962
MYH10 GeneProduct ncbigene:4628
ABI2 GeneProduct ncbigene:10152
PFN1 GeneProduct ncbigene:5216
CHRM2 GeneProduct ncbigene:1129
CHRM1 GeneProduct ncbigene:1128
Pik3c2b GeneProduct ncbigene:5287
FGF9 GeneProduct ncbigene:2254
EGFR GeneProduct ncbigene:1956
VCL GeneProduct ncbigene:7414
ENAH GeneProduct ncbigene:55740
SSH2 GeneProduct ncbigene:85464
GRLF1 GeneProduct ncbigene:2909
RAC3 GeneProduct ncbigene:5881
WASF2 GeneProduct ncbigene:10163
PAK7 GeneProduct ncbigene:57144
PIP5KL1 GeneProduct ncbigene:138429
MRAS GeneProduct ncbigene:22808
MAP2K1 GeneProduct ncbigene:5604
LIMK1 GeneProduct ncbigene:3984
BDKRB1 GeneProduct ncbigene:623
FGF7 GeneProduct ncbigene:2252
VIL1 GeneProduct ncbigene:7429
GNA12 GeneProduct ncbigene:2768
NCKAP1 GeneProduct ncbigene:10787
FGF14 GeneProduct ncbigene:2259
ACTB GeneProduct ncbigene:60
PIK3R2 GeneProduct ncbigene:5296
RAC1P2 GeneProduct ncbigene:442775
PAK2 GeneProduct ncbigene:5062
FGFR4 GeneProduct ncbigene:2264
FGF3 GeneProduct ncbigene:2248
CHRM5 GeneProduct ncbigene:1133
FGF12 GeneProduct ncbigene:2257
CDC42 GeneProduct ncbigene:998
TMSB4X GeneProduct ncbigene:7114
PIK3C2G GeneProduct ncbigene:5288
EGF GeneProduct ncbigene:1950
ARHGEF4 GeneProduct ncbigene:50649
BCAR1 GeneProduct ncbigene:9564
MYLK GeneProduct ncbigene:4638
SSH3 GeneProduct ncbigene:54961
ACTB GeneProduct ncbigene:60
FGF4 GeneProduct ncbigene:2249
PIK3R1 GeneProduct ncbigene:5295
PAK3 GeneProduct ncbigene:5063
DOCK1 GeneProduct ncbigene:1793
CHRM4 GeneProduct ncbigene:1132
CFL2 GeneProduct ncbigene:1073
CD14 GeneProduct ncbigene:929
PDGFRB GeneProduct ncbigene:5159
ARPC5 GeneProduct ncbigene:10092
PIK3CA GeneProduct ncbigene:5290
PTK2 GeneProduct ncbigene:5747
FGF20 GeneProduct ncbigene:26281
FGF17 GeneProduct ncbigene:8822
ARPC5 GeneProduct ncbigene:10092
RHOA GeneProduct ncbigene:387
ACTB GeneProduct ncbigene:60
SLC9A1 GeneProduct ncbigene:6548
FGFR3 GeneProduct ncbigene:2261
PIK3C2A GeneProduct ncbigene:5286
FGF23 GeneProduct ncbigene:8074
PIK3CB GeneProduct ncbigene:5291
BDKRB2 GeneProduct ncbigene:624
ROCK2 GeneProduct ncbigene:9475
FGF15/19 GeneProduct ncbigene:9965
FGF18 GeneProduct ncbigene:8817
PIP5K2A GeneProduct ncbigene:5305
FGF21 GeneProduct ncbigene:26291
NRAS GeneProduct ncbigene:4893
FGF2 GeneProduct ncbigene:2247
PIK3R3 GeneProduct ncbigene:8503
VIL2 GeneProduct ncbigene:7430
ROCK1 GeneProduct ncbigene:6093
ACTG1 GeneProduct ncbigene:71
FGF22 GeneProduct ncbigene:27006
FN1 GeneProduct ncbigene:2335
FGF16 GeneProduct ncbigene:8823
PIK3CG GeneProduct ncbigene:5294
ARHGEF6 GeneProduct ncbigene:9459
MYL1 GeneProduct ncbigene:4632
RAC1 GeneProduct ncbigene:5879
BRAF GeneProduct ncbigene:673
PPP1R12A GeneProduct ncbigene:4659
WAS GeneProduct ncbigene:7454
RRAS2 GeneProduct ncbigene:22800
PIK3R4 GeneProduct ncbigene:30849
BAIAP2 GeneProduct ncbigene:10458
RRAS GeneProduct ncbigene:6237
ACTG1 GeneProduct ncbigene:71
APC GeneProduct ncbigene:324
C11orf13 GeneProduct ncbigene:8045
PDGFRA GeneProduct ncbigene:5156
KRAS GeneProduct ncbigene:3845
FGF13 GeneProduct ncbigene:2258
PIP5K1A GeneProduct ncbigene:8394
WASF1 GeneProduct ncbigene:8936
PAK4 GeneProduct ncbigene:10298
ACTN1 GeneProduct ncbigene:87
GNG12 GeneProduct ncbigene:55970
DIAP1 GeneProduct ncbigene:1729
PIP5K1C GeneProduct ncbigene:23396
SOS1 GeneProduct ncbigene:6654
MSN GeneProduct ncbigene:4478
CRK GeneProduct ncbigene:1398
ITGA1 GeneProduct ncbigene:3672
RAF1 GeneProduct ncbigene:5894
CSK GeneProduct ncbigene:1445
PIP5K2A GeneProduct ncbigene:5305
PIP5K2C GeneProduct ncbigene:79837
MAPK3 GeneProduct ncbigene:5595
PDGFB GeneProduct ncbigene:5155
CYFIP2 GeneProduct ncbigene:26999
MYL3 GeneProduct ncbigene:4634
ACTG1 GeneProduct ncbigene:71
MAP2K2 GeneProduct ncbigene:5605
ARHGEF6 GeneProduct ncbigene:9459
PXN GeneProduct ncbigene:5829
RAC2 GeneProduct ncbigene:5880
FGFR2 GeneProduct ncbigene:2263
PIK3CD GeneProduct ncbigene:5293
MAPK6 GeneProduct ncbigene:5597
PAK6 GeneProduct ncbigene:56924
Apc2 GeneProduct ncbigene:10297
GIT1 GeneProduct ncbigene:28964
CFL1 GeneProduct ncbigene:1072
MOS GeneProduct ncbigene:4342
FGF6 GeneProduct ncbigene:2251
FGF1 GeneProduct ncbigene:2246
F2 GeneProduct ncbigene:2147
F2R GeneProduct ncbigene:2149
FGFR1 GeneProduct ncbigene:2260
FGF11 GeneProduct ncbigene:2256
FGF8 GeneProduct ncbigene:2253
VAV1 GeneProduct ncbigene:7409
MAPK4 GeneProduct ncbigene:5596


  1. Cell adhesion and Rho small GTPases. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. J Cell Sci. 1999 Dec;112 ( Pt 24):4491–500. PubMed Europe PMC Scholia
  2. Rho GTPases: signaling, migration, and invasion. Schmitz AA, Govek EE, Böttner B, Van Aelst L. Exp Cell Res. 2000 Nov 25;261(1):1–12. PubMed Europe PMC Scholia
  3. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Sastry SK, Burridge K. Exp Cell Res. 2000 Nov 25;261(1):25–36. PubMed Europe PMC Scholia
  4. Small GTP-binding proteins. Takai Y, Sasaki T, Matozaki T. Physiol Rev. 2001 Jan;81(1):153–208. PubMed Europe PMC Scholia
  5. The cytoskeleton, cellular motility and the reductionist agenda. Pollard TD. Nature. 2003 Apr 17;422(6933):741–5. PubMed Europe PMC Scholia
  6. Cell migration: integrating signals from front to back. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, et al. Science. 2003 Dec 5;302(5651):1704–9. PubMed Europe PMC Scholia
  7. Rho and Rac take center stage. Burridge K, Wennerberg K. Cell. 2004 Jan 23;116(2):167–79. PubMed Europe PMC Scholia