Wnt signaling pathway and pluripotency (WP1010)

Bos taurus

This pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal. A central organizing theme of this pathway are known drug targets which promote self-renewal or pluripotency (BIO and IQ-1) and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It should be noted that it is unclear whether all the depicted components participate in this pathway in human embryonic stem cells. Interactions and object/gene groups for the pathway exist for the majority of components.

Authors

Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

Wnt signaling, canonical pathway Wnt signaling pathway

Cell Type Ontology

pluripotent stem cell

Participants

Label Type Compact URI Comment
IQ-1 Metabolite cas:331001-62-8
BIO Metabolite pubchem.compound:5287844
FZD8 GeneProduct ensembl:ENSBTAG00000015072 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8325
APC GeneProduct ensembl:ENSBTAG00000018852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
CTBP1 GeneProduct ensembl:ENSBTAG00000008480 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1487
MMP7 GeneProduct ensembl:ENSBTAG00000004594 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4316
DVL2 GeneProduct ensembl:ENSBTAG00000003075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1856
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
WNT3A GeneProduct ensembl:ENSBTAG00000039397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
FZD10 GeneProduct ensembl:ENSBTAG00000007047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111432
NFYA GeneProduct ensembl:ENSBTAG00000009905 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001167
PRKCI GeneProduct ensembl:ENSBTAG00000001403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
ESRRB GeneProduct ensembl:ENSBTAG00000012285 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2103
WNT10B GeneProduct ensembl:ENSBTAG00000015347 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7480
PLAU GeneProduct ensembl:ENSBTAG00000005947 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328
WNT2B GeneProduct ensembl:ENSBTAG00000014291 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7482
CREBBP GeneProduct ensembl:ENSBTAG00000026403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
PPP2CA GeneProduct ensembl:ENSBTAG00000000469 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5515
PPP2CB GeneProduct ensembl:ENSBTAG00000009245 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516
TCF7 GeneProduct ensembl:ENSBTAG00000001002 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081059
TCFL2 GeneProduct ensembl:ENSBTAG00000021574 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148737
PRKCA GeneProduct ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
LEF1 GeneProduct ensembl:ENSBTAG00000006844 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51176
SOX2 GeneProduct ensembl:ENSBTAG00000011598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6657
MGC155143 GeneProduct ensembl:ENSBTAG00000017184 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10009
RACGAP1 GeneProduct ensembl:ENSBTAG00000012784 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29127
MAPK10 GeneProduct ensembl:ENSBTAG00000020048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
FZD2 GeneProduct ensembl:ENSBTAG00000020590 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2535
WNT16 GeneProduct ensembl:ENSBTAG00000002940 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51384
WNT2 GeneProduct ensembl:ENSBTAG00000008097 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7472
WNT9B GeneProduct ensembl:ENSBTAG00000002664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7484
WNT5A GeneProduct ensembl:ENSBTAG00000020221 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
PPP2R1A GeneProduct ensembl:ENSBTAG00000019851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5518
TCF7L1 GeneProduct ensembl:ENSBTAG00000010111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83439
PPARD GeneProduct ensembl:ENSBTAG00000017542 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5467
EP300 GeneProduct ensembl:ENSBTAG00000016198 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
PRKCQ GeneProduct ensembl:ENSBTAG00000010664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5588
FBXW2 GeneProduct ensembl:ENSBTAG00000000712 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26190
NLK GeneProduct ensembl:ENSBTAG00000014825 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51701
PPM1J GeneProduct ensembl:ENSBTAG00000006081 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155367
WNT1 GeneProduct ensembl:ENSBTAG00000015364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7471
PRKCB GeneProduct ensembl:ENSBTAG00000020921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
PRKD1 GeneProduct ensembl:ENSBTAG00000012789 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5587
FOXD3 GeneProduct ensembl:ENSBTAG00000008501 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187140
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
WNT6 GeneProduct ensembl:ENSBTAG00000013990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7475
DVL1 GeneProduct ensembl:ENSBTAG00000010696 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1855
PAFAH1B1 GeneProduct ensembl:ENSBTAG00000016806 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5048
MAP2K4 GeneProduct ensembl:ENSBTAG00000012103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6416
WNT11 GeneProduct ensembl:ENSBTAG00000010820 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7481
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
CCND1 GeneProduct ensembl:ENSBTAG00000017514 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
WNT3 GeneProduct ensembl:ENSBTAG00000016012 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7473
PPP2R2B GeneProduct ensembl:ENSBTAG00000001862 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5521
MAPK9 GeneProduct ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
PPP2R3B GeneProduct ensembl:ENSBTAG00000046338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:28227
POU5F1 GeneProduct ensembl:ENSBTAG00000001873 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5460
WNT7A GeneProduct ensembl:ENSBTAG00000001668 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7476
CTBP2 GeneProduct ensembl:ENSBTAG00000003397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1488
PPP2R1B GeneProduct ensembl:ENSBTAG00000020277 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5519
PPP2R5E GeneProduct ensembl:ENSBTAG00000019784 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5529
PRKCZ GeneProduct ensembl:ENSBTAG00000014119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
LRP6 GeneProduct ensembl:ENSBTAG00000011761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4040
FZD4 GeneProduct ensembl:ENSBTAG00000040128 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8322
DVL3 GeneProduct ensembl:ENSBTAG00000019336 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1857
PRKCG GeneProduct ensembl:ENSBTAG00000013550 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5582
FOSL1 GeneProduct ensembl:ENSBTAG00000006194 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8061
AXIN2 GeneProduct ensembl:ENSBTAG00000030162 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8313
FZD9 GeneProduct ensembl:ENSBTAG00000020742 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8326
RHOA GeneProduct ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
FZD6 GeneProduct ensembl:ENSBTAG00000010529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8323
NKD1 GeneProduct ensembl:ENSBTAG00000012295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85407
FZD7 GeneProduct ensembl:ENSBTAG00000002283 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8324
NKD2 GeneProduct ensembl:ENSBTAG00000034435 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85409
FRAT1 GeneProduct ensembl:ENSBTAG00000007956 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10023
AXIN1 GeneProduct ensembl:ENSBTAG00000016577 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
NANOG GeneProduct ensembl:ENSBTAG00000020916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79923
PPP2R5C GeneProduct ensembl:ENSBTAG00000020192 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5527
GSK3B GeneProduct ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
WNT4 GeneProduct ensembl:ENSBTAG00000022671 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54361
PPP2R2A GeneProduct ensembl:ENSBTAG00000018317 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5520
CSNK1E GeneProduct ensembl:ENSBTAG00000047582 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1454
PPP2R2C GeneProduct ensembl:ENSBTAG00000020598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5522
FZD3 GeneProduct ensembl:ENSBTAG00000006621 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7976
CTNND1 GeneProduct ensembl:ENSBTAG00000002411 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1500
WNT10A GeneProduct ensembl:ENSBTAG00000009217 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80326
LDLR GeneProduct ensembl:ENSBTAG00000012314 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
MAP3K7 GeneProduct ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
WNT11 GeneProduct ensembl:ENSBTAG00000010820 Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. PMID: 15701629
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7481
PRKCE GeneProduct ensembl:ENSBTAG00000020614 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5581
FZD5 GeneProduct ensembl:ENSBTAG00000020957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7855
CCND3 GeneProduct ensembl:ENSBTAG00000010106 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
PPP2R3A GeneProduct ensembl:ENSBTAG00000023416 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5523
PRKCH GeneProduct ensembl:ENSBTAG00000003276 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5583
CD44 GeneProduct ensembl:ENSBTAG00000011578 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:960
WNT7B GeneProduct ensembl:ENSBTAG00000009532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7477
WNT5B GeneProduct ensembl:ENSBTAG00000001341 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81029
FZD1 GeneProduct ensembl:ENSBTAG00000002107 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8321
PRKCD GeneProduct ensembl:ENSBTAG00000008719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
PPP2R4 GeneProduct ensembl:ENSBTAG00000001933 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5524
LRP5 GeneProduct ensembl:ENSBTAG00000005903 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4041
CCND2 GeneProduct ensembl:ENSBTAG00000016649 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
LRRK2 GeneProduct ensembl:ENSBTAG00000016260 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:120892

References

  1. Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Sato N, Brivanlou AH. Methods Mol Biol. 2006;331:115–28. PubMed Europe PMC Scholia
  2. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia
  3. Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal. Yi F, Pereira L, Merrill BJ. Stem Cells. 2008 Aug;26(8):1951–60. PubMed Europe PMC Scholia
  4. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. Zhang X, Zhang J, Wang T, Esteban MA, Pei D. J Biol Chem. 2008 Dec 19;283(51):35825–33. PubMed Europe PMC Scholia
  5. (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, et al. Cell Death Differ. 2012 Oct;19(10):1623–33. PubMed Europe PMC Scholia